KEGG   ORTHOLOGY: K23447
Entry
K23447                      KO                                     

Name
sfnaB
Definition
staphyloferrin A synthase [EC:6.3.2.57]
Pathway
ko00997  Biosynthesis of various secondary metabolites - part 3
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Module
M00876  Staphyloferrin A biosynthesis, L-ornithine => staphyloferrin A
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00997 Biosynthesis of various secondary metabolites - part 3
    K23447  sfnaB; staphyloferrin A synthase
Enzymes [BR:ko01000]
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.2  Acid-D-amino-acid ligases (peptide synthases)
    6.3.2.57  staphyloferrin A synthase
     K23447  sfnaB; staphyloferrin A synthase
Other DBs
RN: R12354
Genes
LPH: LPV_1432(FrgA)
LPO: LPO_1303(FrgA)
LPU: LPE509_01881
LPM: LP6_1307(frgA)
LPF: lpl1279
LPP: lpp1280
LPC: LPC_0740(frgA)
LPA: lpa_01955
LPE: lp12_1263
LLO: LLO_3129(FrgA)
LHA: LHA_3006(FrgA)
LCD: clem_01380(iucC)
LLG: 44548918_02520(iucC)
RPI: Rpic_0174
HHD: HBHAL_4881(figA)
HLI: HLI_03745
SAU: SA1981
SAV: SAV2179
SAW: SAHV_2163
SAM: MW2105
SAS: SAS2080
SAR: SAR2270
SAC: SACOL2169
SAE: NWMN_2080
SAD: SAAV_2240
SUU: M013TW_2145(sfaB)
SUZ: MS7_2202
SUG: SAPIG2239
SAUA: SAAG_00014
SAUS: SA40_1934
SAUU: SA957_2018
SAUG: SA268_2089
SAUF: X998_2164
SAB: SAB2060c
SAUB: C248_2217
SAUC: CA347_2264
SAUR: SABB_01483
SAUI: AZ30_11520
SAUD: CH52_08050
SAMS: NI36_10760
SER: SERP1779
SEP: SE1770
SEPP: SEB_01779
SEPS: DP17_723
SHA: SH0861
SSP: SSP0707
SCA: SCA_1682
SDT: SPSE_0634
SPAS: STP1_0608
SXO: SXYL_00749(sfaB)
SCAP: AYP1020_1372(iucA)
SSCH: LH95_03230
SSCZ: RN70_03505
SAGQ: EP23_06670
SDP: NCTC12225_00707(iucC_2)
ASE: ACPL_4368
ACTN: L083_3994
ACTS: ACWT_4239
SNA: Snas_3733
 » show all
Reference
  Authors
Cotton JL, Tao J, Balibar CJ
  Title
Identification and characterization of the Staphylococcus aureus gene cluster coding for staphyloferrin A.
  Journal
Biochemistry 48:1025-35 (2009)
DOI:10.1021/bi801844c
  Sequence
[sau:SA1981]

KEGG   ENZYME: 6.3.2.57
Entry
EC 6.3.2.57                 Enzyme                                 

Name
staphyloferrin A synthase;
sfnaB (gene name)
Class
Ligases;
Forming carbon-nitrogen bonds;
Acid-D-amino-acid ligases (peptide synthases)
Sysname
N5-[(S)-citryl]-D-ornithine:citrate ligase (staphyloferrin A-forming)
Reaction(IUBMB)
ATP + N5-[(S)-citryl]-D-ornithine + citrate = AMP + diphosphate + staphyloferrin A [RN:R12354]
Reaction(KEGG)
R12354
Substrate
ATP [CPD:C00002];
N5-[(S)-citryl]-D-ornithine [CPD:C22101];
citrate [CPD:C00158]
Product
AMP [CPD:C00020];
diphosphate [CPD:C00013];
staphyloferrin A [CPD:C22102]
Comment
Requires Mg2+. The enzyme, characterized from the bacterium Staphylococcus aureus, catalyses the last step in the biosynthesis of the siderophore staphyloferrin A. It belongs to a class of siderophore synthases known as type A nonribosomal peptide synthase-independent synthases (NIS). Type A NIS enzymes are responsible for the formation of amide or ester bonds between polyamines or amino alcohols and a prochiral carboxyl group of citrate. The enzyme forms a citrate adenylate intermediate prior to ligation.
History
EC 6.3.2.57 created 2019
Pathway
ec00997  Biosynthesis of various secondary metabolites - part 3
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K23447  staphyloferrin A synthase
Genes
LPH: LPV_1432(FrgA)
LPO: LPO_1303(FrgA)
LPU: LPE509_01881
LPM: LP6_1307(frgA)
LPF: lpl1279
LPP: lpp1280
LPC: LPC_0740(frgA)
LPA: lpa_01955
LPE: lp12_1263
LLO: LLO_3129(FrgA)
LHA: LHA_3006(FrgA)
LCD: clem_01380(iucC)
LLG: 44548918_02520(iucC)
RPI: Rpic_0174
HHD: HBHAL_4881(figA)
HLI: HLI_03745
SAU: SA1981
SAV: SAV2179
SAW: SAHV_2163
SAM: MW2105
SAS: SAS2080
SAR: SAR2270
SAC: SACOL2169
SAE: NWMN_2080
SAD: SAAV_2240
SUU: M013TW_2145(sfaB)
SUZ: MS7_2202
SUG: SAPIG2239
SAUA: SAAG_00014
SAUS: SA40_1934
SAUU: SA957_2018
SAUG: SA268_2089
SAUF: X998_2164
SAB: SAB2060c
SAUB: C248_2217
SAUC: CA347_2264
SAUR: SABB_01483
SAUI: AZ30_11520
SAUD: CH52_08050
SAMS: NI36_10760
SER: SERP1779
SEP: SE1770
SEPP: SEB_01779
SEPS: DP17_723
SHA: SH0861
SSP: SSP0707
SCA: SCA_1682
SDT: SPSE_0634
SPAS: STP1_0608
SXO: SXYL_00749(sfaB)
SCAP: AYP1020_1372(iucA)
SSCH: LH95_03230
SSCZ: RN70_03505
SAGQ: EP23_06670
SDP: NCTC12225_00707(iucC_2)
ASE: ACPL_4368
ACTN: L083_3994
ACTS: ACWT_4239
SNA: Snas_3733
 » show all
Reference
1  [PMID:19138128]
  Authors
Cotton JL, Tao J, Balibar CJ.
  Title
Identification and characterization of the Staphylococcus aureus gene cluster coding for staphyloferrin A.
  Journal
Biochemistry 48:1025-35 (2009)
DOI:10.1021/bi801844c
Other DBs
ExplorEnz - The Enzyme Database: 6.3.2.57
IUBMB Enzyme Nomenclature: 6.3.2.57
ExPASy - ENZYME nomenclature database: 6.3.2.57
BRENDA, the Enzyme Database: 6.3.2.57

KEGG   REACTION: R12354
Entry
R12354                      Reaction                               

Definition
N5-Citryl-D-ornithine + Citrate + ATP <=> Staphyloferrin A + AMP + Diphosphate
Equation
Enzyme
Pathway
rn00997  Biosynthesis of various secondary metabolites - part 3
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00876  Staphyloferrin A biosynthesis, L-ornithine => staphyloferrin A
Orthology
K23447  staphyloferrin A synthase [EC:6.3.2.57]
Other DBs
RHEA: 59143

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