KEGG   ORTHOLOGY: K22913
Entry
K22913                      KO                                     

Name
FIG4
Definition
phosphatidylinositol 3,5-bisphosphate 5-phosphatase [EC:3.1.3.-]
Pathway
ko00562  Inositol phosphate metabolism
ko01100  Metabolic pathways
Disease
H00058  Amyotrophic lateral sclerosis (ALS)
H00264  Charcot-Marie-Tooth disease
H00271  Polymicrogyria
H02127  Yunis-Varon syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    K22913  FIG4; phosphatidylinositol 3,5-bisphosphate 5-phosphatase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.-  
     K22913  FIG4; phosphatidylinositol 3,5-bisphosphate 5-phosphatase
Other DBs
RN: R12124
COG: COG5329
GO: 0043813
Genes
HSA: 9896(FIG4)
PTR: 462932(FIG4)
PPS: 100968851(FIG4)
GGO: 101129899(FIG4)
PON: 100462472(FIG4)
NLE: 100605596(FIG4)
MCC: 699914(FIG4)
MCF: 102141152(FIG4)
CSAB: 103240600(FIG4)
RRO: 104664518(FIG4)
RBB: 108540544(FIG4)
CJC: 100397975(FIG4)
SBQ: 101045189(FIG4)
MMU: 103199(Fig4)
MCAL: 110302995(Fig4)
MPAH: 110326347(Fig4)
RNO: 309855(Fig4)
MUN: 110555441(Fig4)
CGE: 100772123(Fig4)
NGI: 103749554(Fig4)
HGL: 101713458(Fig4)
CCAN: 109678751 109700001(Fig4)
OCU: 100350412(FIG4)
TUP: 102488304(FIG4)
CFA: 475023(FIG4)
VVP: 112925167(FIG4)
AML: 100478507(FIG4)
UMR: 103677005(FIG4)
UAH: 113264745(FIG4)
ORO: 101380903(FIG4)
ELK: 111158261
FCA: 101080288(FIG4)
PTG: 102960612(FIG4)
PPAD: 109263531(FIG4)
AJU: 106968895(FIG4)
BTA: 534118(FIG4)
BOM: 102265013(FIG4)
BIU: 109563831(FIG4)
BBUB: 102389963(FIG4)
CHX: 102184062(FIG4)
OAS: 101113245(FIG4)
SSC: 100511669(FIG4)
CFR: 102510940(FIG4)
CDK: 105097108(FIG4)
BACU: 103003729(FIG4)
LVE: 103088226(FIG4)
OOR: 101284291(FIG4)
DLE: 111164526(FIG4)
PCAD: 102975912(FIG4)
ECB: 100066727(FIG4)
EPZ: 103551070(FIG4)
EAI: 106829753(FIG4)
MYB: 102250402(FIG4)
MYD: 102757881(FIG4)
MNA: 107540713(FIG4)
HAI: 109391410(FIG4)
DRO: 112297009(FIG4)
PALE: 102893133(FIG4)
RAY: 107505358 107519380(FIG4)
MJV: 108388110(FIG4)
LAV: 100655691(FIG4)
TMU: 101357781
MDO: 100029200(FIG4)
SHR: 100919694(FIG4)
PCW: 110222905(FIG4)
OAA: 100076962(FIG4)
GGA: 421762(FIG4)
MGP: 100544646
CJO: 107311844(FIG4)
NMEL: 110395426(FIG4)
APLA: 101790079(FIG4)
ACYG: 106032594(FIG4)
TGU: 100229159(FIG4)
LSR: 110483711(FIG4)
SCAN: 103818678(FIG4)
GFR: 102034828(FIG4)
FAB: 101808907(FIG4)
PHI: 102101143(FIG4)
PMAJ: 107201638(FIG4)
CCAE: 111927260(FIG4)
CCW: 104691446(FIG4)
ETL: 114065526(FIG4)
FPG: 101917258(FIG4)
