KEGG   ORTHOLOGY: K23992
Entry
K23992                      KO                                     

Name
K23992
Definition
1L-myo-inositol 1-phosphate cytidylyltransferase / CDP-L-myo-inositol myo-inositolphosphotransferase [EC:2.7.7.74 2.7.8.34]
Pathway
ko00562  Inositol phosphate metabolism
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    K23992  K23992; 1L-myo-inositol 1-phosphate cytidylyltransferase / CDP-L-myo-inositol myo-inositolphosphotransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.7  Nucleotidyltransferases
    2.7.7.74  1L-myo-inositol 1-phosphate cytidylyltransferase
     K23992  K23992; 1L-myo-inositol 1-phosphate cytidylyltransferase / CDP-L-myo-inositol myo-inositolphosphotransferase
   2.7.8  Transferases for other substituted phosphate groups
    2.7.8.34  CDP-L-myo-inositol myo-inositolphosphotransferase
     K23992  K23992; 1L-myo-inositol 1-phosphate cytidylyltransferase / CDP-L-myo-inositol myo-inositolphosphotransferase
Other DBs
RN: R09669 R09670
COG: COG1213 COG0558
Genes
MTHD: A3224_07290
ENM: EBS_0412
CCRO: CMC5_075830
DAO: Desac_2272
SFU: Sfum_2920 Sfum_2923
BSED: DN745_05540
NAR: Saro_0100
NOR: FA702_11455
SMIC: SmB9_25590
ERY: CP97_03755
TMR: Tmar_0126
RXY: Rxyl_1212
TTR: Tter_0472
AAE: aq_1367(spsI)
TTK: TST_0884
NDE: NIDE0736
NJA: NSJP_1717
MOX: DAMO_2608
AFU: AF_0263
GAC: GACE_2065
GAH: GAH_01161
PFU: PF1058
PFI: PFC_04525
PHO: PH1219(PH1219)
PAB: PAB2433
PYN: PNA2_1704
PYS: Py04_1010
TKO: TK2279
TON: TON_1248
TGA: TGAM_1853
TSI: TSIB_1010
THE: GQS_09430
THA: TAM4_5
THM: CL1_1475
TLT: OCC_08385
THS: TES1_1181
TNU: BD01_1626
TEU: TEU_00190
PPAC: PAP_05835
IAG: Igag_0487
TPE: Tpen_1251
KCR: Kcr_0184
 » show all
Reference
  Authors
Rodrigues MV, Borges N, Henriques M, Lamosa P, Ventura R, Fernandes C, Empadinhas N, Maycock C, da Costa MS, Santos H
  Title
Bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase, the key enzyme for di-myo-inositol-phosphate synthesis in several (hyper)thermophiles.
  Journal
J Bacteriol 189:5405-12 (2007)
DOI:10.1128/JB.00465-07
  Sequence
[rxy:Rxyl_1212]

KEGG   ORTHOLOGY: K07281
Entry
K07281                      KO                                     

Name
ipct
Definition
1L-myo-inositol 1-phosphate cytidylyltransferase [EC:2.7.7.74]
Pathway
ko00562  Inositol phosphate metabolism
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    K07281  ipct; 1L-myo-inositol 1-phosphate cytidylyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.7  Nucleotidyltransferases
    2.7.7.74  1L-myo-inositol 1-phosphate cytidylyltransferase
     K07281  ipct; 1L-myo-inositol 1-phosphate cytidylyltransferase
Other DBs
RN: R09669
COG: COG1213
Genes
CCRO: CMC5_034520
BSED: DN745_10835
NAR: Saro_0102
NOT: C7W88_05615
NOR: FA702_11445
NGF: FRF71_04960
NOG: GKE62_14325
STAX: MC45_06680
SNJ: A7E77_02155
SMY: BJP26_11175
SMIC: SmB9_25610
GDI: GDI0629(hasC)
GDJ: Gdia_1377
RMR: Rmar_1196
CACI: CLOAM0421
TMW: THMA_1449
TMQ: THMB_1449
TMX: THMC_1449
TPT: Tpet_1374
TRQ: TRQ2_1312
TNA: CTN_1074
TNP: Tnap_1392
CABY: Cabys_1832
ACJ: ACAM_0951
HBU: Hbut_0150
TPE: Tpen_1250
BARC: AOA65_0707
 » show all
Reference
  Authors
Rodionov DA, Kurnasov OV, Stec B, Wang Y, Roberts MF, Osterman AL
  Title
Genomic identification and in vitro reconstitution of a complete biosynthetic pathway for the osmolyte di-myo-inositol-phosphate.
  Journal
Proc Natl Acad Sci U S A 104:4279-84 (2007)
DOI:10.1073/pnas.0609279104

