KEGG   ORTHOLOGY: K22480
Entry
K22480                      KO                                     

Name
hdrA1
Definition
heterodisulfide reductase subunit A1 [EC:1.8.7.3]
Pathway
ko00680  Methane metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01200  Carbon metabolism
Module
M00356  Methanogenesis, methanol => methane
M00357  Methanogenesis, acetate => methane
M00563  Methanogenesis, methylamine/dimethylamine/trimethylamine => methane
M00567  Methanogenesis, CO2 => methane
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00680 Methane metabolism
    K22480  hdrA1; heterodisulfide reductase subunit A1
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.8  Acting on a sulfur group of donors
   1.8.7  With an iron-sulfur protein as acceptor
    1.8.7.3  ferredoxin:CoB-CoM heterodisulfide reductase
     K22480  hdrA1; heterodisulfide reductase subunit A1
Other DBs
RN: R11931
COG: COG1148
Genes
DTO: TOL2_C11620(hdlA3)
MST: Msp_0127(hdrA2)
METB: AW729_06500
MSI: Msm_0082
MEB: Abm4_0695(hdrA1)
MMIL: sm9_0984(hdrA1)
MEYE: TL18_05450
MOL: YLM1_0874
MEL: Metbo_1205 Metbo_2477
MEW: MSWAN_0048 MSWAN_1005
METH: MBMB1_1157
MFC: BRM9_1364(hdrA1)
MCUB: MCBB_1057(hdrA1)
MBAR: MSBR2_1663
MBAK: MSBR3_1666
MAC: MA_3128(hdrA)
MMA: MM_0387
MMAC: MSMAC_0918
METM: MSMTP_2284
MTHR: MSTHT_2519
MTHE: MSTHC_0766
MHOR: MSHOH_1117
MMH: Mmah_0415
MPD: MCP_1989(hdrA_mvhD)
MEZ: Mtc_1471(hdrA1)
RCI: LRC437(hdrA-1)
 » show all
Reference
  Authors
Buan NR, Metcalf WW
  Title
Methanogenesis by Methanosarcina acetivorans involves two structurally and functionally distinct classes of heterodisulfide reductase.
  Journal
Mol Microbiol 75:843-53 (2010)
DOI:10.1111/j.1365-2958.2009.06990.x
  Sequence
[mac:MA_3128]

KEGG   ORTHOLOGY: K22481
Entry
K22481                      KO                                     

Name
hdrB1
Definition
heterodisulfide reductase subunit B1 [EC:1.8.7.3]
Pathway
ko00680  Methane metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01200  Carbon metabolism
Module
M00356  Methanogenesis, methanol => methane
M00357  Methanogenesis, acetate => methane
M00563  Methanogenesis, methylamine/dimethylamine/trimethylamine => methane
M00567  Methanogenesis, CO2 => methane
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00680 Methane metabolism
    K22481  hdrB1; heterodisulfide reductase subunit B1
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.8  Acting on a sulfur group of donors
   1.8.7  With an iron-sulfur protein as acceptor
    1.8.7.3  ferredoxin:CoB-CoM heterodisulfide reductase
     K22481  hdrB1; heterodisulfide reductase subunit B1
Other DBs
RN: R11931
COG: COG2048
Genes
BTS: Btus_2497
KYR: CVV65_12495
SAY: TPY_3530
SAP: Sulac_1385
STHR: BXT84_06255
AFO: Afer_0965
SYL: AWQ21_15430
CAN: Cyan10605_2791
CYC: PCC7424_1698
OAC: Oscil6304_5896
TRO: trd_0154
CTS: Ctha_0137
MST: Msp_0126(hdrB2)
MSI: Msm_0083
MEB: Abm4_0694(hdrB1)
MMIL: sm9_0983(hdrB1)
MEYE: TL18_05455
MOL: YLM1_0875
METH: MBMB1_1152
MFC: BRM9_1363(hdrB3)
MCUB: MCBB_1056(hdrB1)
MBAR: MSBR2_1665
MBAK: MSBR3_1668
MAC: MA_3126(hdrB)
MMA: MM_0389
MMAC: MSMAC_0916
METM: MSMTP_2282
MTHR: MSTHT_2521
MTHE: MSTHC_0764
MHOR: MSHOH_1119
MMH: Mmah_0417
MPD: MCP_1990(hdrB-2)
MEZ: Mtc_1470(hdrB-1)
RCI: LRC438(hdrB-1)
 » show all
Reference
  Authors
Buan NR, Metcalf WW
  Title
Methanogenesis by Methanosarcina acetivorans involves two structurally and functionally distinct classes of heterodisulfide reductase.
  Journal
Mol Microbiol 75:843-53 (2010)
DOI:10.1111/j.1365-2958.2009.06990.x
  Sequence
[mac:MA_3126]

KEGG   ORTHOLOGY: K22482
Entry
K22482                      KO                                     

Name
hdrC1
Definition
heterodisulfide reductase subunit C1 [EC:1.8.7.3]
Pathway
ko00680  Methane metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01200  Carbon metabolism
Module
M00356  Methanogenesis, methanol => methane
M00357  Methanogenesis, acetate => methane
M00563  Methanogenesis, methylamine/dimethylamine/trimethylamine => methane
M00567  Methanogenesis, CO2 => methane
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00680 Methane metabolism
    K22482  hdrC1; heterodisulfide reductase subunit C1
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.8  Acting on a sulfur group of donors
   1.8.7  With an iron-sulfur protein as acceptor
    1.8.7.3  ferredoxin:CoB-CoM heterodisulfide reductase
     K22482  hdrC1; heterodisulfide reductase subunit C1
Other DBs
RN: R11931
COG: COG1150
Genes
HHC: M911_11240
EBS: ECTOBSL9_0287
TGR: Tgr7_2216
TKM: TK90_0632
TNI: TVNIR_3249
TVR: TVD_10650
APRS: BI364_13815
ACII: C4901_12980
SULF: CAP31_01840
SPLB: SFPGR_29470
HDN: Hden_0689
RHC: RGUI_1283
AFR: AFE_2555
ACU: Atc_2352
BTS: Btus_2498
SLP: Slip_1202
SAY: TPY_3531
AFO: Afer_0964
TRO: trd_0155
AFD: Alfi_2099
ASH: AL1_26650
CTS: Ctha_0138
MST: Msp_0125(hdrC2)
MSI: Msm_0084
MEB: Abm4_0693(hdrC1)
MMIL: sm9_0982(hdrC1)
MEYE: TL18_05460
MOL: YLM1_0876
METH: MBMB1_1151
MFC: BRM9_1362(hdrC2)
MCUB: MCBB_1055(hdrC1)
MBAR: MSBR2_1664
MBAK: MSBR3_1667
MAC: MA_3127(hdrC)
MMA: MM_0388
MMAC: MSMAC_0917
METM: MSMTP_2283
MTHR: MSTHT_2520
MTHE: MSTHC_0765
MHOR: MSHOH_1118
MMH: Mmah_0416
MPD: MCP_1991(hdrC-2)
MEZ: Mtc_1469(hdrC-1)
RCI: LRC439(hdrC-1)
 » show all
Reference
  Authors
Buan NR, Metcalf WW
  Title
Methanogenesis by Methanosarcina acetivorans involves two structurally and functionally distinct classes of heterodisulfide reductase.
  Journal
Mol Microbiol 75:843-53 (2010)
DOI:10.1111/j.1365-2958.2009.06990.x
  Sequence
[mac:MA_3127]

