KEGG   ORTHOLOGY: K22516
Entry
K22516                      KO                                     

Name
fdhA
Definition
formate dehydrogenase (coenzyme F420) alpha subunit [EC:1.17.98.3 1.8.98.6]
Pathway
ko00680  Methane metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01200  Carbon metabolism
Module
M00356  Methanogenesis, methanol => methane
M00357  Methanogenesis, acetate => methane
M00563  Methanogenesis, methylamine/dimethylamine/trimethylamine => methane
M00567  Methanogenesis, CO2 => methane
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00680 Methane metabolism
    K22516  fdhA; formate dehydrogenase (coenzyme F420) alpha subunit
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.8  Acting on a sulfur group of donors
   1.8.98  With other, known, physiological acceptors
    1.8.98.6  formate:CoB-CoM heterodisulfide,ferredoxin reductase
     K22516  fdhA; formate dehydrogenase (coenzyme F420) alpha subunit
  1.17  Acting on CH or CH2 groups
   1.17.98  With other, known, physiological acceptors
    1.17.98.3  formate dehydrogenase (coenzyme F420)
     K22516  fdhA; formate dehydrogenase (coenzyme F420) alpha subunit
Other DBs
RN: R10797 R11944
COG: COG3383
GO: 0043794
Genes
VNA: PN96_21155
VEJ: VEJY3_20411
PGB: H744_1c0419
PSH: Psest_3905
PSTU: UIB01_19765
PCH: EY04_14750
PSED: DM292_16890
GNI: GNIT_2862
CHIZ: HQ393_09255
CFON: HZU75_11945
CCO: CCC13826_0200(fdhH)
CCOC: CCON33237_0536(fdhH)
CGRA: CGRAC_1361(fdhH)
CPIN: CPIN18020_0262(fdhH)
CGEO: CGEO_1649(fdhH)
CMUC: CMCT_1635(fdhH)
AHS: AHALO_1025(fdhH)
AMAR: AMRN_1963(fdhH)
ACAA: ACAN_2017(fdhH)
SULJ: SJPD1_1032
GEO: Geob_0149
PCA: Pcar_2701
DSF: UWK_03159
DAT: HRM2_11880(fdhA3) HRM2_14370(fdhA4)
EFS: EFS1_1216
ENE: ENT_08450
CSQ: CSCA_0253
DSY: DSY1990
DHD: Dhaf_3153
SFI: SFUL_466
MJA: MJ_0006
MMP: MMP0138(fdhA) MMP1298(fdhA)
MMAK: MMKA1_01430(fdhA) MMKA1_15230(fdhA)
MMAO: MMOS7_01690(fdhA) MMOS7_14050(fdhA)
MMAD: MMJJ_09470(fdhF_2) MMJJ_15440(fdhA2)
MAE: Maeo_0578
MTH: MTH_1140
MMG: MTBMA_c15230(fdhA2)
METE: tca_01096
MST: Msp_0640(fdhA)
MRU: mru_0333(fdhA1) mru_2074(fdhA2)
MEB: Abm4_0131(fdhA) Abm4_0855(fdhA2)
MMIL: sm9_1350(flpA) sm9_2183(fdhA)
MEYE: TL18_01670
METH: MBMB1_0104(fdhA)
MFC: BRM9_0168(fdhA)
MFI: DSM1535_1486(fdhA)
MCUB: MCBB_2028(fdhA)
MKA: MK0321
FPL: Ferp_0094
PYN: PNA2_1925
PYS: Py04_1234
TKO: TK2076
TGA: TGAM_0065(mhy2A) TGAM_0249(fdh1A) TGAM_0631(fdhA)
TSI: TSIB_0067
PPAC: PAP_03230
MBAR: MSBR2_2855
MMAC: MSMAC_2582
METM: MSMTP_1177
MHOR: MSHOH_1794
MPY: Mpsy_2944
MTP: Mthe_1339
MCJ: MCON_2237(fdhA)
