KEGG   ORTHOLOGY: K24856
Entry
K24856                      KO                                     

Name
AFLM
Definition
NADPH-dependent reductase
Pathway
ko00254  Aflatoxin biosynthesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Module
M00937  Aflatoxin biosynthesis, malonyl-CoA => aflatoxin B1
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00254 Aflatoxin biosynthesis
    K24856  AFLM; NADPH-dependent reductase
Other DBs
RN: R10480 R10481
COG: COG1028
Genes
PAN: PODANSg8553
ANI: AN7806.2
AOR: AO090026000019
AFV: AFLA_139300
Reference
PMID:1339261
  Authors
Skory CD, Chang PK, Cary J, Linz JE
  Title
Isolation and characterization of a gene from Aspergillus parasiticus associated with the conversion of versicolorin A to sterigmatocystin in aflatoxin biosynthesis.
  Journal
Appl Environ Microbiol 58:3527-37 (1992)
DOI:10.1128/AEM.58.11.3527-3537.1992
  Sequence

KEGG   ORTHOLOGY: K24438
Entry
K24438                      KO                                     

Name
AFLN, STCS, CYP59A1
Definition
sterigmatocystin biosynthesis cytochrome P450 monooxygenase
Pathway
ko00254  Aflatoxin biosynthesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Module
M00937  Aflatoxin biosynthesis, malonyl-CoA => aflatoxin B1
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00254 Aflatoxin biosynthesis
    K24438  AFLN, STCS, CYP59A1; sterigmatocystin biosynthesis cytochrome P450 monooxygenase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K24438  AFLN, STCS, CYP59A1; sterigmatocystin biosynthesis cytochrome P450 monooxygenase
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, fungi type
  CYP59 family
   K24438  AFLN, STCS, CYP59A1; sterigmatocystin biosynthesis cytochrome P450 monooxygenase
Other DBs
RN: R10480 R10481
COG: COG2124
Genes
PAN: PODANSg8555
ANI: AN7808.2
AOR: AO090026000020
AFV: AFLA_139280
Reference
PMID:7486998
  Authors
Keller NP, Segner S, Bhatnagar D, Adams TH
  Title
stcS, a putative P-450 monooxygenase, is required for the conversion of versicolorin A to sterigmatocystin in Aspergillus nidulans.
  Journal
Appl Environ Microbiol 61:3628-32 (1995)
DOI:10.1128/AEM.61.10.3628-3632.1995
  Sequence
[ani:AN7808.2]
Reference
  Authors
Kelly DE, Krasevec N, Mullins J, Nelson DR
  Title
The CYPome (Cytochrome P450 complement) of Aspergillus nidulans.
  Journal
Fungal Genet Biol 46 Suppl 1:S53-61 (2009)
DOI:10.1016/j.fgb.2008.08.010

KEGG   ORTHOLOGY: K24857
Entry
K24857                      KO                                     

Name
AFLX
Definition
oxidoreductase AflX
Pathway
ko00254  Aflatoxin biosynthesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Module
M00937  Aflatoxin biosynthesis, malonyl-CoA => aflatoxin B1
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00254 Aflatoxin biosynthesis
    K24857  AFLX; oxidoreductase AflX
Other DBs
RN: R10480 R10481
Genes
PAN: PODANSg8573
ANI: AN7810.2
AFV: AFLA_139160
Reference
  Authors
Cary JW, Ehrlich KC, Bland JM, Montalbano BG.
  Title
The aflatoxin biosynthesis cluster gene, aflX, encodes an oxidoreductase involved in conversion of versicolorin A to demethylsterigmatocystin.
  Journal
Appl Environ Microbiol 72:1096-101 (2006)
DOI:10.1128/AEM.72.2.1096-1101.2006
  Sequence

KEGG   ORTHOLOGY: K24858
Entry
K24858                      KO                                     

Name
AFLY
Definition
oxidoreductase AflY
Pathway
ko00254  Aflatoxin biosynthesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Module
M00937  Aflatoxin biosynthesis, malonyl-CoA => aflatoxin B1
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00254 Aflatoxin biosynthesis
    K24858  AFLY; oxidoreductase AflY
Other DBs
RN: R10480 R10481
Genes
PAN: PODANSg8574
ANI: AN7809.2
AOR: AO090026000031
AFV: AFLA_139150
TRG: TRUGW13939_07449
Reference
  Authors
Ehrlich KC, Montalbano B, Boue SM, Bhatnagar D
  Title
An aflatoxin biosynthesis cluster gene encodes a novel oxidase required for conversion of versicolorin a to sterigmatocystin.
  Journal
Appl Environ Microbiol 71:8963-5 (2005)
DOI:10.1128/AEM.71.12.8963-8965.2005
  Sequence

KEGG   REACTION: R10481
Entry
R10481                      Reaction                               

Definition
Versicolorin A <=> 6-Demethylsterigmatocystin
Equation
Comment
multi-step reaction
Reaction class
RC03160  C03683_C20583
Pathway
rn00254  Aflatoxin biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00937  Aflatoxin biosynthesis, malonyl-CoA => aflatoxin B1
Orthology
K24438  sterigmatocystin biosynthesis cytochrome P450 monooxygenase
K24856  NADPH-dependent reductase
K24857  oxidoreductase AflX
K24858  oxidoreductase AflY

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