KEGG   ORTHOLOGY: K03388
Entry
K03388                      KO                                     

Name
hdrA2
Definition
heterodisulfide reductase subunit A2 [EC:1.8.7.3 1.8.98.4 1.8.98.5 1.8.98.6]
Pathway
ko00680  Methane metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01200  Carbon metabolism
Module
M00356  Methanogenesis, methanol => methane
M00357  Methanogenesis, acetate => methane
M00563  Methanogenesis, methylamine/dimethylamine/trimethylamine => methane
M00567  Methanogenesis, CO2 => methane
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00680 Methane metabolism
    K03388  hdrA2; heterodisulfide reductase subunit A2
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.8  Acting on a sulfur group of donors
   1.8.7  With an iron-sulfur protein as acceptor
    1.8.7.3  ferredoxin:CoB-CoM heterodisulfide reductase
     K03388  hdrA2; heterodisulfide reductase subunit A2
   1.8.98  With other, known, physiological acceptors
    1.8.98.4  coenzyme F420:CoB-CoM heterodisulfide,ferredoxin reductase
     K03388  hdrA2; heterodisulfide reductase subunit A2
    1.8.98.5  H2:CoB-CoM heterodisulfide,ferredoxin reductase
     K03388  hdrA2; heterodisulfide reductase subunit A2
    1.8.98.6  formate:CoB-CoM heterodisulfide,ferredoxin reductase
     K03388  hdrA2; heterodisulfide reductase subunit A2
Other DBs
RN: R11928 R11931 R11943 R11944
COG: COG1148
Genes
TMB: Thimo_0253
HHC: M911_11230
EBS: ECTOBSL9_0285
TGR: Tgr7_2214
TKM: TK90_0634
TNI: TVNIR_3247(hdrA_[H])
TVR: TVD_10640
APRS: BI364_13805
ACII: C4901_12970
CBX: Cenrod_2147(hdrA)
SPLB: SFPGR_29450(hdrA)
SNIV: SFSGTM_27290(hdrA)
SLAC: SKTS_06230(hdrA-2)
GSU: GSU0090(hdrA)
GSK: KN400_0065(hdrA)
GME: Gmet_2084(bamE) Gmet_3426(hdrA)
GLO: Glov_0864
GBM: Gbem_0030(hdrA) Gbem_1447(bamE)
GEO: Geob_0215(bamE-1) Geob_0231(bamE-2) Geob_3723(hdrA)
DVU: DVU2402(hdrA)
DVL: Dvul_0828
DVM: DvMF_0324
DDS: Ddes_2100
DMA: DMR_01920(hdrA) DMR_22120
DGG: DGI_1050(hdrA)
DTR: RSDT_0567(hdrA)
DHY: DESAM_21330(hdrA)
DPI: BN4_11860(hdrA)
DPS: DP1010
DOL: Dole_1159
DML: Dmul_02770(hdrA1) Dmul_24500(bamE) Dmul_28860(hdrA2)
DAT: HRM2_06460 HRM2_11710(hdrA1) HRM2_11850(hdrA2) HRM2_14330(hdrA3) HRM2_14340(hdrA3') HRM2_22750(hdrA4)
DTO: TOL2_C03750(bamE1) TOL2_C11590(hdlA2) TOL2_C11630(hdlA3?) TOL2_C17900(hdlA5) TOL2_C24180(hdlA6) TOL2_C25730(hdlA7) TOL2_C28760(hdlA8) TOL2_C28830(hdlA9) TOL2_C41400(bamE2) TOL2_C43540(bamE3)
ADE: Adeh_4164
HDN: Hden_0691
BLAG: BLTE_14930(hdrA-2)
RHC: RGUI_1281
AFR: AFE_2553
ATX: GCD22_03148(hdrA) GCD22_03279(hdrA)
BTS: Btus_2496
RCH: RUM_10980
BPRO: PMF13cell1_01672(ndhI_2)
SWO: Swol_0397
SALQ: SYNTR_0264
PTH: PTH_1410(HdrA)
SGY: Sgly_1900
HMO: HM1_2008(hdrA)
SAY: TPY_3529(hdrA)
MTA: Moth_1453
MTHZ: MOTHA_c08510(ndhI3) MOTHA_c15280(mnmC2)
STED: SPTER_13760(mnmC)
AFO: Afer_0966
DFO: Dform_00920(hdrA) Dform_00941(hdrA)
TRO: trd_0153
OTE: Oter_3677
APS: CFPG_240
AFD: Alfi_2101
ASH: AL1_26630
BACC: BRDCF_p1060 BRDCF_p823(hdrA) BRDCF_p824(hdrA2)
CTE: CT1246(hdrA-2)
CPC: Cpar_0949
