KEGG   ORTHOLOGY: K22602
Entry
K22602                      KO                                     

Name
hpxW
Definition
oxamate amidohydrolase [EC:3.5.1.126]
Pathway
ko00230  Purine metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    K22602  hpxW; oxamate amidohydrolase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K22602  hpxW; oxamate amidohydrolase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.1  In linear amides
    3.5.1.126  oxamate amidohydrolase
     K22602  hpxW; oxamate amidohydrolase
Peptidases and inhibitors [BR:ko01002]
 Threonine peptidases
  Family T3: gamma-glutamyltransferase family
   K22602  hpxW; oxamate amidohydrolase
Other DBs
RN: R11617
COG: COG0405
Genes
ENL: A3UG_08000
ECLG: EC036_15400
ECLN: ECNIH4_14590
EAU: DI57_10815
EKB: BFV64_08030
ENO: ECENHK_08050
EEC: EcWSU1_01577(ywrD)
ELG: BH714_03980
ERN: BFV67_07630
ECLS: LI67_009105
ECHG: FY206_09245(hpxW)
ESH: C1N69_08115(hpxW)
ENF: AKI40_4038(ggt)
EBG: FAI37_21530(hpxW)
KPN: KPN_01768
KPU: KP1_2816
KPP: A79E_2466
KPR: KPR_2435
KPJ: N559_2533
KPX: PMK1_04107(ywrD)
KPNU: LI86_12615
KPNK: BN49_2857
KVA: Kvar_2544
KPE: KPK_2602
KOX: KOX_16795
KOE: A225_2207
EAE: EAE_19155
EAR: CCG30051
KLW: DA718_17815(hpxW)
REE: electrica_03267(ywrD)
CLAP: NCTC11466_03691(ywrD)
ICP: ICMP_513(ggt)
SBW: TGUWTKB_0820(ggt)
PSTS: E05_03740
YEY: Y11_21711
SPE: Spro_0930
SRL: SOD_c07840(ywrD)
SPLY: Q5A_004175(ywrD)
SMAF: D781_1713
SFJ: SAMEA4384070_0960(ywrD)
SOF: NCTC11214_00572(ywrD)
RAA: Q7S_04405
ECA: ECA3497
PATR: EV46_17315
PATO: GZ59_35110
PCT: PC1_3315
PEC: W5S_3607
DDQ: DDI_3227
EAM: EAMY_0856(ggt3)
EAY: EAM_0868
ETA: ETA_26240(ggt)
EPY: EpC_27490(ggt)
EPR: EPYR_02985(ggt)
EBI: EbC_08570(ggt)
ERJ: EJP617_19850(ggt)
EGE: EM595_0850(ggt2)
PAM: PANA_0858(ggt)
PLF: PANA5342_3449(ggt7)
PAJ: PAJ_0193(ggt)
PVA: Pvag_0252(ggt1)
HHS: HHS_08180(ggt)
PSTW: DSJ_19490
TPTY: NCTC11468_02971(ywrD)
XCA: xcc-b100_0316(ggt1)
XCP: XCR_4221(ggt)
XCV: XCV0314(ggt1)
XAX: XACM_0290(ggt)
XCI: XCAW_00706(ggt)
XFU: XFF4834R_chr02790(ggt1)
XPH: XppCFBP6546_10355(XppCFBP6546P_10355)
PSD: DSC_09835
VCS: MS6_A0607
VCI: O3Y_16153
PMY: Pmen_3832
PSES: PSCI_5245
EMO: DM558_09430(ggt)
PAT: Patl_2054
PEA: PESP_b0383(ggt)
PART: PARC_b0285(ggt)
PAGA: PAGA_b0401(ggt)
MBS: MRBBS_1211(ywrD) MRBBS_2959(ywrD) MRBBS_3820(ywrD)
AMAL: I607_07370
AMAE: I876_07640
AMAO: I634_07760
AMAD: I636_08175
AMAI: I635_08105
AMAG: I533_07635
AMAC: MASE_07260
AAUS: EP12_08165
PIN: Ping_2425
CJA: CJA_0575
TCX: Tcr_1413
AEH: Mlg_2047
GAI: IMCC3135_13465(ywrD_1)
ADI: B5T_03892
