KEGG   ORTHOLOGY: K23888
Entry
K23888            Tight     KO                                     

Name
ROQA
Definition
histidyltryptophyldiketopiperazine synthetase [EC:6.3.2.-]
Pathway
ko00404  Staurosporine biosynthesis
ko01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00404 Staurosporine biosynthesis
    K23888  ROQA; histidyltryptophyldiketopiperazine synthetase
Enzymes [BR:ko01000]
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.2  Acid-D-amino-acid ligases (peptide synthases)
    6.3.2.-  
     K23888  ROQA; histidyltryptophyldiketopiperazine synthetase
Other DBs
RN: R12436
COG: COG1020
Genes
PCS: Pc21g15480
Reference
  Authors
Garcia-Estrada C, Ullan RV, Albillos SM, Fernandez-Bodega MA, Durek P, von Dohren H, Martin JF
  Title
A single cluster of coregulated genes encodes the biosynthesis of the mycotoxins roquefortine C and meleagrin in Penicillium chrysogenum.
  Journal
Chem Biol 18:1499-512 (2011)
DOI:10.1016/j.chembiol.2011.08.012
  Sequence
Reference
  Authors
Ali H, Ries MI, Nijland JG, Lankhorst PP, Hankemeier T, Bovenberg RA, Vreeken RJ, Driessen AJ
  Title
A branched biosynthetic pathway is involved in production of roquefortine and related compounds in Penicillium chrysogenum.
  Journal
PLoS One 8:e65328 (2013)
DOI:10.1371/journal.pone.0065328
  Sequence

KEGG   REACTION: R12436
Entry
R12436                      Reaction                               

Definition
L-Tryptophan + L-Histidine <=> Histidyltryptophyldiketopiperazine
Equation
Comment
unclear reaction
Enzyme
6.3.2.-
Pathway
rn00404  Staurosporine biosynthesis
rn01110  Biosynthesis of secondary metabolites
Orthology
K23888  histidyltryptophyldiketopiperazine synthetase [EC:6.3.2.-]

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