MBG: BN140_0842(fdhA) BN140_1327(fdhA1) BN140_1329(fdhA2) BN140_2198(fdhA3)
MEMA: MMAB1_1106(fdhA) MMAB1_1689(fdhA) MMAB1_2914(fdhA)
MBN: Mboo_0923
MPD: MCP_1570(fdhA-1) MCP_2407(fdhA-2)
MEZ: Mtc_2125(fdhA)
RCI: RCIX1628(fdhA-1) RCIX2373(fdhA-2) RCIX2378(fdhA-3) RRC251(fdhA-4)
HHB: Hhub_2705(fdhA)
HALH: HTSR_1736(fdhA) HTSR_1740(fdhA2)
HHSR: HSR6_1802(fdoG2) HSR6_1806(fdoG3)
HHI: HAH_5041(fdhA)
NMO: Nmlp_2714(fdhA)
HLA: Hlac_1238
HALQ: Hrr1229_013155(fdhF)
HALU: HUG12_20610(fdhF)
HDF: AArcSl_0465(fdoG) AArcSl_1489(fdoG2)
HTU: Htur_0685
HALY: HYG82_00570(fdhF)
TAC: Ta0045
TVO: TVG0003442(TVG0003442)
FAI: FAD_1471
ABI: Aboo_0808
IHO: Igni_1101
IIS: EYM_07315
MSE: Msed_1457
AHO: Ahos_2012
VDI: Vdis_2449
TPE: Tpen_0190
 » show all
Reference
  Authors
Lupa B, Hendrickson EL, Leigh JA, Whitman WB
  Title
Formate-dependent H2 production by the mesophilic methanogen Methanococcus maripaludis.
  Journal
Appl Environ Microbiol 74:6584-90 (2008)
DOI:10.1128/AEM.01455-08
Reference
  Authors
Costa KC, Lie TJ, Xia Q, Leigh JA
  Title
VhuD facilitates electron flow from H2 or formate to heterodisulfide reductase in Methanococcus maripaludis.
  Journal
J Bacteriol 195:5160-5 (2013)
DOI:10.1128/JB.00895-13

KEGG   ORTHOLOGY: K00125
Entry
K00125                      KO                                     

Name
fdhB
Definition
formate dehydrogenase (coenzyme F420) beta subunit [EC:1.17.98.3 1.8.98.6]
Pathway
ko00680  Methane metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01200  Carbon metabolism
Module
M00356  Methanogenesis, methanol => methane
M00357  Methanogenesis, acetate => methane
M00563  Methanogenesis, methylamine/dimethylamine/trimethylamine => methane
M00567  Methanogenesis, CO2 => methane
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00680 Methane metabolism
    K00125  fdhB; formate dehydrogenase (coenzyme F420) beta subunit
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.8  Acting on a sulfur group of donors
   1.8.98  With other, known, physiological acceptors
    1.8.98.6  formate:CoB-CoM heterodisulfide,ferredoxin reductase
     K00125  fdhB; formate dehydrogenase (coenzyme F420) beta subunit
  1.17  Acting on CH or CH2 groups
   1.17.98  With other, known, physiological acceptors
    1.17.98.3  formate dehydrogenase (coenzyme F420)
     K00125  fdhB; formate dehydrogenase (coenzyme F420) beta subunit
Other DBs
RN: R10797 R11944
COG: COG1035 COG1139
GO: 0043794
Genes
TMB: Thimo_0255
SLAC: SKTS_06260
DDE: Dde_1211 Dde_3528
DMA: DMR_01940
DGG: DGI_1052(floxC)
DFL: DFE_0758 DFE_2489
DCB: C3Y92_00575
DMS: E8L03_02850