TAU: Tola_1957
SVA: SVA_0806
CNC: CNE_1c07960(ggtA)
CPAU: EHF44_25205(ggt)
COX: E0W60_09580(ggt)
BGP: BGL_2c05070(ywrD)
BXB: DR64_6370
PNU: Pnuc_0445
POH: DPM16_07050(ggt)
PLG: NCTC10937_02925(ywrD_4)
CABA: SBC2_57290(ywrD_2)
BPAR: BN117_3811(ggt)
BPA: BPP0885(ggt)
BBH: BN112_2465(ggt)
BBR: BB0978(ggt)
BBM: BN115_0937(ggt)
BBX: BBS798_0952(ggt)
ODI: ODI_R4100
HYB: Q5W_24690
MMS: mma_0601(ggt2) mma_2541(ggt3) mma_2912(ggt5)
HSE: Hsero_3781(ggt)
HRB: Hrubri_3752(ggt)
OFO: BRW83_0666(ywrD)
LCH: Lcho_3809
BBAG: E1O_25000
SLAC: SKTS_29660
DSU: Dsui_0417
BPRC: D521_1842
ABU: Abu_0961(ggt)
AMOL: AMOL_1572(ggt)
HEBR: AEBR_2498(ggt)
ARC: ABLL_1026
DVM: DvMF_3118
DDS: Ddes_2027
DEF: CNY67_01975(ggt)
AVI: Avi_2100(ggt)
AGC: BSY240_10
RTR: RTCIAT899_PC01410(ggt3)
OCA: OCAR_4626(ggt3) OCAR_5746(ggt) OCAR_6970(ggt4)
OCG: OCA5_c11190(ggt3) OCA5_c22620(ggt4) OCA5_c33200(ggt5)
OCO: OCA4_c11190(ggt3) OCA4_c22610(ggt4) OCA4_c32680(ggt5)
BOS: BSY19_42
VGO: GJW-30_1_02477(ywrD_2)
XAU: Xaut_0189
AZC: AZC_4049
MET: M446_4891
MNO: Mnod_1832
MOR: MOC_1083
MAQU: Maq22A_1p37245(ggt)
BBAR: RHAL1_03571(hpxW)
PHL: KKY_2375
PLEO: OHA_2_00015(ywrD)
MMED: Mame_02855(ywrD_1)
HDI: HDIA_4118(ywrD_2)
KVL: KVU_1141(ggt) KVU_PA0258
KRO: BVG79_01383(ggt)
CID: P73_4040
LIT: FPZ52_11590(ggt)
ROT: FIV09_12575(ywrD2)
SMAZ: LH19_05570
SWI: Swit_1433
SPHD: HY78_19400
SPHI: TS85_03595
SSAN: NX02_01490
ALB: AEB_P2954
GOH: B932_0814
GOY: GLS_c13810(ywrD)
GDJ: Gdia_0219
GXY: GLX_26960
GXL: H845_639
KSC: CD178_00376(ywrD)
APK: APA386B_133(ggt)
ASZ: ASN_2432(ggt) ASN_3552(ggt)
SHUM: STHU_48700(ggt_8)
SVC: STVA_48850(ggt_8)
RRF: F11_17005
MAG: amb4309
MGRY: MSR1_29420(ywrD)
MAGX: XM1_0602
MAGN: WV31_11540
TXI: TH3_11380
AFR: AFE_0785(ggt)
ACU: Atc_m029
BSR: I33_3739
BSL: A7A1_1107
BSH: BSU6051_36100(ywrD)
BSUT: BSUB_03843(ywrD)
BSUL: BSUA_03843(ywrD)
BSUS: Q433_19790
BSS: BSUW23_17730(ywrD)
BST: GYO_3966
BSO: BSNT_10254(ywrD)
BSQ: B657_36100(ywrD)
BSX: C663_3505(ywrD)
BLH: BaLi_c38630(ywrD)
BAY: RBAM_033270(ggt)
BAQ: BACAU_3356(ywrD)
BYA: BANAU_3514(ywrD)
BAMP: B938_17095
BAML: BAM5036_3250(ywrD)
BAMA: RBAU_3467(ywrD)
BAMN: BASU_3244(ywrD)
BAMB: BAPNAU_3523(ywrD)
BAMT: AJ82_18795
BAMY: V529_35950(ywrD)
BMP: NG74_03502(ywrD)
BAO: BAMF_3454(ywrD)
BAZ: BAMTA208_18285(ywrD)
BQL: LL3_03753(ywrD)
BXH: BAXH7_03741(ywrD)
BQY: MUS_3967(ywrD)
BAMI: KSO_002435
BAMC: U471_34610
BAMF: U722_17835
BSIA: CWD84_02425(ggt)
BHT: DIC78_12985(ggt)
BCK: BCO26_0887(ywrD)
BJS: MY9_3669
BACP: SB24_12070
BACB: OY17_00305
BACY: QF06_16465
BACL: BS34A_39230(ywrD)
BALM: BsLM_3626
