KEGG   ORTHOLOGY: K21949
Entry
K21949                      KO                                     

Name
sbnA
Definition
N-(2-amino-2-carboxyethyl)-L-glutamate synthase [EC:2.5.1.140]
Pathway
ko00997  Biosynthesis of various secondary metabolites - part 3
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Module
M00875  Staphyloferrin B biosynthesis, L-serine => staphyloferrin B
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00997 Biosynthesis of various secondary metabolites - part 3
    K21949  sbnA; N-(2-amino-2-carboxyethyl)-L-glutamate synthase
Enzymes [BR:ko01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.140  N-(2-amino-2-carboxyethyl)-L-glutamate synthase
     K21949  sbnA; N-(2-amino-2-carboxyethyl)-L-glutamate synthase
Other DBs
RN: R11705
COG: COG0031
Genes
SPE: Spro_0339
SPLY: Q5A_016930(sbnA_2)
SERA: Ser39006_012170
SERQ: CWC46_12165
DDA: Dd703_1672
CED: LH89_16305
DFN: CVE23_18620
PVA: Pvag_pPag20157(cbs)
XBV: XBW1_4006
XPO: XPG1_1970
XOR: XOC_2071
PSB: Psyr_2745
PSYR: N018_13505
PEN: PSEEN2152
PSES: PSCI_4171
ACC: BDGL_001497(cysM)
AGU: AS4_16170
SDN: Sden_0590
SPSW: Sps_04805
CEK: D0B88_14045(sbnA)
CEG: D0C16_05375(sbnA)
LLO: LLO_2375
PSE: NH8B_2511
DEE: HQN60_15880(sbnA)
RSO: RSp0417
RSL: RPSI07_mp0378(cysM)
RSN: RSPO_m01411(cysM)
RSM: CMR15_mp10430(cysM)
RSE: F504_3907
RSY: RSUY_34850(sbnA)
CNC: CNE_2c14830(sbnA1)
RME: Rmet_1117(cysK)
BGU: KS03_3144
BGO: BM43_2792
PPNO: DA70_13860
PPUL: RO07_10960
PSPU: NA29_06785
PAPI: SG18_11365
PFIB: PI93_002405(sbnA)
VEI: Veis_1207
JAG: GJA_5089
SCL: sce2389(cysK1)
CCRO: CMC5_048460(cysM)
MNO: Mnod_6948
MAQU: Maq22A_c25425(cysK)
PPIC: PhaeoP14_00142(cysK_1)
HNE: HNE_1409
TMO: TMO_2351(cysM)
BTHI: BTK_29564
BJS: MY9_0678
SAU: SA0112(sbnA)
SAV: SAV0116
SAW: SAHV_0115
SAM: MW0089(sbnA)
SAS: SAS0090
SAR: SAR0119
SAC: SACOL0100
SAE: NWMN_0060(sbnA)
SAD: SAAV_0084
SUU: M013TW_0106(sbnA)
SUE: SAOV_0063
SUC: ECTR2_72
SUZ: MS7_0108
SUX: SAEMRSA15_00820(sbnA)
SUW: SATW20_01280(sbnA)
SUG: SAPIG0127
SUF: SARLGA251_00910(sbnA)
SAUA: SAAG_00600
SAUS: SA40_0083(sbnA)
SAUU: SA957_0098(sbnA)
SAUG: SA268_0095(sbnA)
SAUZ: SAZ172_0127(sbnA)
SAUV: SAI7S6_1000720(sbnA)
SAUW: SAI5S5_1000720(sbnA)
SAUX: SAI6T6_1000720(sbnA)
SAUY: SAI8T7_1000720(sbnA)
SAUF: X998_0095
SAB: SAB0055
SUY: SA2981_0117(sbnA)
SAUB: C248_0104
SAUM: BN843_1180
SAUC: CA347_127
SAUR: SABB_01724(sbnA)
SAUI: AZ30_00605
SAUD: CH52_05140
SAMS: NI36_00500
SDT: SPSE_2124(sbnA)
SHU: SHYC_00355(sbnA)
SSCH: LH95_00355
SSCZ: RN70_00575
SAGQ: EP23_09770(sbnA)
SFF: FOB90_07435(sbnA)
SDP: NCTC12225_02341(sbnA)
BLR: BRLA_c008310(sbnA_2) BRLA_c026530(sbnA_1)
BRW: GOP56_05785(sbnA) GOP56_19905(sbnA)
PLV: ERIC2_c18210(sbnA)
PRI: PRIO_2663
PSWU: SY83_09670
PLEN: EIM92_22895(sbnA)
COH: EAV92_22105(sbnA)
SACA: FFV09_03660(sbnA)
KPUL: GXN76_14225(sbnA)
ASD: AS9A_4165
