KEGG   ORTHOLOGY: K23892
Entry
K23892            Tight     KO                                     

Name
ROQO
Definition
mycotoxins biosynthesis cytochrome P450 monooxygenase RoqO [EC:1.14.14.-]
Pathway
ko00404  Staurosporine biosynthesis
ko01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00404 Staurosporine biosynthesis
    K23892  ROQO; mycotoxins biosynthesis cytochrome P450 monooxygenase RoqO
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.-  
     K23892  ROQO; mycotoxins biosynthesis cytochrome P450 monooxygenase RoqO
Other DBs
RN: R12442 R12446 R12448
COG: COG2124
Genes
PCS: Pc21g15450
Reference
  Authors
Ali H, Ries MI, Nijland JG, Lankhorst PP, Hankemeier T, Bovenberg RA, Vreeken RJ, Driessen AJ
  Title
A branched biosynthetic pathway is involved in production of roquefortine and related compounds in Penicillium chrysogenum.
  Journal
PLoS One 8:e65328 (2013)
DOI:10.1371/journal.pone.0065328
  Sequence
Reference
  Authors
Ries MI, Ali H, Lankhorst PP, Hankemeier T, Bovenberg RA, Driessen AJ, Vreeken RJ
  Title
Novel key metabolites reveal further branching of the roquefortine/meleagrin biosynthetic pathway.
  Journal
J Biol Chem 288:37289-95 (2013)
DOI:10.1074/jbc.M113.512665
  Sequence

KEGG   REACTION: R12448
Entry
R12448                      Reaction                               

Definition
Roquefortine F + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> Neoxaline + [Oxidized NADPH---hemoprotein reductase] + H2O
Equation
Comment
cytochrome P450 monooxygenase
Reaction class
RC03546  C22171_C22172
Enzyme
1.14.14.-
Pathway
rn00404  Staurosporine biosynthesis
rn01110  Biosynthesis of secondary metabolites
Orthology
K23892  mycotoxins biosynthesis cytochrome P450 monooxygenase RoqO [EC:1.14.14.-]

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