KEGG   ORTHOLOGY: K22602Help
Entry
K22602                      KO                                     

Name
hpxW
Definition
oxamate amidohydrolase [EC:3.5.1.126]
Pathway
ko00230  Purine metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    K22602  hpxW; oxamate amidohydrolase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K22602  hpxW; oxamate amidohydrolase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.1  In linear amides
    3.5.1.126  oxamate amidohydrolase
     K22602  hpxW; oxamate amidohydrolase
Peptidases and inhibitors [BR:ko01002]
 Threonine peptidases
  Family T3: gamma-glutamyltransferase family
   K22602  hpxW; oxamate amidohydrolase
BRITE hierarchy
Other DBs
RN: R11617
COG: COG0405
Genes
ENO: ECENHK_08050
ENL: A3UG_08000
ECLG: EC036_15400
ECLN: ECNIH4_14590
EAU: DI57_10815
EKB: BFV64_08030
EEC: EcWSU1_01577(ywrD)
ELG: BH714_03980
ERN: BFV67_07630
ECLS: LI67_009105
ENF: AKI40_4038(ggt)
EBG: FAI37_21530(hpxW)
KPN: KPN_01768
KPU: KP1_2816
KPP: A79E_2466
KPE: KPK_2602
KPR: KPR_2435
KPJ: N559_2533
KPX: PMK1_04107(ywrD)
KPNU: LI86_12615
KPNK: BN49_2857
KVA: Kvar_2544
KOX: KOX_16795
KOE: A225_2207
EAE: EAE_19155
EAR: CCG30051
KLW: DA718_17815(hpxW)
RTG: NCTC13098_04804(ywrD_3) NCTC13098_04805(ywrD_4)
REE: electrica_03267(ywrD)
CLAP: NCTC11466_03691(ywrD)
ICP: ICMP_513(ggt)
SBW: TGUWTKB_0820(ggt)
PSTS: E05_03740
YEY: Y11_21711
SPE: Spro_0930
SRL: SOD_c07840(ywrD)
SPLY: Q5A_004175(ywrD)
SMAF: D781_1713
RAA: Q7S_04405
ECA: ECA3497
PATR: EV46_17315
PATO: GZ59_35110
PCT: PC1_3315
PEC: W5S_3607
DDQ: DDI_3227
ETA: ETA_26240(ggt)
EPY: EpC_27490(ggt)
EPR: EPYR_02985(ggt)
EAM: EAMY_0856(ggt3)
EAY: EAM_0868
EBI: EbC_08570(ggt)
ERJ: EJP617_19850(ggt)
EGE: EM595_0850(ggt2)
PAM: PANA_0858(ggt)
PLF: PANA5342_3449(ggt7)
PAJ: PAJ_0193(ggt)
PVA: Pvag_0252(ggt1)
HHS: HHS_08180(ggt)
PSTW: DSJ_19490
TPTY: NCTC11468_02971(ywrD)
PSES: PSCI_5245
HAM: HALO3322
SVA: SVA_0806
BGP: BGL_2c05070(ywrD)
BXB: DR64_6370
BFN: OI25_5013
POH: DPM16_07050(ggt)
ODI: ODI_R4100
HRB: Hrubri_3752(ggt)
BPRC: D521_1842
OCA: OCAR_6970(ggt4)
OCG: OCA5_c11190(ggt3)
OCO: OCA4_c11190(ggt3)
RMM: ROSMUCSMR3_02132(ywrD)
RRF: F11_17005
MAGN: WV31_11540
AFS: AFR_16955
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Pope SD, Chen LL, Stewart V
  Title
Purine utilization by Klebsiella oxytoca M5al: genes for ring-oxidizing and -opening enzymes.
  Journal
J Bacteriol 191:1006-17 (2009)
DOI:10.1128/JB.01281-08
  Sequence
[kox:KOX_16795]
Reference
  Authors
Hicks KA, Ealick SE
  Title
Biochemical and structural characterization of Klebsiella pneumoniae oxamate amidohydrolase in the uric acid degradation pathway.
  Journal
Acta Crystallogr D Struct Biol 72:808-16 (2016)
DOI:10.1107/S2059798316007099
  Sequence
[kpn:KPN_01768]

