KEGG   ORTHOLOGY: K21934
Entry
K21934            Tight     KO                                     

Name
frbC
Definition
2-phosphonomethylmalate synthase [EC:2.3.3.19]
Pathway
ko00440  Phosphonate and phosphinate metabolism
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00440 Phosphonate and phosphinate metabolism
    K21934  frbC; 2-phosphonomethylmalate synthase
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.3  Acyl groups converted into alkyl groups on transfer
    2.3.3.19  2-phosphonomethylmalate synthase
     K21934  frbC; 2-phosphonomethylmalate synthase
Other DBs
RN: R11708
COG: COG0119
Genes
AG: ABB90392(frbC)
Reference
  Authors
Eliot AC, Griffin BM, Thomas PM, Johannes TW, Kelleher NL, Zhao H, Metcalf WW
  Title
Cloning, expression, and biochemical characterization of Streptomyces rubellomurinus genes required for biosynthesis of antimalarial compound FR900098.
  Journal
Chem Biol 15:765-70 (2008)
DOI:10.1016/j.chembiol.2008.07.010
  Sequence

KEGG   ENZYME: 2.3.3.19
Entry
EC 2.3.3.19                 Enzyme                                 

Name
2-phosphonomethylmalate synthase;
2-phosphinomethylmalic acid synthase;
PMM synthase
Class
Transferases;
Acyltransferases;
Acyl groups converted into alkyl groups on transfer
Sysname
acetyl-CoA:3-phosphonopyruvate C-acetyltransferase
Reaction(IUBMB)
acetyl-CoA + H2O + 3-phosphonopyruvate = (R)-2-(phosphonomethyl)malate + CoA [RN:R11708]
Reaction(KEGG)
R11708
Substrate
acetyl-CoA [CPD:C00024];
H2O [CPD:C00001];
3-phosphonopyruvate [CPD:C02798]
Product
(R)-2-(phosphonomethyl)malate [CPD:C21613];
CoA [CPD:C00010]
Comment
The enzyme, isolated from several Streptomyces species, participate in the biosynthesis of certain phosphonate antibiotics. The enzyme is analogous to EC 2.3.3.1 (Si)-citrate synthase.
History
EC 2.3.3.19 created 2017
Pathway
ec00440  Phosphonate and phosphinate metabolism
Orthology
K21934  2-phosphonomethylmalate synthase
Reference
1  [PMID:3781934]
  Authors
Shimotohno K, Seto H, Otake N, Imai S, Satoh A
  Title
Studies on the biosynthesis of bialaphos (SE-1293). 7. The absolute configuration of 2-phosphinomethylmalic acid, a biosynthetic intermediate of bialaphos.
  Journal
J Antibiot (Tokyo) 39:1356-9 (1986)
DOI:10.7164/antibiotics.39.1356
Reference
2  [PMID:3170341]
  Authors
Shimotohno KW, Seto H, Otake N, Imai S, Murakami T
  Title
Studies on the biosynthesis of bialaphos (SF-1293). 8. Purification and characterization of 2-phosphinomethylmalic acid synthase from Streptomyces hygroscopicus SF-1293.
  Journal
J Antibiot (Tokyo) 41:1057-65 (1988)
DOI:10.7164/antibiotics.41.1057
Reference
3  [PMID:18721747]
  Authors
Eliot AC, Griffin BM, Thomas PM, Johannes TW, Kelleher NL, Zhao H, Metcalf WW
  Title
Cloning, expression, and biochemical characterization of Streptomyces rubellomurinus genes required for biosynthesis of antimalarial compound FR900098.
  Journal
Chem Biol 15:765-70 (2008)
DOI:10.1016/j.chembiol.2008.07.010
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.3.3.19
IUBMB Enzyme Nomenclature: 2.3.3.19
ExPASy - ENZYME nomenclature database: 2.3.3.19
BRENDA, the Enzyme Database: 2.3.3.19

KEGG   REACTION: R11708
Entry
R11708                      Reaction                               

Name
acetyl-CoA:3-phosphonopyruvate C-acetyltransferase
Definition
Acetyl-CoA + H2O + 3-Phosphonopyruvate <=> (R)-2-(Phosphonomethyl)malate + CoA
Equation
Reaction class
RC00004  C00010_C00024
RC00067  C02798_C21613
Enzyme
Pathway
rn00440  Phosphonate and phosphinate metabolism
Orthology
K21934  2-phosphonomethylmalate synthase [EC:2.3.3.19]
Other DBs
RHEA: 52147

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