CCH: Cag_1029
CLI: Clim_1200
PVI: Cvib_0843
PLT: Plut_1109
PPH: Ppha_1306
CTS: Ctha_0136
AAE: aq_395(hdrA)
HTH: HTH_1881(hdrA)
TAL: Thal_1346
CABY: Cabys_1917
CTHI: THC_1756
BANA: BARAN1_0338(hdrA)
MMP: MMP0825(hdrA) MMP1697(hdrA)
MMD: GYY_04785
MMAK: MMKA1_09100(hdrA) MMKA1_19310(hdrA)
MMAO: MMOS7_08880(hdrA) MMOS7_18120(hdrA)
MMAD: MMJJ_01720(hdrA) MMJJ_11320(hdrA2)
MTH: MTH_1381
MMG: MTBMA_c17680(hdrA)
METC: MTCT_1255
MWO: MWSIV6_1762(hdrA)
METE: tca_01335(rsxB_2)
MST: Msp_1476(hdrA1)
MRU: mru_0117(hdrA)
MSI: Msm_1336
MEB: Abm4_1691(hdrA2)
MMIL: sm9_2251(hdrA2)
MEYE: TL18_00375
MOL: YLM1_1554
METH: MBMB1_1958(hdrA)
MFC: BRM9_2298(hdrA2)
MFI: DSM1535_1232(hdrA)
MCUB: MCBB_2243(hdrA3)
MFV: Mfer_0184
MKA: MK0249(hdrA_1) MK0265(hdrA_2)
MBAR: MSBR2_0910
MBAK: MSBR3_0798
MAC: MA_2868(hdrA)
MMA: MM_0056
METM: MSMTP_1469
MTHR: MSTHT_0375
MTHE: MSTHC_0346
MBU: Mbur_0552(hdrA)
MMET: MCMEM_1365
MMH: Mmah_0955
MTP: Mthe_1576
MCJ: MCON_3279(hdrA)
MHI: Mhar_0607
MBG: BN140_0752(hdrA1) BN140_1728(hdrA3)
MEMA: MMAB1_0971(hdrA) MMAB1_2223(hdrA)
MPD: MCP_1576(hdrA-1) MCP_2768(hdrA-2)
MEZ: Mtc_2473(hdrA-2)
RCI: RCIX596(hdrA-2) RRC258(hdrA-3)
HDF: AArcSl_1855(hdrA)
MEAR: Mpt1_c10580(hdrA)
MARC: AR505_1479
ABI: Aboo_0977
STO: STK_18730
SSO: SSO1131(hdrA)
SOL: Ssol_2101
SSOA: SULA_2132
SSOL: SULB_2133
SSOF: SULC_2131
SAI: Saci_0328(hdrA)
SID: M164_1089
SII: LD85_1217
SIH: SiH_1060
SIR: SiRe_0973
SIC: SiL_0979
MSE: Msed_1545
MCN: Mcup_0686
AHO: Ahos_1694
STEP: IC006_0777
BARC: AOA65_1112(hdrA_1) AOA65_1402(hdrA_3) AOA65_1719(hdlA_2) AOA65_1995(hdrA_4)
BARB: AOA66_0155(hdrA_1) AOA66_1510(hdrA_2) AOA66_1512(hdlA_2) AOA66_1513(hdrA_3) AOA66_1526(hdrA_4)
LOKI: Lokiarch_00290(hdrA_1) Lokiarch_01240(hdrA_2) Lokiarch_08680(hdrA_4) Lokiarch_09900(hdrA_5) Lokiarch_10040(hdlA_3) Lokiarch_17940(hdlA_5) Lokiarch_23600(hdrA_8) Lokiarch_25880(hdrA_9) Lokiarch_28050(hdrA_10) Lokiarch_40200(hdrA_13) Lokiarch_41160(hdrA_15) Lokiarch_49330(hdrA_16)
PSYT: DSAG12_01136(hdrA_1) DSAG12_01147(hdrA_2) DSAG12_02253(hdrA_3) DSAG12_02805(hdrA_4) DSAG12_03220(hdrA_5) DSAG12_03721(hdrA_6) DSAG12_03723(hdlA_4) DSAG12_03724(hdrA_7)
 » show all
Reference
PMID:2121478
  Authors
Hedderich R, Berkessel A, Thauer RK
  Title
Purification and properties of heterodisulfide reductase from Methanobacterium thermoautotrophicum (strain Marburg).
  Journal
Eur J Biochem 193:255-61 (1990)
DOI:10.1111/j.1432-1033.1990.tb19331.x
  Sequence
Reference
PMID:8119281
  Authors
Setzke E, Hedderich R, Heiden S, Thauer RK
  Title
H2: heterodisulfide oxidoreductase complex from Methanobacterium thermoautotrophicum. Composition and properties.
  Journal
Eur J Biochem 220:139-48 (1994)
DOI:10.1111/j.1432-1033.1994.tb18608.x
  Sequence
Reference
  Authors
Mander GJ, Pierik AJ, Huber H, Hedderich R
  Title
Two distinct heterodisulfide reductase-like enzymes in the sulfate-reducing archaeon Archaeoglobus profundus.
  Journal
Eur J Biochem 271:1106-16 (2004)
DOI:10.1111/j.1432-1033.2004.04013.x
  Sequence
[apo:Arcpr_1555] [afu:AF_1377]

