PMID:21256798

Hibi Y, Asai K, Arafuka H, Hamajima M, Iwama T, Kawai K

Molecular structure of La3+-induced methanol dehydrogenase-like protein in Methylobacterium radiotolerans.

J Biosci Bioeng 111:547-9 (2011)
DOI:10.1016/j.jbiosc.2010.12.017

[mrd:Mrad2831_0508]

Oxidoreductases;
Acting on the CH-OH group of donors;
With a cytochrome as acceptor
BRITE hierarchy

methanol:cytochrome cL oxidoreductase

methanol + 2 oxidized cytochrome cL = formaldehyde + 2 reduced cytochrome cL [RN:R01146]

R01146
Reaction

methanol [CPD:C00132];
oxidized cytochrome cL [CPD:C18233]

Isolated from the bacterium Methylacidiphilum fumariolicum and many Methylobacterium species. Requires La3+, Ce3+, Pr3+ or Nd3+. The higher lanthanides show decreasing activity with Sm3+, Eu3+ and Gd3+. The lanthanide is coordinated by the enzyme and pyrroloquinoline quinone. Shows little activity with Ca2+, the required cofactor of EC 1.1.2.7, methanol dehydrogenase (cytochrome c).

EC 1.1.2.10 created 2019

1  [PMID:21256798]

Hibi Y, Asai K, Arafuka H, Hamajima M, Iwama T, Kawai K

Molecular structure of La3+-induced methanol dehydrogenase-like protein in Methylobacterium radiotolerans.

J Biosci Bioeng 111:547-9 (2011)
DOI:10.1016/j.jbiosc.2010.12.017

[mrd:Mrad2831_0508]

2  [PMID:23209751]

Nakagawa T, Mitsui R, Tani A, Sasa K, Tashiro S, Iwama T, Hayakawa T, Kawai K

A catalytic role of XoxF1 as La3+-dependent methanol dehydrogenase in Methylobacterium extorquens strain AM1.

PLoS One 7:e50480 (2012)
DOI:10.1371/journal.pone.0050480

3  [PMID:24034209]

Pol A, Barends TR, Dietl A, Khadem AF, Eygensteyn J, Jetten MS, Op den Camp HJ

Rare earth metals are essential for methanotrophic life in volcanic mudpots.

Environ Microbiol 16:255-64 (2014)
DOI:10.1111/1462-2920.12249

4  [PMID:25421364]

Bogart JA, Lewis AJ, Schelter EJ

DFT study of the active site of the XoxF-type natural, cerium-dependent methanol  dehydrogenase enzyme.

Chemistry 21:1743-8 (2015)
DOI:10.1002/chem.201405159

5  [PMID:28488399]

Prejano M, Marino T, Russo N

How Can Methanol Dehydrogenase from Methylacidiphilum fumariolicum Work with the  Alien Ce(III) Ion in the Active Center? A Theoretical Study.

Chemistry 23:8652-8657 (2017)
DOI:10.1002/chem.201700381

6  [PMID:29404411]

Masuda S, Suzuki Y, Fujitani Y, Mitsui R, Nakagawa T, Shintani M, Tani A.

Lanthanide-Dependent Regulation of Methylotrophy in Methylobacteriumaquaticum Strain 22A.

mSphere 3:e00462-17 (2018)
DOI:10.1128/mSphere.00462-17