DSD: GD606_00175 GD606_07840 GD606_11690
DSA: Desal_0598
DAS: Daes_0781
DPI: BN4_11862
DBA: Dbac_2346
DRT: Dret_0419
DAL: Dalk_5062
DAT: HRM2_22740(fdhB6)
DBR: Deba_2134
BLAG: BLTE_14910
RCH: RUM_11000
RUM: CK1_05080
SWO: Swol_0400
SALQ: SYNTR_0266
PTH: PTH_1407(RnfC)
DAU: Daud_0567
SGY: Sgly_1898
HMO: HM1_2010
CTHM: CFE_1626
CHY: CHY_0932
ADG: Adeg_1331
MJA: MJ_0005
MMP: MMP0139(fdhB) MMP1297(fdhB)
MMAK: MMKA1_01440(fdhB) MMKA1_15220(fdhB)
MMAO: MMOS7_01700(fdhB) MMOS7_14040(fdhB)
MMAD: MMJJ_09460 MMJJ_15460(fdhB1)
MAE: Maeo_0577
MTH: MTH_1139
MMG: MTBMA_c15220(fdhB)
MWO: MWSIV6_0698(fdhB1) MWSIV6_1531(fdhB3)
METE: tca_01095
MST: Msp_0639(fdhB)
MRU: mru_0334(fdhB1) mru_2075(fdhB2)
MEB: Abm4_0132(fdhB) Abm4_0854(fdhB2)
MMIL: sm9_1349(flpB) sm9_2182(fdhB)
METH: MBMB1_0103(fdhB)
MFC: BRM9_0167(fdhB)
MFI: DSM1535_1485(fdhB)
MCUB: MCBB_2029(fdhB1) MCBB_2031(fdhB3)
MKA: MK0322
MBAR: MSBR2_2854
MMAC: MSMAC_2581
MHOR: MSHOH_1795
MPY: Mpsy_2943
MHI: Mhar_0324
MBG: BN140_0841(fdhB) BN140_1328(fdhB1) BN140_1330(fdhB2) BN140_2197(fdhB3)
MEMA: MMAB1_1105(fdhB) MMAB1_1690(fdhB) MMAB1_2913(fdhB)
MBN: Mboo_0924
MPD: MCP_1569(fdhB-1) MCP_2406(fdhB-2)
MEZ: Mtc_2124(fdhB)
RCI: RCIX1630(fdhB-1) RCIX2372(fdhB-2) RCIX2376(fdhB-3) RRC252(fdhB-4)
ABI: Aboo_0980
PSYT: DSAG12_02784(fdhB_1) DSAG12_03719(fdhB_2)
 » show all
Reference
  Authors
Lupa B, Hendrickson EL, Leigh JA, Whitman WB
  Title
Formate-dependent H2 production by the mesophilic methanogen Methanococcus maripaludis.
  Journal
Appl Environ Microbiol 74:6584-90 (2008)
DOI:10.1128/AEM.01455-08
Reference
  Authors
Costa KC, Lie TJ, Xia Q, Leigh JA
  Title
VhuD facilitates electron flow from H2 or formate to heterodisulfide reductase in Methanococcus maripaludis.
  Journal
J Bacteriol 195:5160-5 (2013)
DOI:10.1128/JB.00895-13

KEGG   ENZYME: 1.17.98.3
Entry
EC 1.17.98.3                Enzyme                                 

Name
formate dehydrogenase (coenzyme F420);
coenzyme F420 reducing formate dehydrogenase;
coenzyme F420-dependent formate dehydrogenase
Class
Oxidoreductases;
Acting on CH or CH2 groups;
With other, known, physiological acceptors
Sysname
formate:coenzyme-F420 oxidoreductase
Reaction(IUBMB)
formate + oxidized coenzyme F420 = CO2 + reduced coenzyme F420 [RN:R10797]
Reaction(KEGG)
R10797
Substrate
formate [CPD:C00058];
oxidized coenzyme F420 [CPD:C00876]
Product
CO2 [CPD:C00011];
reduced coenzyme F420 [CPD:C01080]
Comment
The enzyme, characterized from methanogenic archaea, is involved in formate-dependent H2 production. It contains noncovalently bound FAD [1].