KEGG   ORTHOLOGY: K03389
Entry
K03389                      KO                                     

Name
hdrB2
Definition
heterodisulfide reductase subunit B2 [EC:1.8.7.3 1.8.98.4 1.8.98.5 1.8.98.6]
Pathway
ko00680  Methane metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01200  Carbon metabolism
Module
M00356  Methanogenesis, methanol => methane
M00357  Methanogenesis, acetate => methane
M00563  Methanogenesis, methylamine/dimethylamine/trimethylamine => methane
M00567  Methanogenesis, CO2 => methane
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00680 Methane metabolism
    K03389  hdrB2; heterodisulfide reductase subunit B2
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.8  Acting on a sulfur group of donors
   1.8.7  With an iron-sulfur protein as acceptor
    1.8.7.3  ferredoxin:CoB-CoM heterodisulfide reductase
     K03389  hdrB2; heterodisulfide reductase subunit B2
   1.8.98  With other, known, physiological acceptors
    1.8.98.4  coenzyme F420:CoB-CoM heterodisulfide,ferredoxin reductase
     K03389  hdrB2; heterodisulfide reductase subunit B2
    1.8.98.5  H2:CoB-CoM heterodisulfide,ferredoxin reductase
     K03389  hdrB2; heterodisulfide reductase subunit B2
    1.8.98.6  formate:CoB-CoM heterodisulfide,ferredoxin reductase
     K03389  hdrB2; heterodisulfide reductase subunit B2
Other DBs
RN: R11928 R11931 R11943 R11944
COG: COG2048
Genes
TIG: THII_2280
THIS: HZT40_21385
TVI: Thivi_3111
TMB: Thimo_0248
TSY: THSYN_16425
HHC: M911_11215 M911_11235
EBS: ECTOBSL9_0282 ECTOBSL9_0286
TGR: Tgr7_2211 Tgr7_2215
TKM: TK90_0633 TK90_0637
TNI: TVNIR_3244(hdrB_[H]) TVNIR_3248(hdlB_[H])
SLIM: SCL_2520
TBN: TBH_C2777
ENM: EBS_2145(hdrB)
SHD: SUTH_02769(hdrB)
TBD: Tbd_1645
SDR: SCD_n01881(hdrB)
SLAC: SKTS_06180(hdrB) SKTS_11890
GSU: GSU0091(hdrB)
GSK: KN400_0066(hdrB)
GME: Gmet_3425(hdrB)
GLO: Glov_0862
GBM: Gbem_0031(hdrB)
GEO: Geob_3724(hdrB)
GEM: GM21_0030
GBN: GEOBRER4_00290(hdrB)
DVU: DVU2403(hdrB)
DVL: Dvul_0827
DVM: DvMF_0323
DDS: Ddes_2099
DMA: DMR_01910(hdrB)
DGG: DGI_1049(hdrB)
DTR: RSDT_0566(hdrB)
DAS: Daes_0784
DPI: BN4_11859(hdrB)
DOL: Dole_1160
DML: Dmul_28870(hdrB)
DAT: HRM2_22770(hdrD2')
SFU: Sfum_0819
BLAG: BLTE_14980
ATX: GCD22_01577(hdrB1) GCD22_02661(hdrB1) GCD22_03145(hdrB) GCD22_03149(hdrB1) GCD22_03192(hdrB1)
RCH: RUM_10960
RUM: CK1_05040
BPRO: PMF13cell1_01670(lutA)
SWO: Swol_0395
SALQ: SYNTR_0262
PTH: PTH_1412(HdrB)
SGY: Sgly_1901
HMO: HM1_2007
HCV: FTV88_1703(hdrB)
CHY: CHY_0929
ADG: Adeg_1334
TACI: TDSAC_1307
STED: SPTER_13750(sdhE_1)
DFO: Dform_00942(hdrB)
OTE: Oter_3676
TTF: THTE_4308
APS: CFPG_239
AFD: Alfi_2100
CTE: CT1245
CPC: Cpar_0950
CCH: Cag_1028
CLI: Clim_1201
PVI: Cvib_0844
PLT: Plut_1108
PPH: Ppha_1307
AAE: aq_400(hdrB)
HTH: HTH_1878(hdrB1) HTH_1882(hdrB2)
TTK: TST_1519(hdrB)
CABY: Cabys_1918
MMP: MMP1053(hdrB2) MMP1155(hdrB1)
MMAK: MMKA1_12180(hdrB) MMKA1_13330(hdrB)
MMAO: MMOS7_11480(hdrB) MMOS7_12630(hdrB)
MMAD: MMJJ_16900 MMJJ_17970(lutA)
MAE: Maeo_0308
METF: CFE53_06410(hdrB)
MTH: MTH_1879
MMG: MTBMA_c04500(hdrB)
METC: MTCT_1717
MWO: MWSIV6_0410(hdrB)
METE: tca_01815(lutA)
METK: FVF72_02310(hdrB)
MTHM: FZP57_01925(hdrB)
MST: Msp_1013(hdrB1)
MRU: mru_0817(hdrB1)
MSI: Msm_0795
MEB: Abm4_1308(hdrB2)
MMIL: sm9_1716(hdrB3)
MEYE: TL18_07635
MOL: YLM1_0405
METH: MBMB1_1274(hdrB)
MFC: BRM9_0490(hdrB1)
MFI: DSM1535_0471(hdrB)
MCUB: MCBB_1489(hdrB3)
METT: CIT01_08470(hdrB)
METO: CIT02_11685(hdrB)
MFV: Mfer_0739
MKA: MK0572(hdrB)
AFU: AF_1375
MBAR: MSBR2_3160
MBAK: MSBR3_3156
MAC: MA_4237(hdrB)
METM: MSMTP_0364
MTHR: MSTHT_1573
MTHE: MSTHC_1716
MFZ: AOB57_006960(hdrB)
MBU: Mbur_1517(hdrB)
MMET: MCMEM_1990
MMH: Mmah_1786
MZI: HWN40_01880(hdrB)
MTP: Mthe_1573
MCJ: MCON_3283(hdrB)
MHI: Mhar_0604
MHU: Mhun_1837
MLA: Mlab_0240
MBG: BN140_1727(hdrB)
MEMA: MMAB1_2222(hdrB)
MBN: Mboo_0589
MPL: Mpal_2240
MPD: MCP_1577(hdrB-1) MCP_2769(hdrB-3)
MEZ: Mtc_2474(hdrB-2)
RCI: RCIX595(hdrB-2) RRC257(hdrB-3)
MEAR: Mpt1_c02970(hdrB1) Mpt1_c08830(hdrB2)
MARC: AR505_0274
ABI: Aboo_0976
SSO: SSO1129(hdrB-1) SSO1135(hdrB-2)
SAI: Saci_0325(hdrB) Saci_0329
KCR: Kcr_0767
BARC: AOA65_1401(hdrB_2) AOA65_1887(hdrB_3) AOA65_1993(hdrB_4)
BARB: AOA66_1507(hdrB_1) AOA66_1731(hdrB_2)
LOKI: Lokiarch_01260(hdrB_1) Lokiarch_23590(hdrB_2) Lokiarch_39150(hdrB_3) Lokiarch_45510(hdrB_4)
PSYT: DSAG12_01137(hdrB_1) DSAG12_01146(hdrB_2) DSAG12_01161(hdrB_3) DSAG12_02807(hdrB_4) DSAG12_03223(hdrB_5) DSAG12_03725(hdrB_6) DSAG12_03952(hdrB_7)
 » show all
Reference
PMID:2121478
  Authors
Hedderich R, Berkessel A, Thauer RK
  Title
Purification and properties of heterodisulfide reductase from Methanobacterium thermoautotrophicum (strain Marburg).
  Journal
Eur J Biochem 193:255-61 (1990)
DOI:10.1111/j.1432-1033.1990.tb19331.x
  Sequence
Reference
PMID:8119281
  Authors
Setzke E, Hedderich R, Heiden S, Thauer RK
  Title
H2: heterodisulfide oxidoreductase complex from Methanobacterium thermoautotrophicum. Composition and properties.
  Journal
Eur J Biochem 220:139-48 (1994)
DOI:10.1111/j.1432-1033.1994.tb18608.x
  Sequence
Reference
  Authors
Mander GJ, Pierik AJ, Huber H, Hedderich R
  Title
Two distinct heterodisulfide reductase-like enzymes in the sulfate-reducing archaeon Archaeoglobus profundus.
  Journal
Eur J Biochem 271:1106-16 (2004)
DOI:10.1111/j.1432-1033.2004.04013.x
  Sequence
[apo:Arcpr_1553] [afu:AF_1375]