BEO: BEH_17250
BGY: BGLY_4251
BACQ: DOE78_15690(ggt)
BCIR: C2I06_01440(ggt)
BKW: BkAM31D_03225(ywrD_1)
BKO: CKF48_06320(ggt)
LYG: C1N55_01830(ggt)
PASA: BAOM_0857(ggt)
MEKU: HUW50_13025(ggt)
BBE: BBR47_55520(ywrD)
BAGR: BA6348_04535(ggt)
PSAB: PSAB_06740
PRI: PRIO_1618(ywrD)
PDH: B9T62_01970(ggt)
PPSC: EHS13_27385(ggt)
PALB: EJC50_00070(ggt)
COH: EAV92_12860(ggt)
RFA: A3L23_00931(ywrD)
RHS: A3Q41_02422(ywrD)
RRT: 4535765_03820(ywrD_2)
MOO: BWL13_00319(ywrD_1)
GRY: D7I44_07435(ggt)
ACTN: L083_5367
AFS: AFR_16955
CWO: Cwoe_5039
CTHE: Chro_5193
NPH: NP_1844A(ggt)
NMG: Nmag_3026(ggt1)
 » show all
Reference
  Authors
Pope SD, Chen LL, Stewart V
  Title
Purine utilization by Klebsiella oxytoca M5al: genes for ring-oxidizing and -opening enzymes.
  Journal
J Bacteriol 191:1006-17 (2009)
DOI:10.1128/JB.01281-08
  Sequence
[kox:KOX_16795]
Reference
  Authors
Hicks KA, Ealick SE
  Title
Biochemical and structural characterization of Klebsiella pneumoniae oxamate amidohydrolase in the uric acid degradation pathway.
  Journal
Acta Crystallogr D Struct Biol 72:808-16 (2016)
DOI:10.1107/S2059798316007099
  Sequence
[kpn:KPN_01768]

KEGG   ENZYME: 3.5.1.126
Entry
EC 3.5.1.126                Enzyme                                 

Name
oxamate amidohydrolase;
HpxW
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
Sysname
oxamate amidohydrolase
Reaction(IUBMB)
oxamate + H2O = oxalate + NH3 [RN:R11617]
Reaction(KEGG)
R11617
Substrate
oxamate [CPD:C01444];
H2O [CPD:C00001]
Product
oxalate [CPD:C00209];
NH3 [CPD:C00014]
Comment
The enzyme has been characterized from the bacterium Klebsiella pneumoniae.
History
EC 3.5.1.126 created 2017
Pathway
ec00230  Purine metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K22602  oxamate amidohydrolase
Genes
ENL: A3UG_08000
ECLG: EC036_15400
ECLN: ECNIH4_14590
EAU: DI57_10815
EKB: BFV64_08030
ENO: ECENHK_08050
EEC: EcWSU1_01577(ywrD)
ELG: BH714_03980
ERN: BFV67_07630
ECLS: LI67_009105
ECHG: FY206_09245(hpxW)
ESH: C1N69_08115(hpxW)
ENF: AKI40_4038(ggt)
EBG: FAI37_21530(hpxW)
KPN: KPN_01768
KPU: KP1_2816
KPP: A79E_2466
KPR: KPR_2435
KPJ: N559_2533
KPX: PMK1_04107(ywrD)
KPNU: LI86_12615
KPNK: BN49_2857
KVA: Kvar_2544
KPE: KPK_2602
KOX: KOX_16795
KOE: A225_2207
EAE: EAE_19155
EAR: CCG30051
KLW: DA718_17815(hpxW)
REE: electrica_03267(ywrD)
CLAP: NCTC11466_03691(ywrD)
ICP: ICMP_513(ggt)
SBW: TGUWTKB_0820(ggt)
PSTS: E05_03740
YEY: Y11_21711
SPE: Spro_0930
SRL: SOD_c07840(ywrD)
SPLY: Q5A_004175(ywrD)
SMAF: D781_1713
SFJ: SAMEA4384070_0960(ywrD)
SOF: NCTC11214_00572(ywrD)
RAA: Q7S_04405