History
EC 1.17.98.3 created 2014 as EC 1.2.99.9, transferred 2017 to EC 1.17.98.3
Pathway
ec00680  Methane metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K00125  formate dehydrogenase (coenzyme F420) beta subunit
K22516  formate dehydrogenase (coenzyme F420) alpha subunit
Genes
VNA: PN96_21155
VEJ: VEJY3_20411
PGB: H744_1c0419
PSH: Psest_3905
PSTU: UIB01_19765
PCH: EY04_14750
PSED: DM292_16890
GNI: GNIT_2862
TMB: Thimo_0255
CHIZ: HQ393_09255
SLAC: SKTS_06260
CCO: CCC13826_0200(fdhH)
CCOC: CCON33237_0536(fdhH)
CGRA: CGRAC_1361(fdhH)
CPIN: CPIN18020_0262(fdhH)
CGEO: CGEO_1649(fdhH)
CMUC: CMCT_1635(fdhH)
AHS: AHALO_1025(fdhH)
AMAR: AMRN_1963(fdhH)
ACAA: ACAN_2017(fdhH)
SULJ: SJPD1_1032
GEO: Geob_0149
PCA: Pcar_2701
DMA: DMR_01940
DGG: DGI_1052(floxC)
DAS: Daes_0781
DPI: BN4_11862
DBA: Dbac_2346
DRT: Dret_0419
DSF: UWK_03159
DAL: Dalk_5062
DAT: HRM2_11880(fdhA3) HRM2_14370(fdhA4) HRM2_22740(fdhB6)
DBR: Deba_2134
BLAG: BLTE_14910
EFS: EFS1_1216
ENE: ENT_08450
CSQ: CSCA_0253
RCH: RUM_11000
RUM: CK1_05080
SWO: Swol_0400
SALQ: SYNTR_0266
DSY: DSY1990
DHD: Dhaf_3153
PTH: PTH_1407(RnfC)
DAU: Daud_0567
SGY: Sgly_1898
HMO: HM1_2010
CTHM: CFE_1626
CHY: CHY_0932
ADG: Adeg_1331
SFI: SFUL_466
MMP: MMP0138(fdhA) MMP0139(fdhB) MMP1297(fdhB) MMP1298(fdhA)
MMAK: MMKA1_01430(fdhA) MMKA1_01440(fdhB) MMKA1_15220(fdhB) MMKA1_15230(fdhA)
MMAO: MMOS7_01690(fdhA) MMOS7_01700(fdhB) MMOS7_14040(fdhB) MMOS7_14050(fdhA)
MMAD: MMJJ_09460 MMJJ_09470(fdhF_2) MMJJ_15440(fdhA2) MMJJ_15460(fdhB1)
MMG: MTBMA_c15220(fdhB) MTBMA_c15230(fdhA2)
MWO: MWSIV6_0697(fdhA5) MWSIV6_0698(fdhB1) MWSIV6_1531(fdhB3) MWSIV6_1532
MST: Msp_0639(fdhB) Msp_0640(fdhA)
MRU: mru_0333(fdhA1) mru_0334(fdhB1) mru_2074(fdhA2) mru_2075(fdhB2)
MEB: Abm4_0131(fdhA) Abm4_0132(fdhB) Abm4_0854(fdhB2) Abm4_0855(fdhA2)
MMIL: sm9_1349(flpB) sm9_1350(flpA) sm9_2182(fdhB) sm9_2183(fdhA)
METH: MBMB1_0103(fdhB) MBMB1_0104(fdhA)
MFC: BRM9_0167(fdhB) BRM9_0168(fdhA)
MFI: DSM1535_1485(fdhB) DSM1535_1486(fdhA)
MCUB: MCBB_2028(fdhA) MCBB_2029(fdhB1) MCBB_2031(fdhB3)
FPL: Ferp_0094
PYN: PNA2_1925
PYS: Py04_1234
TKO: TK2076
TGA: TGAM_0065(mhy2A) TGAM_0249(fdh1A) TGAM_0631(fdhA)
TSI: TSIB_0067
PPAC: PAP_03230
METM: MSMTP_1177
MTP: Mthe_1339
MCJ: MCON_2237(fdhA)
MBG: BN140_0841(fdhB) BN140_0842(fdhA) BN140_1327(fdhA1) BN140_1328(fdhB1) BN140_1329(fdhA2) BN140_1330(fdhB2) BN140_2197(fdhB3) BN140_2198(fdhA3)