KEGG   ORTHOLOGY: K03390
Entry
K03390                      KO                                     

Name
hdrC2
Definition
heterodisulfide reductase subunit C2 [EC:1.8.7.3 1.8.98.4 1.8.98.5 1.8.98.6]
Pathway
ko00680  Methane metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01200  Carbon metabolism
Module
M00356  Methanogenesis, methanol => methane
M00357  Methanogenesis, acetate => methane
M00563  Methanogenesis, methylamine/dimethylamine/trimethylamine => methane
M00567  Methanogenesis, CO2 => methane
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00680 Methane metabolism
    K03390  hdrC2; heterodisulfide reductase subunit C2
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.8  Acting on a sulfur group of donors
   1.8.7  With an iron-sulfur protein as acceptor
    1.8.7.3  ferredoxin:CoB-CoM heterodisulfide reductase
     K03390  hdrC2; heterodisulfide reductase subunit C2
   1.8.98  With other, known, physiological acceptors
    1.8.98.4  coenzyme F420:CoB-CoM heterodisulfide,ferredoxin reductase
     K03390  hdrC2; heterodisulfide reductase subunit C2
    1.8.98.5  H2:CoB-CoM heterodisulfide,ferredoxin reductase
     K03390  hdrC2; heterodisulfide reductase subunit C2
    1.8.98.6  formate:CoB-CoM heterodisulfide,ferredoxin reductase
     K03390  hdrC2; heterodisulfide reductase subunit C2
Other DBs
RN: R11928 R11931 R11943 R11944
COG: COG1150
Genes
TMB: Thimo_0247
HHC: M911_11220
EBS: ECTOBSL9_0283
TGR: Tgr7_2212
TKM: TK90_0636
TNI: TVNIR_3245(hdlC_[H])
TVR: TVD_10630
APRS: BI364_13795
ACII: C4901_12960
SULF: CAP31_01860
SPLB: SFPGR_29430(hdrC)
SNIV: SFSGTM_27270(hdrC)
SLAC: SKTS_06170
GSU: GSU0092(hdrC)
GSK: KN400_0067(hdrC)
GME: Gmet_3424(hdrC)
GLO: Glov_0861
GBM: Gbem_0032(hdrC)
GEO: Geob_3725(hdrC)
GEM: GM21_0031
GBN: GEOBRER4_00300(hdrC)
DVU: DVU2404(hdrC)
DVL: Dvul_0826
DVM: DvMF_0322
DDS: Ddes_2098
DMA: DMR_01900(hdrC)
DGG: DGI_1048(hdrC)
DTR: RSDT_0565(hdrC)
DAS: Daes_0783
DPI: BN4_11858(hdrC)
DSF: UWK_01755
DOL: Dole_1161
DML: Dmul_28880(hdrC)
DAT: HRM2_22760(hdrD2)
DTO: TOL2_C17910(hdlC)
SFU: Sfum_0820
DBR: Deba_2022
HDN: Hden_0693
BLAG: BLTE_14840
RHC: RGUI_1279
AFR: AFE_2551
ACU: Atc_2348
ATX: GCD22_03146(hdlC)
RCH: RUM_10970
RUM: CK1_05050
BPRO: PMF13cell1_01671(rsxC_1)
SWO: Swol_0394
SLP: Slip_2075
SALQ: SYNTR_0261
PTH: PTH_1413(GlpC)
DAU: Daud_0563
SGY: Sgly_1902
HMO: HM1_2006
CHY: CHY_0927
DFO: Dform_00943(hdrC)
APS: CFPG_238
AAE: aq_391 aq_398(hdrC)
HTH: HTH_1879(hdrC1) HTH_1883(hdrC2)
TTK: TST_1518(hdrC)
BANA: BARAN1_0333(hdrC)
MMP: MMP1054(hdrC2) MMP1154(hdrC1)
MMAK: MMKA1_12190(hdrC) MMKA1_13320(hdrC)
MMAO: MMOS7_11490(hdrC) MMOS7_12620(hdrC)
MAE: Maeo_0307
METF: CFE53_02215(hdrC) CFE53_06415(hdrC)
MTH: MTH_1878
MMG: MTBMA_c04490(hdrC)
METC: MTCT_1716
MWO: MWSIV6_0409(hdrC)
METE: tca_01814
METK: FVF72_02315(hdrC)
MTHM: FZP57_01920(hdrC)
MST: Msp_1014(hdrC1)
MRU: mru_0816(hdrC)
MSI: Msm_0796
MEB: Abm4_1309(hdrC2)
MMIL: sm9_1717(hdrC2)
MEYE: TL18_07640
MOL: YLM1_0404
METH: MBMB1_1275
MFC: BRM9_0491(hdrC1)
MFI: DSM1535_0472(hdrC)
MCUB: MCBB_1490(hdrC3)
METT: CIT01_08465(hdrC)
METO: CIT02_11680(hdrC)
MFV: Mfer_0740
MKA: MK0573(hdrC)
AFU: AF_1376
GAH: GAH_01704
MBAR: MSBR2_3161
MBAK: MSBR3_3157
MAC: MA_4236(hdrC)
MMA: MM_0979
METM: MSMTP_0365
MTHR: MSTHT_1572
MTHE: MSTHC_1717
MFZ: AOB57_006955(hdrC)
MBU: Mbur_1516(hdrC)
MMET: MCMEM_1991
MMH: Mmah_1787
MZI: HWN40_01885(hdrC)
MTP: Mthe_1574
MCJ: MCON_3282(hdrC)
MHI: Mhar_0605
MHU: Mhun_1836
MLA: Mlab_0239
MBG: BN140_1726(hdrC)
MEMA: MMAB1_2221(hdrC)
MBN: Mboo_0590
MPL: Mpal_2241
MPD: MCP_1578(hdrC-1) MCP_2770(hdrC-3)
MEZ: Mtc_2475(hdrC-2)
RCI: RCIX594(hdrC-2) RRC256(hdrC-3)
MEAR: Mpt1_c02960(hdrC1) Mpt1_c08840(hdrC2)
MARC: AR505_0273
ABI: Aboo_0975
SSO: SSO1127(hdrC-1) SSO1134(hdrC-2)
SAI: Saci_0326 Saci_0334(hdrC)
VDI: Vdis_0690
VMO: VMUT_2339
KCR: Kcr_0766
BARC: AOA65_0030(hdrC_1) AOA65_1400(hdrC_2) AOA65_1888(hdrC_3) AOA65_1994(hdrC_4)
BARB: AOA66_1508(hdrC_1) AOA66_1732(hdrC_2)
LOKI: Lokiarch_01250(hdrC_1) Lokiarch_03060(hdrC_2) Lokiarch_23580(hdrC_3) Lokiarch_23870(hdrC_4) Lokiarch_39160(hdrC_5) Lokiarch_45500(hdrC_6)
PSYT: DSAG12_01138(hdrC_1) DSAG12_01145(hdrC_2) DSAG12_01162(hdrC_3) DSAG12_02806(hdrC_4) DSAG12_03218(hdrC_5) DSAG12_03726(hdrC_6) DSAG12_03953(hdrC_7)
 » show all
Reference
PMID:2121478
  Authors
Hedderich R, Berkessel A, Thauer RK
  Title
Purification and properties of heterodisulfide reductase from Methanobacterium thermoautotrophicum (strain Marburg).
  Journal
Eur J Biochem 193:255-61 (1990)
DOI:10.1111/j.1432-1033.1990.tb19331.x
  Sequence
Reference
PMID:8119281
  Authors
Setzke E, Hedderich R, Heiden S, Thauer RK
  Title
H2: heterodisulfide oxidoreductase complex from Methanobacterium thermoautotrophicum. Composition and properties.
  Journal
Eur J Biochem 220:139-48 (1994)
DOI:10.1111/j.1432-1033.1994.tb18608.x
  Sequence
Reference
  Authors
Mander GJ, Pierik AJ, Huber H, Hedderich R
  Title
Two distinct heterodisulfide reductase-like enzymes in the sulfate-reducing archaeon Archaeoglobus profundus.
  Journal
Eur J Biochem 271:1106-16 (2004)
DOI:10.1111/j.1432-1033.2004.04013.x
  Sequence

