KEGG   ORTHOLOGY: K23373
Entry
K23373                      KO                                     

Name
sbnH
Definition
2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate decarboxylase [EC:4.1.1.117]
Pathway
ko00997  Biosynthesis of various secondary metabolites - part 3
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Module
M00875  Staphyloferrin B biosynthesis, L-serine => staphyloferrin B
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00997 Biosynthesis of various secondary metabolites - part 3
    K23373  sbnH; 2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate decarboxylase
Enzymes [BR:ko01000]
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.1  Carboxy-lyases
    4.1.1.117  2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate decarboxylase
     K23373  sbnH; 2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate decarboxylase
Other DBs
RN: R12309
COG: COG0019
Genes
SDN: Sden_0584
PSAL: PSLF89_1986
RSO: RSp0424(ssd)
RSL: RPSI07_mp0385
RSN: RSPO_m01404
RSM: CMR15_mp10437
RSE: F504_3900
RSY: RSUY_34920(btrK)
RPU: CDC45_19750
CNC: CNE_2c14900(lysA)
RME: Rmet_1110(lysA)
NET: Neut_1742
CPEL: CPEL_0305
MNO: Mnod_6954
MAQU: Maq22A_c25460(lysA)
HLI: HLI_03735
SAU: SA0119(sbnH)
SAV: SAV0123
SAW: SAHV_0122
SAM: MW0096(sbnH)
SAS: SAS0097
SAR: SAR0126
SAC: SACOL0107
SAX: USA300HOU_0134(lysA1)
SAE: NWMN_0067(sbnH)
SAD: SAAV_0091
SUU: M013TW_0113(sbnH)
SUE: SAOV_0070
SUJ: SAA6159_00106(sbnH)
SUK: SAA6008_00101(sbnH)
SUC: ECTR2_79
SUZ: MS7_0115
SUW: SATW20_01350(sbnH)
SUG: SAPIG0135
SUF: SARLGA251_00980(sbnH)
SAUA: SAAG_00607
SAUS: SA40_0090(sbnH)
SAUU: SA957_0105(sbnH)
SAUG: SA268_0102(sbnH)
SAUZ: SAZ172_0134(sbnH)
SAUF: X998_0102
SAB: SAB0062
SUY: SA2981_0124(sbnH)
SAUB: C248_0111
SAUM: BN843_1250
SAUC: CA347_134
SAUR: SABB_01717(sbnH)
SAUI: AZ30_00640
SAUD: CH52_05105
SAMS: NI36_00535
SDT: SPSE_2117
SHU: SHYC_00390(sbnH)
SSCH: LH95_00390
SSCZ: RN70_00610
SAGQ: EP23_09735
SDP: NCTC12225_02334(lysA_2)
CCT: CC1_17280
ROB: CK5_31170
ERH: ERH_0207(lysA)
EBM: SG0102_00780(lysA_1)
SHY: SHJG_0926
SALJ: SMD11_0162(lysA)
FAL: FRAAL6420
ASE: ACPL_4370(lysA)
ACTN: L083_3996(lysA)
AFS: AFR_21240
ACTS: ACWT_4241
PFLA: Pflav_024170(sbnH)
PSUU: Psuf_079620(sbnH)
SNA: Snas_3735
LET: O77CONTIG1_03927(btrK)
 » show all
Reference
  Authors
Dale SE, Doherty-Kirby A, Lajoie G, Heinrichs DE
  Title
Role of siderophore biosynthesis in virulence of Staphylococcus aureus: identification and characterization of genes involved in production of a siderophore.
  Journal
Infect Immun 72:29-37 (2004)
DOI:10.1128/IAI.72.1.29-37.2004
  Sequence
[sam:MW0096]
Reference
  Authors
Cheung J, Beasley FC, Liu S, Lajoie GA, Heinrichs DE
  Title
Molecular characterization of staphyloferrin B biosynthesis in Staphylococcus aureus.
  Journal
Mol Microbiol 74:594-608 (2009)
DOI:10.1111/j.1365-2958.2009.06880.x