FCH: 102051278(FIG4)
CLV: 102096451(FIG4)
EGZ: 104131561(FIG4)
NNI: 104011125(FIG4)
ACUN: 113477703(FIG4)
PADL: 103918992(FIG4)
AAM: 106489621(FIG4)
ASN: 102369195(FIG4)
AMJ: 102572930(FIG4)
PSS: 102451110
CMY: 102944506(FIG4)
CPIC: 101936855(FIG4)
ACS: 100563516(fig4)
PVT: 110083139(FIG4)
PBI: 103061692(FIG4)
PMUR: 107302944(FIG4)
TSR: 106541495(FIG4)
PMUA: 114594029(FIG4)
GJA: 107124838(FIG4)
XLA: 108716835
XTR: 100379892(fig4)
NPR: 108797970(FIG4)
DRE: 100334605(fig4a)
SRX: 107728106(fig4)
SANH: 107661361(fig4)
SGH: 107556998(fig4)
IPU: 108260131(fig4)
PHYP: 113528695(fig4)
AMEX: 103033692(fig4)
EEE: 113571778(fig4)
TRU: 101062112(fig4)
LCO: 104922019(fig4)
NCC: 104946989(fig4)
MZE: 101466000(fig4)
ONL: 100690388(fig4)
OLA: 101159238(fig4)
XMA: 102217958(fig4)
XCO: 114158832(fig4)
PRET: 103457541(fig4)
CVG: 107086026(fig4)
NFU: 107377621(fig4)
KMR: 108240055(fig4)
ALIM: 106519768(fig4)
CSEM: 103380856(fig4)
POV: 109636003(fig4)
LCF: 108895622(fig4)
SDU: 111216408(fig4)
SLAL: 111650575(fig4)
HCQ: 109518130(fig4)
BPEC: 110166554(fig4)
MALB: 109954226(fig4)
SASA: 106607961(fig4)
OTW: 112217789(fig4)
SALP: 112069281(fig4)
ELS: 105017468(fig4)
SFM: 108921074(fig4)
PKI: 111856637(fig4)
LCM: 102348173(FIG4)
CMK: 103178248(fig4)
RTP: 109939031(fig4)
CIN: 100185300
SPU: 591868
APLC: 110986674
SKO: 102803891
DME: Dmel_CG17840(FIG4)
DER: 6543469
DSE: 6613357
DSI: Dsimw501_GD23291(Dsim_GD23291)
DAN: 6503994
DSR: 110183337
DMN: 108162185
DWI: 6641593
DAZ: 108611915
DNV: 108658830
DHE: 111601145
DVI: 6627308
MDE: 101887510
LCQ: 111680788
AAG: 5571074
AALB: 109408431
AME: 410980
BIM: 100744881
BTER: 100643388
CCAL: 108624176
OBB: 114876073
SOC: 105207539
MPHA: 105836056
AEC: 105146612
ACEP: 105626024
PBAR: 105427459
VEM: 105567857
HST: 105182238
DQU: 106751883
CFO: 105252411
LHU: 105672172
PGC: 109859101
OBO: 105288189
PCF: 106789993
NVI: 100677985
CSOL: 105366105
MDL: 103569970
TCA: 656844
ATD: 109598152
NVL: 108558161
BMOR: 101744751
BMAN: 114246063
PMAC: 106714061
HAW: 110371642
TNL: 113497487
PXY: 105397138
API: 100165350
DNX: 107169587
AGS: 114124812
RMD: 113551677
BTAB: 109037675
CLEC: 106674046
ZNE: 110834904
FCD: 110849489
PVM: 113803095
TUT: 107364863
DPTE: 113789607
CSCU: 111618610
CEL: CELE_C34B7.2(figo-1)
CBR: CBG04077
BMY: Bm1_49675
TSP: Tsp_02057
PCAN: 112566288
CRG: 105326839
MYI: 110447694
OBI: 106877055
LAK: 106170207
EGL: EGR_02441
NVE: 5520403
EPA: 110234633
ADF: 107355581