KEGG   ENZYME: 1.8.7.3
Entry
EC 1.8.7.3                  Enzyme                                 

Name
ferredoxin:CoB-CoM heterodisulfide reductase;
hdrABC (gene names);
hdrA1B1C1 (gene names);
hdrA2B2C2 (gene names)
Class
Oxidoreductases;
Acting on a sulfur group of donors;
With an iron-sulfur protein as acceptor
Sysname
CoB,CoM:ferredoxin oxidoreductase
Reaction(IUBMB)
2 oxidized ferredoxin [iron-sulfur] cluster + CoB + CoM = 2 reduced ferredoxin [iron-sulfur] cluster + CoM-S-S-CoB + 2 H+ [RN:R11931]
Reaction(KEGG)
R11931
Substrate
oxidized ferredoxin [iron-sulfur] cluster [CPD:C00139];
CoB [CPD:C04628];
CoM [CPD:C03576]
Product
reduced ferredoxin [iron-sulfur] cluster [CPD:C00138];
CoM-S-S-CoB [CPD:C04832];
H+ [CPD:C00080]
Comment
HdrABC is an enzyme complex that is found in most methanogens and catalyses the reduction of the CoB-CoM heterodisulfide back to CoB and CoM. HdrA contains a FAD cofactor that acts as the entry point for electrons, which are transferred via HdrC to the HdrB catalytic subunit. One form of the enzyme from Methanosarcina acetivorans (HdrA2B2C2) can also catalyse EC 1.8.98.4, coenzyme F420:CoB-CoM heterodisulfide,ferredoxin reductase. cf. EC 1.8.98.5, H2:CoB-CoM heterodisulfide,ferredoxin reductase, EC 1.8.98.6, formate:CoB-CoM heterodisulfide,ferredoxin reductase, and EC 1.8.98.1, dihydromethanophenazine:CoB-CoM heterodisulfide reductase.
History
EC 1.8.7.3 created 2017
Pathway
ec00680  Methane metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K03388  heterodisulfide reductase subunit A2
K03389  heterodisulfide reductase subunit B2
K03390  heterodisulfide reductase subunit C2
K22480  heterodisulfide reductase subunit A1
K22481  heterodisulfide reductase subunit B1
K22482  heterodisulfide reductase subunit C1
Genes
TIG: THII_2280
THIS: HZT40_21385
TVI: Thivi_3111
TMB: Thimo_0247 Thimo_0248 Thimo_0253
TSY: THSYN_16425
HHC: M911_11215 M911_11220 M911_11230 M911_11235 M911_11240
EBS: ECTOBSL9_0282 ECTOBSL9_0283 ECTOBSL9_0285 ECTOBSL9_0286 ECTOBSL9_0287
TGR: Tgr7_2211 Tgr7_2212 Tgr7_2214 Tgr7_2215 Tgr7_2216
TKM: TK90_0632 TK90_0633 TK90_0634 TK90_0636 TK90_0637
TNI: TVNIR_3244(hdrB_[H]) TVNIR_3245(hdlC_[H]) TVNIR_3247(hdrA_[H]) TVNIR_3248(hdlB_[H]) TVNIR_3249
SLIM: SCL_2520
TBN: TBH_C2777
ENM: EBS_2145(hdrB)
CBX: Cenrod_2147(hdrA)
SHD: SUTH_02769(hdrB)
TBD: Tbd_1645
SDR: SCD_n01881(hdrB)
GSU: GSU0090(hdrA) GSU0091(hdrB) GSU0092(hdrC)
GSK: KN400_0065(hdrA) KN400_0066(hdrB) KN400_0067(hdrC)
GME: Gmet_2084(bamE) Gmet_3424(hdrC) Gmet_3425(hdrB) Gmet_3426(hdrA)
GBM: Gbem_0030(hdrA) Gbem_0031(hdrB) Gbem_0032(hdrC) Gbem_1447(bamE)
GEO: Geob_0215(bamE-1) Geob_0231(bamE-2) Geob_3723(hdrA) Geob_3724(hdrB) Geob_3725(hdrC)
DVU: DVU2402(hdrA) DVU2403(hdrB) DVU2404(hdrC)
DMA: DMR_01900(hdrC) DMR_01910(hdrB) DMR_01920(hdrA) DMR_22120
DGG: DGI_1048(hdrC) DGI_1049(hdrB) DGI_1050(hdrA)
DTR: RSDT_0565(hdrC) RSDT_0566(hdrB) RSDT_0567(hdrA)
DPI: BN4_11858(hdrC) BN4_11859(hdrB) BN4_11860(hdrA)
DPS: DP1010
DML: Dmul_02770(hdrA1) Dmul_24500(bamE) Dmul_28860(hdrA2) Dmul_28870(hdrB) Dmul_28880(hdrC)
DAT: HRM2_06460 HRM2_11710(hdrA1) HRM2_11850(hdrA2) HRM2_14330(hdrA3) HRM2_14340(hdrA3') HRM2_22750(hdrA4) HRM2_22760(hdrD2) HRM2_22770(hdrD2')
DTO: TOL2_C02630 TOL2_C03750(bamE1) TOL2_C11590(hdlA2) TOL2_C11620(hdlA3) TOL2_C11630(hdlA3?) TOL2_C17900(hdlA5) TOL2_C17910(hdlC) TOL2_C17920(hdlB) TOL2_C24180(hdlA6) TOL2_C25730(hdlA7) TOL2_C28760(hdlA8) TOL2_C28830(hdlA9) TOL2_C41400(bamE2) TOL2_C43540(bamE3)
ADE: Adeh_4164
ATX: GCD22_01577(hdrB1) GCD22_02661(hdrB1) GCD22_03145(hdrB) GCD22_03146(hdlC) GCD22_03148(hdrA) GCD22_03149(hdrB1) GCD22_03150 GCD22_03192(hdrB1) GCD22_03279(hdrA)
PTH: PTH_1410(HdrA) PTH_1412(HdrB) PTH_1413(GlpC)
STED: SPTER_13740 SPTER_13750(sdhE_1) SPTER_13760(mnmC)
DFO: Dform_00920(hdrA) Dform_00941(hdrA) Dform_00942(hdrB) Dform_00943(hdrC)
CTE: CT1245 CT1246(hdrA-2)
AAE: aq_391 aq_395(hdrA) aq_398(hdrC) aq_400(hdrB)
HTH: HTH_1878(hdrB1) HTH_1879(hdrC1) HTH_1881(hdrA) HTH_1882(hdrB2) HTH_1883(hdrC2)
CTHI: THC_1756
MMP: MMP0825(hdrA) MMP1053(hdrB2) MMP1054(hdrC2) MMP1154(hdrC1) MMP1155(hdrB1) MMP1697(hdrA)
