KEGG   ORTHOLOGY: K23996
Entry
K23996            Tight     KO                                     

Name
phnY
Definition
methylphosphonate hydroxylase [EC:1.14.11.71]
Pathway
ko00440  Phosphonate and phosphinate metabolism
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00440 Phosphonate and phosphinate metabolism
    K23996  phnY; methylphosphonate hydroxylase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.11  With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
    1.14.11.71  methylphosphonate hydroxylase
     K23996  phnY; methylphosphonate hydroxylase
Other DBs
RN: R12452
Genes
GMR: GmarT_03190
Reference
  Authors
Gama SR, Vogt M, Kalina T, Hupp K, Hammerschmidt F, Pallitsch K, Zechel DL
  Title
An Oxidative Pathway for Microbial Utilization of Methylphosphonic Acid as a Phosphate Source.
  Journal
ACS Chem Biol 14:735-741 (2019)
DOI:10.1021/acschembio.9b00024
  Sequence

KEGG   ENZYME: 1.14.11.71
Entry
EC 1.14.11.71               Enzyme                                 

Name
methylphosphonate hydroxylase;
phnY* (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
Sysname
methylphosphonate,2-oxoglutarate:oxygen oxidoreductase (1-hydroxylating)
Reaction(IUBMB)
methylphosphonate + 2-oxoglutarate + O2 = hydroxymethylphosphonate + succinate + CO2 [RN:R12452]
Reaction(KEGG)
R12452
Substrate
methylphosphonate [CPD:C20396];
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007]
Product
hydroxymethylphosphonate [CPD:C06455];
succinate [CPD:C00042];
CO2 [CPD:C00011]
Comment
Requires Fe(II). The enzyme, characterized from the marine bacterium Gimesia maris, participates in a methylphosphonate degradation pathway.
History
EC 1.14.11.71 created 2019
Pathway
ec00440  Phosphonate and phosphinate metabolism
Orthology
K23996  methylphosphonate hydroxylase
Genes
GMR: GmarT_03190
Reference
1  [PMID:30810303]
  Authors
Gama SR, Vogt M, Kalina T, Hupp K, Hammerschmidt F, Pallitsch K, Zechel DL
  Title
An Oxidative Pathway for Microbial Utilization of Methylphosphonic Acid as a Phosphate Source.
  Journal
ACS Chem Biol 14:735-741 (2019)
DOI:10.1021/acschembio.9b00024
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.14.11.71
IUBMB Enzyme Nomenclature: 1.14.11.71
ExPASy - ENZYME nomenclature database: 1.14.11.71
BRENDA, the Enzyme Database: 1.14.11.71

KEGG   REACTION: R12452
Entry
R12452                      Reaction                               

Name
methylphosphonate,2-oxoglutarate:oxygen oxidoreductase (1-hydroxylating)
Definition
Methylphosphonate + 2-Oxoglutarate + Oxygen <=> Hydroxymethylphosphonate + Succinate + CO2
Equation
Reaction class
RC03551  C06455_C20396
Enzyme
Pathway
rn00440  Phosphonate and phosphinate metabolism
Orthology
K23996  methylphosphonate hydroxylase [EC:1.14.11.71]
Other DBs
RHEA: 60119

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