KEGG   ORTHOLOGY: K23385
Entry
K23385                      KO                                     

Name
dokD
Definition
D-ornithine/D-lysine decarboxylase [EC:4.1.1.116]
Pathway
ko00310  Lysine degradation
ko00472  D-Arginine and D-ornithine metabolism
ko01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    K23385  dokD; D-ornithine/D-lysine decarboxylase
  09106 Metabolism of other amino acids
   00472 D-Arginine and D-ornithine metabolism
    K23385  dokD; D-ornithine/D-lysine decarboxylase
Enzymes [BR:ko01000]
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.1  Carboxy-lyases
    4.1.1.116  D-ornithine/D-lysine decarboxylase
     K23385  dokD; D-ornithine/D-lysine decarboxylase
Other DBs
RN: R12304 R12305
COG: COG0019
Genes
STY: STY2590
STT: t0504
SEX: STBHUCCB_5420
SENT: TY21A_02565
STM: STM2360
SEO: STM14_2907
SEV: STMMW_23821
SEY: SL1344_2329
SEM: STMDT12_C23820
SEJ: STMUK_2390
SENI: CY43_12630
SPT: SPA0504
SEK: SSPA0468
SEI: SPC_1346
SEC: SCH_2362(dcdA)
SHB: SU5_02955
SENS: Q786_11650
SED: SeD_A2711
SEG: SG2389
SEL: SPUL_0525
SET: SEN2342
SENA: AU38_11845
SENO: AU37_11860
SENV: AU39_11855
SENQ: AU40_13270
SENL: IY59_12180
SEEP: I137_02420
SENE: IA1_11770
MINT: C7M51_04183(lysA_2)
MTHI: C7M52_02873(lysA_2)
ETR: ETAE_3108
ETD: ETAF_2803
ETE: ETEE_1297(lysA)
HPAR: AL518_07035(lysA)
AMAH: DLM_1427
AQS: DKK66_15610(lysA)
BTS: Btus_0317
CNO: NT01CX_2116(lysA)
 » show all
Reference
  Authors
Phillips RS, Poteh P, Miller KA, Hoover TR
  Title
STM2360 encodes a d-ornithine/d-lysine decarboxylase in Salmonella enterica serovar typhimurium.
  Journal
Arch Biochem Biophys 634:83-87 (2017)
DOI:10.1016/j.abb.2017.09.010
  Sequence
[stm:STM2360]

KEGG   ENZYME: 4.1.1.116
Entry
EC 4.1.1.116                Enzyme                                 

Name
D-ornithine/D-lysine decarboxylase;
dokD (gene name);
DOKDC
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
Sysname
D-ornithine/D-lysine carboxy-lyase
Reaction(IUBMB)
(1) D-ornithine = putrescine + CO2 [RN:R12304];
(2) D-lysine = cadaverine + CO2 [RN:R12305]
Reaction(KEGG)
R12304 R12305
Substrate
D-ornithine [CPD:C00515];
D-lysine [CPD:C00739]
Product
putrescine [CPD:C00134];
CO2 [CPD:C00011];
cadaverine [CPD:C01672]
Comment
The enzyme, characterized from the bacterium Salmonella typhimurium LT2, is specific for D-ornithine and D-lysine. Requires pyridoxal 5'-phosphate.
History
EC 4.1.1.116 created 2019
Pathway
ec00310  Lysine degradation
ec00472  D-Arginine and D-ornithine metabolism
ec01100  Metabolic pathways
Orthology
K23385  D-ornithine/D-lysine decarboxylase
Genes
STY: STY2590
STT: t0504
SEX: STBHUCCB_5420
SENT: TY21A_02565
STM: STM2360
SEO: STM14_2907
SEV: STMMW_23821
SEY: SL1344_2329
SEM: STMDT12_C23820
SEJ: STMUK_2390
SENI: CY43_12630
SPT: SPA0504
SEK: SSPA0468
SEI: SPC_1346
SEC: SCH_2362(dcdA)
SHB: SU5_02955
SENS: Q786_11650
SED: SeD_A2711
SEG: SG2389
SEL: SPUL_0525
SET: SEN2342
SENA: AU38_11845
SENO: AU37_11860
SENV: AU39_11855
SENQ: AU40_13270
SENL: IY59_12180
SEEP: I137_02420
SENE: IA1_11770
MINT: C7M51_04183(lysA_2)
MTHI: C7M52_02873(lysA_2)
ETR: ETAE_3108
ETD: ETAF_2803
ETE: ETEE_1297(lysA)
HPAR: AL518_07035(lysA)
AMAH: DLM_1427
AQS: DKK66_15610(lysA)
BTS: Btus_0317
CNO: NT01CX_2116(lysA)
 » show all
Reference
1  [PMID:29024617]
  Authors
Phillips RS, Poteh P, Miller KA, Hoover TR
  Title
STM2360 encodes a d-ornithine/d-lysine decarboxylase in Salmonella enterica serovar typhimurium.
  Journal
Arch Biochem Biophys 634:83-87 (2017)
DOI:10.1016/j.abb.2017.09.010
  Sequence
[stm:STM2360]
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.116
IUBMB Enzyme Nomenclature: 4.1.1.116
ExPASy - ENZYME nomenclature database: 4.1.1.116
BRENDA, the Enzyme Database: 4.1.1.116

KEGG   REACTION: R12304
Entry
R12304                      Reaction                               

Name
D-ornithine carboxy-lyase
Definition
D-Ornithine <=> Putrescine + CO2
Equation
Enzyme
Pathway
rn00472  D-Arginine and D-ornithine metabolism
rn01100  Metabolic pathways
Orthology
K23385  D-ornithine/D-lysine decarboxylase [EC:4.1.1.116]

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