MMAK: MMKA1_09100(hdrA) MMKA1_12180(hdrB) MMKA1_12190(hdrC) MMKA1_13320(hdrC) MMKA1_13330(hdrB) MMKA1_19310(hdrA)
MMAO: MMOS7_08880(hdrA) MMOS7_11480(hdrB) MMOS7_11490(hdrC) MMOS7_12620(hdrC) MMOS7_12630(hdrB) MMOS7_18120(hdrA)
MMG: MTBMA_c04490(hdrC) MTBMA_c04500(hdrB) MTBMA_c17680(hdrA)
MWO: MWSIV6_0409(hdrC) MWSIV6_0410(hdrB) MWSIV6_1762(hdrA)
METE: tca_01335(rsxB_2) tca_01814 tca_01815(lutA)
MST: Msp_0125(hdrC2) Msp_0126(hdrB2) Msp_0127(hdrA2) Msp_1013(hdrB1) Msp_1014(hdrC1) Msp_1476(hdrA1)
MRU: mru_0117(hdrA) mru_0816(hdrC) mru_0817(hdrB1)
MEB: Abm4_0693(hdrC1) Abm4_0694(hdrB1) Abm4_0695(hdrA1) Abm4_1308(hdrB2) Abm4_1309(hdrC2) Abm4_1691(hdrA2)
MMIL: sm9_0982(hdrC1) sm9_0983(hdrB1) sm9_0984(hdrA1) sm9_1716(hdrB3) sm9_1717(hdrC2) sm9_2251(hdrA2)
MFC: BRM9_0490(hdrB1) BRM9_0491(hdrC1) BRM9_1362(hdrC2) BRM9_1363(hdrB3) BRM9_1364(hdrA1) BRM9_2298(hdrA2)
MCUB: MCBB_1055(hdrC1) MCBB_1056(hdrB1) MCBB_1057(hdrA1) MCBB_1489(hdrB3) MCBB_1490(hdrC3) MCBB_2243(hdrA3)
MKA: MK0249(hdrA_1) MK0265(hdrA_2) MK0572(hdrB) MK0573(hdrC)
MAC: MA_2868(hdrA) MA_3126(hdrB) MA_3127(hdrC) MA_3128(hdrA) MA_4236(hdrC) MA_4237(hdrB)
MBU: Mbur_0552(hdrA) Mbur_1516(hdrC) Mbur_1517(hdrB)
MCJ: MCON_3279(hdrA) MCON_3282(hdrC) MCON_3283(hdrB)
MBG: BN140_0752(hdrA1) BN140_1726(hdrC) BN140_1727(hdrB) BN140_1728(hdrA3)
MEMA: MMAB1_0971(hdrA) MMAB1_2221(hdrC) MMAB1_2222(hdrB) MMAB1_2223(hdrA)
MPD: MCP_1576(hdrA-1) MCP_1577(hdrB-1) MCP_1578(hdrC-1) MCP_1989(hdrA_mvhD) MCP_1990(hdrB-2) MCP_1991(hdrC-2) MCP_2768(hdrA-2) MCP_2769(hdrB-3) MCP_2770(hdrC-3)
MEZ: Mtc_1469(hdrC-1) Mtc_1470(hdrB-1) Mtc_1471(hdrA1) Mtc_2473(hdrA-2) Mtc_2474(hdrB-2) Mtc_2475(hdrC-2)
RCI: LRC437(hdrA-1) LRC438(hdrB-1) LRC439(hdrC-1) RCIX594(hdrC-2) RCIX595(hdrB-2) RCIX596(hdrA-2) RRC256(hdrC-3) RRC257(hdrB-3) RRC258(hdrA-3)
HDF: AArcSl_1855(hdrA)
MEAR: Mpt1_c02960(hdrC1) Mpt1_c02970(hdrB1) Mpt1_c08830(hdrB2) Mpt1_c08840(hdrC2) Mpt1_c10580(hdrA)
SSO: SSO1127(hdrC-1) SSO1129(hdrB-1) SSO1131(hdrA) SSO1134(hdrC-2) SSO1135(hdrB-2)
BARC: AOA65_0030(hdrC_1) AOA65_1112(hdrA_1) AOA65_1400(hdrC_2) AOA65_1401(hdrB_2) AOA65_1402(hdrA_3) AOA65_1719(hdlA_2) AOA65_1887(hdrB_3) AOA65_1888(hdrC_3) AOA65_1993(hdrB_4) AOA65_1994(hdrC_4) AOA65_1995(hdrA_4)
BARB: AOA66_0155(hdrA_1) AOA66_1507(hdrB_1) AOA66_1508(hdrC_1) AOA66_1510(hdrA_2) AOA66_1512(hdlA_2) AOA66_1513(hdrA_3) AOA66_1526(hdrA_4) AOA66_1731(hdrB_2) AOA66_1732(hdrC_2)
LOKI: Lokiarch_00290(hdrA_1) Lokiarch_01240(hdrA_2) Lokiarch_01250(hdrC_1) Lokiarch_01260(hdrB_1) Lokiarch_03060(hdrC_2) Lokiarch_08680(hdrA_4) Lokiarch_09900(hdrA_5) Lokiarch_10040(hdlA_3) Lokiarch_17940(hdlA_5) Lokiarch_23580(hdrC_3) Lokiarch_23590(hdrB_2) Lokiarch_23600(hdrA_8) Lokiarch_23870(hdrC_4) Lokiarch_25880(hdrA_9) Lokiarch_28050(hdrA_10) Lokiarch_39150(hdrB_3) Lokiarch_39160(hdrC_5) Lokiarch_40200(hdrA_13) Lokiarch_41160(hdrA_15) Lokiarch_45500(hdrC_6) Lokiarch_45510(hdrB_4) Lokiarch_49330(hdrA_16)
PSYT: DSAG12_01136(hdrA_1) DSAG12_01137(hdrB_1) DSAG12_01138(hdrC_1) DSAG12_01145(hdrC_2) DSAG12_01146(hdrB_2) DSAG12_01147(hdrA_2) DSAG12_01161(hdrB_3) DSAG12_01162(hdrC_3) DSAG12_02253(hdrA_3) DSAG12_02805(hdrA_4) DSAG12_02806(hdrC_4) DSAG12_02807(hdrB_4) DSAG12_03218(hdrC_5) DSAG12_03220(hdrA_5) DSAG12_03223(hdrB_5) DSAG12_03721(hdrA_6) DSAG12_03723(hdlA_4) DSAG12_03724(hdrA_7) DSAG12_03725(hdrB_6) DSAG12_03726(hdrC_6) DSAG12_03952(hdrB_7) DSAG12_03953(hdrC_7)
 » show all
Reference
1  [PMID:19968794]
  Authors
Buan NR, Metcalf WW
  Title
Methanogenesis by Methanosarcina acetivorans involves two structurally and functionally distinct classes of heterodisulfide reductase.
  Journal
Mol Microbiol 75:843-53 (2010)
DOI:10.1111/j.1365-2958.2009.06990.x
  Sequence
Reference
2  [PMID:28174314]
  Authors
Yan Z, Wang M, Ferry JG.
  Title
A Ferredoxin- and F420H2-Dependent, Electron-Bifurcating, Heterodisulfide Reductase with Homologs in the Domains Bacteria and Archaea.
  Journal
mBio 8:e02285-16 (2017)
DOI:10.1128/mBio.02285-16
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.8.7.3
IUBMB Enzyme Nomenclature: 1.8.7.3
ExPASy - ENZYME nomenclature database: 1.8.7.3
BRENDA, the Enzyme Database: 1.8.7.3