AMIL: 114954662
PDAM: 113672039
SPIS: 111334062
DGT: 114515941
LJA: Lj3g3v2575920.1(Lj3g3v2575920.1) Lj3g3v2575920.2(Lj3g3v2575920.2) Lj3g3v2575920.3(Lj3g3v2575920.3) Lj3g3v3755430.1(Lj3g3v3755430.1) Lj3g3v3755430.2(Lj3g3v3755430.2) Lj4g3v2215270.1(Lj4g3v2215270.1) Lj6g3v1161810.1(Lj6g3v1161810.1) Lj6g3v1161810.2(Lj6g3v1161810.2)
DOSA: Os02t0782600-01(Os02g0782600) Os03t0182400-01(Os03g0182400) Os06t0195600-01(Os06g0195600) Os06t0355150-00(Os06g0355150) Os08t0109100-01(Os08g0109100)
ATS: 109755546(LOC109755546) 109759556(LOC109759556) 109762738(LOC109762738) 109770619(LOC109770619)
MNG: MNEG_7144
APRO: F751_5947
SCE: YNL325C(FIG4)
ERC: Ecym_2016
KMX: KLMA_20622(FIG4)
NCS: NCAS_0E01310(NCAS0E01310)
NDI: NDAI_0G01480(NDAI0G01480)
TPF: TPHA_0P01540(TPHA0P01540)
TBL: TBLA_0H00170(TBLA0H00170)
TDL: TDEL_0A00330(TDEL0A00330)
KAF: KAFR_0A08580(KAFR0A08580)
CAL: CAALFM_C603040CA(CaO19.5586)
SLB: AWJ20_3660(FIG4)
NCR: NCU08689
NTE: NEUTE1DRAFT145545(NEUTE1DRAFT_145545)
SMP: SMAC_03774(putative fig4)
MGR: MGG_07091
SSCK: SPSK_06883
MAW: MAC_09294
MAJ: MAA_02704
CMT: CCM_00387
BFU: BCIN_12g01640(Bcfig4)
MBE: MBM_00820
ANI: AN7314.2
ANG: ANI_1_300034(An03g02670)
CIM: CIMG_12350(CIMG09460)
ABE: ARB_03255
TVE: TRV_02485
PTE: PTT_17694
ZTR: MYCGRDRAFT_47228(MgFIG4)
CNE: CNE01740
CNB: CNBE1730
ABP: AGABI1DRAFT132740(AGABI1DRAFT_132740)
ABV: AGABI2DRAFT121689(AGABI2DRAFT_121689)
MGL: MGL_2411
MRT: MRET_3237
DFA: DFA_03440
TAN: TA06315
TPV: TP01_0904
BBO: BBOV_IV008690(23.m06179)
SMIN: v1.2.025015.t1(symbB.v1.2.025015.t1)
SPAR: SPRG_13688
 » show all
Reference
  Authors
Rudge SA, Anderson DM, Emr SD
  Title
Vacuole size control: regulation of PtdIns(3,5)P2 levels by the vacuole-associated Vac14-Fig4 complex, a PtdIns(3,5)P2-specific phosphatase.
  Journal
Mol Biol Cell 15:24-36 (2004)
DOI:10.1091/mbc.e03-05-0297
  Sequence
[sce:YNL325C]

KEGG   REACTION: R12124
Entry
R12124                      Reaction                               

Definition
1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O <=> 1-Phosphatidyl-1D-myo-inositol 3-phosphate + Orthophosphate
Equation
Comment
phosphatidylinositol 3,5-bisphosphate 5-phosphatase
Reaction class
RC00078  C04549_C11556
Enzyme
3.1.3.-
Pathway
rn00562  Inositol phosphate metabolism
rn01100  Metabolic pathways
Orthology
K22913  phosphatidylinositol 3,5-bisphosphate 5-phosphatase [EC:3.1.3.-]

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