KEGG   ORTHOLOGY: K22706
Entry
K22706                      KO                                     

Name
UGT85A19
Definition
(R)-mandelonitrile beta-glucosyltransferase [EC:2.4.1.354]
Pathway
ko00460  Cyanoamino acid metabolism
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00460 Cyanoamino acid metabolism
    K22706  UGT85A19; (R)-mandelonitrile beta-glucosyltransferase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01003 Glycosyltransferases
    K22706  UGT85A19; (R)-mandelonitrile beta-glucosyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.4  Glycosyltransferases
   2.4.1  Hexosyltransferases
    2.4.1.354  (R)-mandelonitrile beta-glucosyltransferase
     K22706  UGT85A19; (R)-mandelonitrile beta-glucosyltransferase
Glycosyltransferases [BR:ko01003]
 Others
  Hydrophobic molecule
   K22706  UGT85A19; (R)-mandelonitrile beta-glucosyltransferase
Other DBs
RN: R10638
CAZy: GT1
Genes
PPER: 18788923
PMUM: 103319663
AG: ABV68925(UGT85A19)

KEGG   ENZYME: 2.4.1.354
Entry
EC 2.4.1.354                Enzyme                                 

Name
(R)-mandelonitrile beta-glucosyltransferase;
UGT85A19 (gene name)
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-alpha-D-glucose:(R)-mandelonitrile beta-D-glucosyltransferase (configuration-inverting)
Reaction(IUBMB)
UDP-alpha-D-glucose + (R)-mandelonitrile = UDP + (R)-prunasin [RN:R10638]
Reaction(KEGG)
R10638
Substrate
UDP-alpha-D-glucose [CPD:C00029];
(R)-mandelonitrile [CPD:C00561]
Product
UDP [CPD:C00015];
(R)-prunasin [CPD:C00844]
Comment
The enzyme, characterized from Prunus dulcis (almond), is involved in the biosynthesis of the cyanogenic glycosides (R)-prunasin and (R)-amygdalin.
History
EC 2.4.1.354 created 2018
Pathway
ec00460  Cyanoamino acid metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K22706  (R)-mandelonitrile beta-glucosyltransferase
Genes
PPER: 18788923
PMUM: 103319663
Reference
1
  Authors
Franks, T. K., Yadollahi, A., Wirthensohn, M. G., Guerin, J. R., Kaiser, B. N., Sedgley, M. and Ford, C. M.
  Title
A seed coat cyanohydrin glucosyltransferase is associated with bitterness in almond (Prunus dulcis) kernels.
  Journal
Funct Plant Biol 35:236-246 (2008)
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.354
IUBMB Enzyme Nomenclature: 2.4.1.354
ExPASy - ENZYME nomenclature database: 2.4.1.354
BRENDA, the Enzyme Database: 2.4.1.354

KEGG   REACTION: R10638
Entry
R10638                      Reaction                               

Name
UDP-D-glucose:(R)-mandelonitrile beta-D-glucosyltransferase
Definition
Mandelonitrile + UDP-glucose <=> Prunasin + UDP
Equation
Reaction class
RC00005  C00015_C00029
RC00397  C00561_C00844
Enzyme
Pathway
rn00460  Cyanoamino acid metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K22706  (R)-mandelonitrile beta-glucosyltransferase [EC:2.4.1.354]
Other DBs
RHEA: 55987

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