ECA: ECA3497
PATR: EV46_17315
PATO: GZ59_35110
PCT: PC1_3315
PEC: W5S_3607
DDQ: DDI_3227
EAM: EAMY_0856(ggt3)
EAY: EAM_0868
ETA: ETA_26240(ggt)
EPY: EpC_27490(ggt)
EPR: EPYR_02985(ggt)
EBI: EbC_08570(ggt)
ERJ: EJP617_19850(ggt)
EGE: EM595_0850(ggt2)
PAM: PANA_0858(ggt)
PLF: PANA5342_3449(ggt7)
PAJ: PAJ_0193(ggt)
PVA: Pvag_0252(ggt1)
HHS: HHS_08180(ggt)
PSTW: DSJ_19490
TPTY: NCTC11468_02971(ywrD)
XCA: xcc-b100_0316(ggt1)
XCP: XCR_4221(ggt)
XCV: XCV0314(ggt1)
XAX: XACM_0290(ggt)
XCI: XCAW_00706(ggt)
XFU: XFF4834R_chr02790(ggt1)
XPH: XppCFBP6546_10355(XppCFBP6546P_10355)
PSD: DSC_09835
VCS: MS6_A0607
VCI: O3Y_16153
PMY: Pmen_3832
PSES: PSCI_5245
EMO: DM558_09430(ggt)
PAT: Patl_2054
PEA: PESP_b0383(ggt)
PART: PARC_b0285(ggt)
PAGA: PAGA_b0401(ggt)
MBS: MRBBS_1211(ywrD) MRBBS_2959(ywrD) MRBBS_3820(ywrD)
AMAL: I607_07370
AMAE: I876_07640
AMAO: I634_07760
AMAD: I636_08175
AMAI: I635_08105
AMAG: I533_07635
AMAC: MASE_07260
AAUS: EP12_08165
PIN: Ping_2425
CJA: CJA_0575
TCX: Tcr_1413
AEH: Mlg_2047
GAI: IMCC3135_13465(ywrD_1)
ADI: B5T_03892
TAU: Tola_1957
SVA: SVA_0806
CNC: CNE_1c07960(ggtA)
CPAU: EHF44_25205(ggt)
COX: E0W60_09580(ggt)
BGP: BGL_2c05070(ywrD)
BXB: DR64_6370
PNU: Pnuc_0445
POH: DPM16_07050(ggt)
PLG: NCTC10937_02925(ywrD_4)
CABA: SBC2_57290(ywrD_2)
BPAR: BN117_3811(ggt)
BPA: BPP0885(ggt)
BBH: BN112_2465(ggt)
BBR: BB0978(ggt)
BBM: BN115_0937(ggt)
BBX: BBS798_0952(ggt)
ODI: ODI_R4100
HYB: Q5W_24690
MMS: mma_0601(ggt2) mma_2541(ggt3) mma_2912(ggt5)
HSE: Hsero_3781(ggt)
HRB: Hrubri_3752(ggt)
OFO: BRW83_0666(ywrD)
LCH: Lcho_3809
BBAG: E1O_25000
SLAC: SKTS_29660
DSU: Dsui_0417
BPRC: D521_1842
ABU: Abu_0961(ggt)
AMOL: AMOL_1572(ggt)
HEBR: AEBR_2498(ggt)
ARC: ABLL_1026
DVM: DvMF_3118
DDS: Ddes_2027
DEF: CNY67_01975(ggt)
AVI: Avi_2100(ggt)
AGC: BSY240_10
RTR: RTCIAT899_PC01410(ggt3)
OCA: OCAR_4626(ggt3) OCAR_5746(ggt) OCAR_6970(ggt4)
OCG: OCA5_c11190(ggt3) OCA5_c22620(ggt4) OCA5_c33200(ggt5)
OCO: OCA4_c11190(ggt3) OCA4_c22610(ggt4) OCA4_c32680(ggt5)
BOS: BSY19_42
VGO: GJW-30_1_02477(ywrD_2)
XAU: Xaut_0189
AZC: AZC_4049
MET: M446_4891
MNO: Mnod_1832
MOR: MOC_1083
MAQU: Maq22A_1p37245(ggt)
BBAR: RHAL1_03571(hpxW)
PHL: KKY_2375
PLEO: OHA_2_00015(ywrD)
MMED: Mame_02855(ywrD_1)
HDI: HDIA_4118(ywrD_2)
KVL: KVU_1141(ggt) KVU_PA0258
KRO: BVG79_01383(ggt)
CID: P73_4040
LIT: FPZ52_11590(ggt)
ROT: FIV09_12575(ywrD2)
SMAZ: LH19_05570
SWI: Swit_1433
SPHD: HY78_19400
SPHI: TS85_03595
SSAN: NX02_01490
ALB: AEB_P2954
GOH: B932_0814
GOY: GLS_c13810(ywrD)
GDJ: Gdia_0219
GXY: GLX_26960
GXL: H845_639
KSC: CD178_00376(ywrD)