CGL: NCgl2055(Cgl2136)
CGB: cg2344
CGU: WA5_2055
CGT: cgR_2018
CGM: cgp_2344
CEF: CE1418
CAR: cauri_0358(cysM)
CRD: CRES_0051(cysM)
CSX: CSING_02080(cysM)
CGV: CGLAU_05755(sbnA)
CPEG: CPELA_03225(sbnA)
RHB: NY08_3270
TPR: Tpau_4292
SMA: SAVERM_3648(cysK2) SAVERM_7162(cysK3)
SCT: SCAT_2691(cysK)
SFA: Sfla_0079
SBH: SBI_01118(cysM1) SBI_06058 SBI_06801(cysM4)
SVE: SVEN_6263
SALS: SLNWT_4344
STRP: F750_6947
STRE: GZL_07298
SLD: T261_1317
SPRI: SPRI_5661
SRW: TUE45_01474(sbnA_3) TUE45_03040(sbnA_4) TUE45_06411(sbnA_5) TUE45_06592(sbnA_6)
SRN: A4G23_04389(sbnA_2)
SMAL: SMALA_8107
SLAU: SLA_7468
SALJ: SMD11_6085(cysK)
SLX: SLAV_10455(sbnA2)
SRJ: SRO_6287
SGD: ELQ87_17540(sbnA) ELQ87_36090(sbnA)
RTE: GSU10_11145(sbnA)
ARM: ART_0389
GLU: F0M17_15230(sbnA)
KRS: EQG70_12300(sbnA)
JDE: Jden_2538
PAC: PPA1290
PAW: PAZ_c13510(sbnA)
PACC: PAC1_06770
PFRE: RM25_2296
PACD: EGX94_06790(sbnA)
KQI: F1D05_30880(sbnA)
MGG: MPLG2_2677(sbnA)
TCU: Tcur_1884
NML: Namu_3877
GOB: Gobs_3071
SEN: SACE_3013(cysK3) SACE_4282(cysK3)
SACE: GIY23_00875(sbnA) GIY23_12340(sbnA) GIY23_12450(sbnA)
SACG: FDZ84_26430(sbnA)
AMD: AMED_4033(cysK) AMED_4039(cysK) AMED_4795(cysK) AMED_6227(cysK)
AMM: AMES_3985(cysK) AMES_3991(cysK) AMES_4736(cysK) AMES_6137(cysK)
AMZ: B737_3985(cysK) B737_3991(cysK) B737_4736(cysK) B737_6137(cysK)
AOI: AORI_4007(cysK)
AMYY: YIM_22875(sbnA2) YIM_25710(sbnA3) YIM_32325(sbnA4)
AORI: SD37_26475
PSEH: XF36_12295
SESP: BN6_32460
KAL: KALB_6147
ACTI: UA75_17685
ACAD: UA74_17145
SAQ: Sare_0366
MTEM: GCE86_08140(sbnA)
ACTN: L083_2990
HAU: Haur_1863
RBA: RB4386
RUL: UC8_29740(sbnA)
MFF: MFFC18_37640(sbnA)
FMR: Fuma_06210(sbnA)
GMR: GmarT_03580(sbnA_1) GmarT_19280(sbnA_2)
ACA: ACP_1153
FLN: FLA_1937
MARM: YQ22_01610
KOS: KORDIASMS9_04688(sbnA)
EMAR: D1013_08800(sbnA)
 » show all
Reference
  Authors
Kobylarz MJ, Grigg JC, Takayama SJ, Rai DK, Heinrichs DE, Murphy ME
  Title
Synthesis of L-2,3-diaminopropionic acid, a siderophore and antibiotic precursor.
  Journal
Chem Biol 21:379-88 (2014)
DOI:10.1016/j.chembiol.2013.12.011

KEGG   ENZYME: 2.5.1.140
Entry
EC 2.5.1.140                Enzyme                                 

Name
N-(2-amino-2-carboxyethyl)-L-glutamate synthase;
SbnA;
ACEGA synthase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
Sysname
O-phospho-L-serine:L-glutamate N-(2S)-2-amino-2-carboxyethyltransferase
Reaction(IUBMB)
O-phospho-L-serine + L-glutamate = N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate + phosphate [RN:R11705]
Reaction(KEGG)
R11705
Substrate
O-phospho-L-serine [CPD:C01005];
L-glutamate [CPD:C00025]
Product
N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate [CPD:C21559];
phosphate [CPD:C00009]
Comment
The enzyme, characterized from the bacterium Staphylococcus aureus, is involved in the biosynthesis of the siderophore staphyloferrin B.