MEMA: MMAB1_1105(fdhB) MMAB1_1106(fdhA) MMAB1_1689(fdhA) MMAB1_1690(fdhB) MMAB1_2913(fdhB) MMAB1_2914(fdhA)
MPD: MCP_1569(fdhB-1) MCP_1570(fdhA-1) MCP_2406(fdhB-2) MCP_2407(fdhA-2)
MEZ: Mtc_2124(fdhB) Mtc_2125(fdhA)
RCI: RCIX1628(fdhA-1) RCIX1630(fdhB-1) RCIX2372(fdhB-2) RCIX2373(fdhA-2) RCIX2376(fdhB-3) RCIX2378(fdhA-3) RRC251(fdhA-4) RRC252(fdhB-4)
HHB: Hhub_2705(fdhA)
HALH: HTSR_1736(fdhA) HTSR_1740(fdhA2)
HHSR: HSR6_1802(fdoG2) HSR6_1806(fdoG3)
HHI: HAH_5041(fdhA)
NMO: Nmlp_2714(fdhA)
HLA: Hlac_1238
HALQ: Hrr1229_013155(fdhF)
HALU: HUG12_20610(fdhF)
HDF: AArcSl_0465(fdoG) AArcSl_1489(fdoG2)
HTU: Htur_0685
HALY: HYG82_00570(fdhF)
TAC: Ta0045
TVO: TVG0003442(TVG0003442)
FAI: FAD_1471
IHO: Igni_1101
IIS: EYM_07315
MSE: Msed_1457
AHO: Ahos_2012
VDI: Vdis_2449
TPE: Tpen_0190
PSYT: DSAG12_02784(fdhB_1) DSAG12_03719(fdhB_2)
 » show all
Reference
1  [PMID:6874636]
  Authors
Schauer NL, Ferry JG
  Title
FAD requirement for the reduction of coenzyme F420 by formate dehydrogenase from  Methanobacterium formicicum.
  Journal
J Bacteriol 155:467-72 (1983)
DOI:10.1128/JB.155.2.467-472.1983
Reference
2  [PMID:3944055]
  Authors
Schauer NL, Ferry JG
  Title
Composition of the coenzyme F420-dependent formate dehydrogenase from Methanobacterium formicicum.
  Journal
J Bacteriol 165:405-11 (1986)
DOI:10.1128/JB.165.2.405-411.1986
Reference
3  [PMID:18791018]
  Authors
Lupa B, Hendrickson EL, Leigh JA, Whitman WB
  Title
Formate-dependent H2 production by the mesophilic methanogen Methanococcus maripaludis.
  Journal
Appl Environ Microbiol 74:6584-90 (2008)
DOI:10.1128/AEM.01455-08
Other DBs
ExplorEnz - The Enzyme Database: 1.17.98.3
IUBMB Enzyme Nomenclature: 1.17.98.3
ExPASy - ENZYME nomenclature database: 1.17.98.3
BRENDA, the Enzyme Database: 1.17.98.3

KEGG   REACTION: R10797
Entry
R10797                      Reaction                               

Name
formate:coenzyme-F420 oxidoreductase
Definition
Formate + Coenzyme F420 <=> CO2 + Reduced coenzyme F420
Equation
Reaction class
RC02628  C00876_C01080
RC02796  C00011_C00058
Enzyme
Pathway
rn00680  Methane metabolism
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
Orthology
K00125  formate dehydrogenase (coenzyme F420) beta subunit [EC:1.17.98.3 1.8.98.6]
K22516  formate dehydrogenase (coenzyme F420) alpha subunit [EC:1.17.98.3 1.8.98.6]
Other DBs
RHEA: 42767

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