APK: APA386B_133(ggt)
ASZ: ASN_2432(ggt) ASN_3552(ggt)
SHUM: STHU_48700(ggt_8)
SVC: STVA_48850(ggt_8)
RRF: F11_17005
MAG: amb4309
MGRY: MSR1_29420(ywrD)
MAGX: XM1_0602
MAGN: WV31_11540
TXI: TH3_11380
AFR: AFE_0785(ggt)
ACU: Atc_m029
BSR: I33_3739
BSL: A7A1_1107
BSH: BSU6051_36100(ywrD)
BSUT: BSUB_03843(ywrD)
BSUL: BSUA_03843(ywrD)
BSUS: Q433_19790
BSS: BSUW23_17730(ywrD)
BST: GYO_3966
BSO: BSNT_10254(ywrD)
BSQ: B657_36100(ywrD)
BSX: C663_3505(ywrD)
BLH: BaLi_c38630(ywrD)
BAY: RBAM_033270(ggt)
BAQ: BACAU_3356(ywrD)
BYA: BANAU_3514(ywrD)
BAMP: B938_17095
BAML: BAM5036_3250(ywrD)
BAMA: RBAU_3467(ywrD)
BAMN: BASU_3244(ywrD)
BAMB: BAPNAU_3523(ywrD)
BAMT: AJ82_18795
BAMY: V529_35950(ywrD)
BMP: NG74_03502(ywrD)
BAO: BAMF_3454(ywrD)
BAZ: BAMTA208_18285(ywrD)
BQL: LL3_03753(ywrD)
BXH: BAXH7_03741(ywrD)
BQY: MUS_3967(ywrD)
BAMI: KSO_002435
BAMC: U471_34610
BAMF: U722_17835
BSIA: CWD84_02425(ggt)
BHT: DIC78_12985(ggt)
BCK: BCO26_0887(ywrD)
BJS: MY9_3669
BACP: SB24_12070
BACB: OY17_00305
BACY: QF06_16465
BACL: BS34A_39230(ywrD)
BALM: BsLM_3626
BEO: BEH_17250
BGY: BGLY_4251
BACQ: DOE78_15690(ggt)
BCIR: C2I06_01440(ggt)
BKW: BkAM31D_03225(ywrD_1)
BKO: CKF48_06320(ggt)
LYG: C1N55_01830(ggt)
PASA: BAOM_0857(ggt)
MEKU: HUW50_13025(ggt)
BBE: BBR47_55520(ywrD)
BAGR: BA6348_04535(ggt)
PSAB: PSAB_06740
PRI: PRIO_1618(ywrD)
PDH: B9T62_01970(ggt)
PPSC: EHS13_27385(ggt)
PALB: EJC50_00070(ggt)
COH: EAV92_12860(ggt)
RFA: A3L23_00931(ywrD)
RHS: A3Q41_02422(ywrD)
RRT: 4535765_03820(ywrD_2)
MOO: BWL13_00319(ywrD_1)
GRY: D7I44_07435(ggt)
ACTN: L083_5367
AFS: AFR_16955
CWO: Cwoe_5039
CTHE: Chro_5193
NPH: NP_1844A(ggt)
NMG: Nmag_3026(ggt1)
 » show all
Reference
1  [PMID:27303801]
  Authors
Hicks KA, Ealick SE
  Title
Biochemical and structural characterization of Klebsiella pneumoniae oxamate amidohydrolase in the uric acid degradation pathway.
  Journal
Acta Crystallogr D Struct Biol 72:808-16 (2016)
DOI:10.1107/S2059798316007099
  Sequence
[kpn:KPN_01768]
Other DBs
ExplorEnz - The Enzyme Database: 3.5.1.126
IUBMB Enzyme Nomenclature: 3.5.1.126
ExPASy - ENZYME nomenclature database: 3.5.1.126
BRENDA, the Enzyme Database: 3.5.1.126

KEGG   REACTION: R11617
Entry
R11617                      Reaction                               

Name
oxamate amidohydrolase
Definition
Oxamate + H2O <=> Oxalate + Ammonia
Equation
Enzyme
Pathway
rn00230  Purine metabolism
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
Orthology
K22602  oxamate amidohydrolase [EC:3.5.1.126]
Other DBs
RHEA: 51515

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