History
EC 2.5.1.140 created 2017
Pathway
ec00997  Biosynthesis of various secondary metabolites - part 3
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K21949  N-(2-amino-2-carboxyethyl)-L-glutamate synthase
Genes
SPE: Spro_0339
SPLY: Q5A_016930(sbnA_2)
SERA: Ser39006_012170
SERQ: CWC46_12165
DDA: Dd703_1672
CED: LH89_16305
DFN: CVE23_18620
PVA: Pvag_pPag20157(cbs)
XBV: XBW1_4006
XPO: XPG1_1970
XOR: XOC_2071
PSB: Psyr_2745
PSYR: N018_13505
PEN: PSEEN2152
PSES: PSCI_4171
ACC: BDGL_001497(cysM)
AGU: AS4_16170
SDN: Sden_0590
SPSW: Sps_04805
CEK: D0B88_14045(sbnA)
CEG: D0C16_05375(sbnA)
LLO: LLO_2375
PSE: NH8B_2511
DEE: HQN60_15880(sbnA)
RSO: RSp0417
RSL: RPSI07_mp0378(cysM)
RSN: RSPO_m01411(cysM)
RSM: CMR15_mp10430(cysM)
RSE: F504_3907
RSY: RSUY_34850(sbnA)
CNC: CNE_2c14830(sbnA1)
RME: Rmet_1117(cysK)
BGU: KS03_3144
BGO: BM43_2792
PPNO: DA70_13860
PPUL: RO07_10960
PSPU: NA29_06785
PAPI: SG18_11365
PFIB: PI93_002405(sbnA)
VEI: Veis_1207
JAG: GJA_5089
SCL: sce2389(cysK1)
CCRO: CMC5_048460(cysM)
MNO: Mnod_6948
MAQU: Maq22A_c25425(cysK)
PPIC: PhaeoP14_00142(cysK_1)
HNE: HNE_1409
TMO: TMO_2351(cysM)
BTHI: BTK_29564
BJS: MY9_0678
SAU: SA0112(sbnA)
SAV: SAV0116
SAW: SAHV_0115
SAM: MW0089(sbnA)
SAS: SAS0090
SAR: SAR0119
SAC: SACOL0100
SAE: NWMN_0060(sbnA)
SAD: SAAV_0084
SUU: M013TW_0106(sbnA)
SUE: SAOV_0063
SUC: ECTR2_72
SUZ: MS7_0108
SUX: SAEMRSA15_00820(sbnA)
SUW: SATW20_01280(sbnA)
SUG: SAPIG0127
SUF: SARLGA251_00910(sbnA)
SAUA: SAAG_00600
SAUS: SA40_0083(sbnA)
SAUU: SA957_0098(sbnA)
SAUG: SA268_0095(sbnA)
SAUZ: SAZ172_0127(sbnA)
SAUV: SAI7S6_1000720(sbnA)
SAUW: SAI5S5_1000720(sbnA)
SAUX: SAI6T6_1000720(sbnA)
SAUY: SAI8T7_1000720(sbnA)
SAUF: X998_0095
SAB: SAB0055
SUY: SA2981_0117(sbnA)
SAUB: C248_0104
SAUM: BN843_1180
SAUC: CA347_127
SAUR: SABB_01724(sbnA)
SAUI: AZ30_00605
SAUD: CH52_05140
SAMS: NI36_00500
SDT: SPSE_2124(sbnA)
SHU: SHYC_00355(sbnA)
SSCH: LH95_00355
SSCZ: RN70_00575
SAGQ: EP23_09770(sbnA)
SFF: FOB90_07435(sbnA)
SDP: NCTC12225_02341(sbnA)
BLR: BRLA_c008310(sbnA_2) BRLA_c026530(sbnA_1)
BRW: GOP56_05785(sbnA) GOP56_19905(sbnA)
PLV: ERIC2_c18210(sbnA)
PRI: PRIO_2663
PSWU: SY83_09670
PLEN: EIM92_22895(sbnA)
COH: EAV92_22105(sbnA)
SACA: FFV09_03660(sbnA)
KPUL: GXN76_14225(sbnA)
ASD: AS9A_4165
CGL: NCgl2055(Cgl2136)
CGB: cg2344
CGU: WA5_2055
CGT: cgR_2018
CGM: cgp_2344
CEF: CE1418
CAR: cauri_0358(cysM)
CRD: CRES_0051(cysM)
CSX: CSING_02080(cysM)
CGV: CGLAU_05755(sbnA)
CPEG: CPELA_03225(sbnA)
RHB: NY08_3270
TPR: Tpau_4292
SMA: SAVERM_3648(cysK2) SAVERM_7162(cysK3)
SCT: SCAT_2691(cysK)
SFA: Sfla_0079
SBH: SBI_01118(cysM1) SBI_06058 SBI_06801(cysM4)
SVE: SVEN_6263
SALS: SLNWT_4344
STRP: F750_6947
STRE: GZL_07298
SLD: T261_1317
SPRI: SPRI_5661