KEGG   ENZYME: 2.7.7.74
Entry
EC 2.7.7.74                 Enzyme                                 

Name
1L-myo-inositol 1-phosphate cytidylyltransferase;
CTP:inositol-1-phosphate cytidylyltransferase (bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase (IPCT/DIPPS));
IPCT (bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase (IPCT/DIPPS));
L-myo-inositol-1-phosphate cytidylyltransferase
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
Sysname
CTP:1L-myo-inositol 1-phosphate cytidylyltransferase
Reaction(IUBMB)
CTP + 1L-myo-inositol 1-phosphate = diphosphate + CDP-1L-myo-inositol [RN:R09669]
Reaction(KEGG)
R09669
Substrate
CTP [CPD:C00063];
1L-myo-inositol 1-phosphate [CPD:C04006]
Product
diphosphate [CPD:C00013];
CDP-1L-myo-inositol [CPD:C19794]
Comment
In many organisms this activity is catalysed by a bifunctional enzyme. The cytidylyltransferase domain of the bifunctional EC 2.7.7.74/EC 2.7.8.34 (CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase) is absolutely specific for CTP and 1L-myo-inositol 1-phosphate. The enzyme is involved in biosynthesis of bis(1L-myo-inositol) 1,3'-phosphate, a widespread organic solute in microorganisms adapted to hot environments.
History
EC 2.7.7.74 created 2011
Pathway
ec00562  Inositol phosphate metabolism
Orthology
K07281  1L-myo-inositol 1-phosphate cytidylyltransferase
K23992  1L-myo-inositol 1-phosphate cytidylyltransferase / CDP-L-myo-inositol myo-inositolphosphotransferase
Genes
MTHD: A3224_07290
ENM: EBS_0412
CCRO: CMC5_034520 CMC5_075830
DAO: Desac_2272
SFU: Sfum_2920 Sfum_2923
BSED: DN745_05540 DN745_10835
NAR: Saro_0100 Saro_0102
NOT: C7W88_05615
NOR: FA702_11445 FA702_11455
NGF: FRF71_04960
STAX: MC45_06680
GDI: GDI0629(hasC)
GDJ: Gdia_1377
TMR: Tmar_0126
RXY: Rxyl_1212
TTR: Tter_0472
RMR: Rmar_1196
CACI: CLOAM0421
AAE: aq_1367(spsI)
TTK: TST_0884
TMW: THMA_1449
TMQ: THMB_1449
TMX: THMC_1449
TPT: Tpet_1374
TRQ: TRQ2_1312
TNA: CTN_1074
TNP: Tnap_1392
CABY: Cabys_1832
NDE: NIDE0736
NJA: NSJP_1717
MOX: DAMO_2608
AFU: AF_0263
GAC: GACE_2065
GAH: GAH_01161
PFU: PF1058
PFI: PFC_04525
PHO: PH1219(PH1219)
PAB: PAB2433
PYN: PNA2_1704
PYS: Py04_1010
TKO: TK2279
TON: TON_1248
TGA: TGAM_1853
TSI: TSIB_1010
THE: GQS_09430
THA: TAM4_5
THM: CL1_1475
TLT: OCC_08385
THS: TES1_1181
TNU: BD01_1626
TEU: TEU_00190
PPAC: PAP_05835
ACJ: ACAM_0951
IAG: Igag_0487
HBU: Hbut_0150
KCR: Kcr_0184
BARC: AOA65_0707
 » show all
Reference
1  [PMID:17526717]
  Authors
Rodrigues MV, Borges N, Henriques M, Lamosa P, Ventura R, Fernandes C, Empadinhas N, Maycock C, da Costa MS, Santos H
  Title
Bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase, the key enzyme for di-myo-inositol-phosphate synthesis in several (hyper)thermophiles.
  Journal
J Bacteriol 189:5405-12 (2007)
DOI:10.1128/JB.00465-07
  Sequence
[aae:aq_1367] [afu:AF_0263] [pfu:PF1058][rxy:Rxyl_1212] [tko:TK2279]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.7.74
IUBMB Enzyme Nomenclature: 2.7.7.74
ExPASy - ENZYME nomenclature database: 2.7.7.74
BRENDA, the Enzyme Database: 2.7.7.74

KEGG   REACTION: R09669
Entry
R09669                      Reaction                               

Name
CTP:1L-myo-inositol 1-phosphate cytidylyltransferase
Definition
CTP + 1D-myo-Inositol 3-phosphate <=> Diphosphate + CDP-1L-myo-inositol
Equation
Reaction class
RC00002  C04006_C19794
Enzyme
Pathway
rn00562  Inositol phosphate metabolism
Orthology
K07281  1L-myo-inositol 1-phosphate cytidylyltransferase [EC:2.7.7.74]
K23992  1L-myo-inositol 1-phosphate cytidylyltransferase / CDP-L-myo-inositol myo-inositolphosphotransferase [EC:2.7.7.74 2.7.8.34]
Other DBs
RHEA: 30650

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