KEGG   ENZYME: 4.1.1.117
Entry
EC 4.1.1.117                Enzyme                                 

Name
2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate decarboxylase;
sbnH (gene name)
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
Sysname
2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate carboxy-lyase (2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate-forming)
Reaction(IUBMB)
2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate = 2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate + CO2 [RN:R12309]
Reaction(KEGG)
R12309
Substrate
2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate [CPD:C22072]
Product
2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate [CPD:C22073];
CO2 [CPD:C00011]
Comment
The enzyme, characterized from the bacterium Staphylococcus aureus, participates in the biosynthesis of the siderophore staphyloferrin B.
History
EC 4.1.1.117 created 2019
Pathway
ec00997  Biosynthesis of various secondary metabolites - part 3
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K23373  2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate decarboxylase
Genes
SDN: Sden_0584
PSAL: PSLF89_1986
RSO: RSp0424(ssd)
RSL: RPSI07_mp0385
RSN: RSPO_m01404
RSM: CMR15_mp10437
RSE: F504_3900
RSY: RSUY_34920(btrK)
RPU: CDC45_19750
CNC: CNE_2c14900(lysA)
RME: Rmet_1110(lysA)
NET: Neut_1742
CPEL: CPEL_0305
MNO: Mnod_6954
MAQU: Maq22A_c25460(lysA)
HLI: HLI_03735
SAU: SA0119(sbnH)
SAV: SAV0123
SAW: SAHV_0122
SAM: MW0096(sbnH)
SAS: SAS0097
SAR: SAR0126
SAC: SACOL0107
SAX: USA300HOU_0134(lysA1)
SAE: NWMN_0067(sbnH)
SAD: SAAV_0091
SUU: M013TW_0113(sbnH)
SUE: SAOV_0070
SUJ: SAA6159_00106(sbnH)
SUK: SAA6008_00101(sbnH)
SUC: ECTR2_79
SUZ: MS7_0115
SUW: SATW20_01350(sbnH)
SUG: SAPIG0135
SUF: SARLGA251_00980(sbnH)
SAUA: SAAG_00607
SAUS: SA40_0090(sbnH)
SAUU: SA957_0105(sbnH)
SAUG: SA268_0102(sbnH)
SAUZ: SAZ172_0134(sbnH)
SAUF: X998_0102
SAB: SAB0062
SUY: SA2981_0124(sbnH)
SAUB: C248_0111
SAUM: BN843_1250
SAUC: CA347_134
SAUR: SABB_01717(sbnH)
SAUI: AZ30_00640
SAUD: CH52_05105
SAMS: NI36_00535
SDT: SPSE_2117
SHU: SHYC_00390(sbnH)
SSCH: LH95_00390
SSCZ: RN70_00610
SAGQ: EP23_09735
SDP: NCTC12225_02334(lysA_2)
CCT: CC1_17280
ROB: CK5_31170
ERH: ERH_0207(lysA)
EBM: SG0102_00780(lysA_1)
SHY: SHJG_0926
SALJ: SMD11_0162(lysA)
FAL: FRAAL6420
ASE: ACPL_4370(lysA)
ACTN: L083_3996(lysA)
AFS: AFR_21240
ACTS: ACWT_4241
PFLA: Pflav_024170(sbnH)
PSUU: Psuf_079620(sbnH)
SNA: Snas_3735
LET: O77CONTIG1_03927(btrK)
 » show all
Reference
1  [PMID:19775248]
  Authors
Cheung J, Beasley FC, Liu S, Lajoie GA, Heinrichs DE
  Title
Molecular characterization of staphyloferrin B biosynthesis in Staphylococcus aureus.
  Journal
Mol Microbiol 74:594-608 (2009)
DOI:10.1111/j.1365-2958.2009.06880.x
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.117
IUBMB Enzyme Nomenclature: 4.1.1.117
ExPASy - ENZYME nomenclature database: 4.1.1.117
BRENDA, the Enzyme Database: 4.1.1.117

KEGG   REACTION: R12309
Entry
R12309                      Reaction                               

Name
2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate carboxy-lyase (2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate-forming)
Definition
2-[(L-Alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate <=> 2-[(2-Aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate + CO2
Equation
Enzyme
Pathway
rn00997  Biosynthesis of various secondary metabolites - part 3
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00875  Staphyloferrin B biosynthesis, L-serine => staphyloferrin B
Orthology
K23373  2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate decarboxylase [EC:4.1.1.117]

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