KEGG   ORTHOLOGY: K23233
Entry
K23233                      KO                                     

Name
ODH1
Definition
D-octopine dehydrogenase [EC:1.5.1.11]
Pathway
ko00330  Arginine and proline metabolism
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00330 Arginine and proline metabolism
    K23233  ODH1; D-octopine dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.11  D-octopine dehydrogenase
     K23233  ODH1; D-octopine dehydrogenase
Other DBs
RN: R00562
GO: 0047830
Genes
MYI: 110451252
AG: CAC36305(ODH1)
Reference
  Authors
Muller A, Janssen F, Grieshaber MK
  Title
Putative reaction mechanism of heterologously expressed octopine dehydrogenase from the great scallop, Pecten maximus (L).
  Journal
FEBS J 274:6329-39 (2007)
DOI:10.1111/j.1742-4658.2007.06151.x
  Sequence

KEGG   ENZYME: 1.5.1.11
Entry
EC 1.5.1.11                 Enzyme                                 

Name
D-octopine dehydrogenase;
D-octopine synthase;
octopine dehydrogenase;
octopine:NAD+ oxidoreductase;
ODH;
2-N-(D-1-carboxyethyl)-L-arginine:NAD+ oxidoreductase (L-arginine-forming)
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
N2-(D-1-carboxyethyl)-L-arginine:NAD+ oxidoreductase (L-arginine-forming)
Reaction(IUBMB)
N2-(D-1-carboxyethyl)-L-arginine + NAD+ + H2O = L-arginine + pyruvate + NADH + H+ [RN:R00562]
Reaction(KEGG)
R00562
Substrate
N2-(D-1-carboxyethyl)-L-arginine [CPD:C04137];
NAD+ [CPD:C00003];
H2O [CPD:C00001]
Product
L-arginine [CPD:C00062];
pyruvate [CPD:C00022];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
In the reverse direction, acts also on L-ornithine, L-lysine and L-histidine.
History
EC 1.5.1.11 created 1972
Pathway
ec00330  Arginine and proline metabolism
Orthology
K23233  D-octopine dehydrogenase
Genes
MYI: 110451252
Reference
1
  Authors
Kemp, J.D., Hack, E., Sutton, D.W. and El-Wakil, M.
  Title
Unusual amino acids and their relationship to tumorigenesis.
  Journal
Proc Int Conf Plant Pathol Bact 4th:183-188 (1979)
Reference
2  [PMID:4310628]
  Authors
van Thoai N, Huc C, Pho DB, Olomucki A.
  Title
[Octopine dehydrogenase. Purification and catalytic properties]
  Journal
Biochim Biophys Acta 191:46-57 (1969)
DOI:10.1016/0005-2744(69)90313-1
Other DBs
ExplorEnz - The Enzyme Database: 1.5.1.11
IUBMB Enzyme Nomenclature: 1.5.1.11
ExPASy - ENZYME nomenclature database: 1.5.1.11
BRENDA, the Enzyme Database: 1.5.1.11
CAS: 37256-27-2

KEGG   REACTION: R00562
Entry
R00562                      Reaction                               

Name
N2-(D-1-carboxyethyl)-L-arginine:NAD+ oxidoreductase (L-arginine-forming)
Definition
D-Octopine + NAD+ + H2O <=> L-Arginine + Pyruvate + NADH + H+
Equation
Reaction class
RC00001  C00003_C00004
RC00283  C00062_C04137
RC00581  C00022_C04137
Enzyme
Pathway
rn00330  Arginine and proline metabolism
Orthology
K23233  D-octopine dehydrogenase [EC:1.5.1.11]
Other DBs
RHEA: 16288

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