KEGG   ENZYME: 3.5.1.126Help
Entry
EC 3.5.1.126                Enzyme                                 

Name
oxamate amidohydrolase;
HpxW
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
BRITE hierarchy
Sysname
oxamate amidohydrolase
Reaction(IUBMB)
oxamate + H2O = oxalate + NH3 [RN:R11617]
Reaction(KEGG)
Substrate
oxamate [CPD:C01444];
H2O [CPD:C00001]
Product
oxalate [CPD:C00209];
NH3 [CPD:C00014]
Comment
The enzyme has been characterized from the bacterium Klebsiella pneumoniae.
History
EC 3.5.1.126 created 2017
Pathway
ec00230  Purine metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K22602  oxamate amidohydrolase
Genes
ENO: ECENHK_08050
ENL: A3UG_08000
ECLG: EC036_15400
ECLN: ECNIH4_14590
EAU: DI57_10815
EKB: BFV64_08030
EEC: EcWSU1_01577(ywrD)
ELG: BH714_03980
ERN: BFV67_07630
ECLS: LI67_009105
ENF: AKI40_4038(ggt)
EBG: FAI37_21530(hpxW)
KPN: KPN_01768
KPU: KP1_2816
KPP: A79E_2466
KPE: KPK_2602
KPR: KPR_2435
KPJ: N559_2533
KPX: PMK1_04107(ywrD)
KPNU: LI86_12615
KPNK: BN49_2857
KVA: Kvar_2544
KOX: KOX_16795
KOE: A225_2207
EAE: EAE_19155
EAR: CCG30051
KLW: DA718_17815(hpxW)
RTG: NCTC13098_04804(ywrD_3) NCTC13098_04805(ywrD_4)
REE: electrica_03267(ywrD)
CLAP: NCTC11466_03691(ywrD)
ICP: ICMP_513(ggt)
SBW: TGUWTKB_0820(ggt)
PSTS: E05_03740
YEY: Y11_21711
SPE: Spro_0930
SRL: SOD_c07840(ywrD)
SPLY: Q5A_004175(ywrD)
SMAF: D781_1713
RAA: Q7S_04405
ECA: ECA3497
PATR: EV46_17315
PATO: GZ59_35110
PCT: PC1_3315
PEC: W5S_3607
DDQ: DDI_3227
ETA: ETA_26240(ggt)
EPY: EpC_27490(ggt)
EPR: EPYR_02985(ggt)
EAM: EAMY_0856(ggt3)
EAY: EAM_0868
EBI: EbC_08570(ggt)
ERJ: EJP617_19850(ggt)
EGE: EM595_0850(ggt2)
PAM: PANA_0858(ggt)
PLF: PANA5342_3449(ggt7)
PAJ: PAJ_0193(ggt)
PVA: Pvag_0252(ggt1)
HHS: HHS_08180(ggt)
PSTW: DSJ_19490
TPTY: NCTC11468_02971(ywrD)
PSES: PSCI_5245
HAM: HALO3322
SVA: SVA_0806
BGP: BGL_2c05070(ywrD)
BXB: DR64_6370
BFN: OI25_5013
POH: DPM16_07050(ggt)
ODI: ODI_R4100
HRB: Hrubri_3752(ggt)
BPRC: D521_1842
OCA: OCAR_6970(ggt4)
OCG: OCA5_c11190(ggt3)
OCO: OCA4_c11190(ggt3)
RMM: ROSMUCSMR3_02132(ywrD)
RRF: F11_17005
MAGN: WV31_11540
AFS: AFR_16955
 » show all
Taxonomy
Reference
1  [PMID:27303801]
  Authors
Hicks KA, Ealick SE
  Title
Biochemical and structural characterization of Klebsiella pneumoniae oxamate amidohydrolase in the uric acid degradation pathway.
  Journal
Acta Crystallogr D Struct Biol 72:808-16 (2016)
DOI:10.1107/S2059798316007099
  Sequence
[kpn:KPN_01768]
Other DBs
ExplorEnz - The Enzyme Database: 3.5.1.126
IUBMB Enzyme Nomenclature: 3.5.1.126
ExPASy - ENZYME nomenclature database: 3.5.1.126
BRENDA, the Enzyme Database: 3.5.1.126

KEGG   REACTION: R11617Help
Entry
R11617                      Reaction                               

Name
oxamate amidohydrolase
Definition
Oxamate + H2O <=> Oxalate + Ammonia
Equation
Enzyme
Pathway
rn00230  Purine metabolism
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
Orthology
K22602  oxamate amidohydrolase [EC:3.5.1.126]
Other DBs
RHEA: 51515

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