SRW: TUE45_01474(sbnA_3) TUE45_03040(sbnA_4) TUE45_06411(sbnA_5) TUE45_06592(sbnA_6)
SRN: A4G23_04389(sbnA_2)
SMAL: SMALA_8107
SLAU: SLA_7468
SALJ: SMD11_6085(cysK)
SLX: SLAV_10455(sbnA2)
SRJ: SRO_6287
SGD: ELQ87_17540(sbnA) ELQ87_36090(sbnA)
RTE: GSU10_11145(sbnA)
ARM: ART_0389
GLU: F0M17_15230(sbnA)
KRS: EQG70_12300(sbnA)
JDE: Jden_2538
PAC: PPA1290
PAW: PAZ_c13510(sbnA)
PACC: PAC1_06770
PFRE: RM25_2296
PACD: EGX94_06790(sbnA)
KQI: F1D05_30880(sbnA)
MGG: MPLG2_2677(sbnA)
TCU: Tcur_1884
NML: Namu_3877
GOB: Gobs_3071
SEN: SACE_3013(cysK3) SACE_4282(cysK3)
SACE: GIY23_00875(sbnA) GIY23_12340(sbnA) GIY23_12450(sbnA)
SACG: FDZ84_26430(sbnA)
AMD: AMED_4033(cysK) AMED_4039(cysK) AMED_4795(cysK) AMED_6227(cysK)
AMM: AMES_3985(cysK) AMES_3991(cysK) AMES_4736(cysK) AMES_6137(cysK)
AMZ: B737_3985(cysK) B737_3991(cysK) B737_4736(cysK) B737_6137(cysK)
AOI: AORI_4007(cysK)
AMYY: YIM_22875(sbnA2) YIM_25710(sbnA3) YIM_32325(sbnA4)
AORI: SD37_26475
PSEH: XF36_12295
SESP: BN6_32460
KAL: KALB_6147
ACTI: UA75_17685
ACAD: UA74_17145
SAQ: Sare_0366
MTEM: GCE86_08140(sbnA)
ACTN: L083_2990
HAU: Haur_1863
RBA: RB4386
RUL: UC8_29740(sbnA)
MFF: MFFC18_37640(sbnA)
FMR: Fuma_06210(sbnA)
GMR: GmarT_03580(sbnA_1) GmarT_19280(sbnA_2)
ACA: ACP_1153
FLN: FLA_1937
MARM: YQ22_01610
KOS: KORDIASMS9_04688(sbnA)
EMAR: D1013_08800(sbnA)
 » show all
Reference
1  [PMID:21906287]
  Authors
Beasley FC, Cheung J, Heinrichs DE
  Title
Mutation of L-2,3-diaminopropionic acid synthase genes blocks staphyloferrin B synthesis in Staphylococcus aureus.
  Journal
BMC Microbiol 11:199 (2011)
DOI:10.1186/1471-2180-11-199
Reference
2  [PMID:24485762]
  Authors
Kobylarz MJ, Grigg JC, Takayama SJ, Rai DK, Heinrichs DE, Murphy ME
  Title
Synthesis of L-2,3-diaminopropionic acid, a siderophore and antibiotic precursor.
  Journal
Chem Biol 21:379-88 (2014)
DOI:10.1016/j.chembiol.2013.12.011
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.140
IUBMB Enzyme Nomenclature: 2.5.1.140
ExPASy - ENZYME nomenclature database: 2.5.1.140
BRENDA, the Enzyme Database: 2.5.1.140

KEGG   REACTION: R11705
Entry
R11705                      Reaction                               

Name
O-phospho-L-serine:L-glutamate N-(2S)-2-amino-2-carboxyethyltransferase
Definition
O-Phospho-L-serine + L-Glutamate <=> N-[(2S)-2-Amino-2-carboxyethyl]-L-glutamate + Orthophosphate
Equation
Reaction class
RC00215  C00025_C21559
Enzyme
Pathway
rn00997  Biosynthesis of various secondary metabolites - part 3
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00875  Staphyloferrin B biosynthesis, L-serine => staphyloferrin B
Orthology
K21949  N-(2-amino-2-carboxyethyl)-L-glutamate synthase [EC:2.5.1.140]
Other DBs
RHEA: 52387

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