KEGG   REACTION: R11931
Entry
R11931                      Reaction                               

Name
CoB,CoM:ferredoxin oxidoreductase
Definition
Coenzyme B + Coenzyme M + 2 Oxidized ferredoxin <=> Coenzyme M 7-mercaptoheptanoylthreonine-phosphate heterodisulfide + 2 Reduced ferredoxin + 2 H+
Equation
C04628 + C03576 + 2 C00139 <=> C04832 + 2 C00138 + 2 C00080
Reaction class
RC00011  C03576_C04832  C04628_C04832
Enzyme
Pathway
rn00680  Methane metabolism
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
Module
M00356  Methanogenesis, methanol => methane
M00357  Methanogenesis, acetate => methane
M00563  Methanogenesis, methylamine/dimethylamine/trimethylamine => methane
M00567  Methanogenesis, CO2 => methane
Orthology
K03388  heterodisulfide reductase subunit A2 [EC:1.8.7.3 1.8.98.4 1.8.98.5 1.8.98.6]
K03389  heterodisulfide reductase subunit B2 [EC:1.8.7.3 1.8.98.4 1.8.98.5 1.8.98.6]
K03390  heterodisulfide reductase subunit C2 [EC:1.8.7.3 1.8.98.4 1.8.98.5 1.8.98.6]
K22480  heterodisulfide reductase subunit A1 [EC:1.8.7.3]
K22481  heterodisulfide reductase subunit B1 [EC:1.8.7.3]
K22482  heterodisulfide reductase subunit C1 [EC:1.8.7.3]
Other DBs
RHEA: 55163

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