KEGG   ORTHOLOGY: K15680Help
Entry
K15680                      KO                                     

Name
HSD11B1
Definition
corticosteroid 11-beta-dehydrogenase isozyme 1 [EC:1.1.1.146]
Pathway
ko00140  Steroid hormone biosynthesis
ko00980  Metabolism of xenobiotics by cytochrome P450
ko01100  Metabolic pathways
ko05204  Chemical carcinogenesis
Module
M00109  C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone
Disease
H01111  Cortisone reductase deficiency
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K15680  HSD11B1; corticosteroid 11-beta-dehydrogenase isozyme 1
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    K15680  HSD11B1; corticosteroid 11-beta-dehydrogenase isozyme 1
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis
    K15680  HSD11B1; corticosteroid 11-beta-dehydrogenase isozyme 1
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.146  11beta-hydroxysteroid dehydrogenase
     K15680  HSD11B1; corticosteroid 11-beta-dehydrogenase isozyme 1
BRITE hierarchy
Other DBs
RN: R02836 R03848 R04758 R04840 R09420
GO: 0070524
Genes
HSA: 3290(HSD11B1)
PTR: 457698(HSD11B1)
PPS: 100981291(HSD11B1)
GGO: 101147766(HSD11B1)
PON: 100453076(HSD11B1)
NLE: 100593811(HSD11B1)
MCC: 574322(HSD11B1)
MCF: 101867467(HSD11B1)
CSAB: 103230154(HSD11B1)
RRO: 104664165(HSD11B1)
RBB: 108539553(HSD11B1)
CJC: 100401212(HSD11B1)
SBQ: 101040472(HSD11B1)
MMU: 15483(Hsd11b1)
MCAL: 110305040(Hsd11b1)
MPAH: 110322100(Hsd11b1)
RNO: 25116(Hsd11b1)
MUN: 110553509(Hsd11b1)
CGE: 100762502(Hsd11b1)
NGI: 103727028(Hsd11b1)
HGL: 101716800(Hsd11b1)
CCAN: 109681612(Hsd11b1)
OCU: 100342395(HSD11B1)
TUP: 102502602(HSD11B1)
CFA: 449023(HSD11B1)
VVP: 112907163(HSD11B1)
AML: 100466840(HSD11B1)
UMR: 103672488(HSD11B1)
UAH: 113262645(HSD11B1)
ORO: 101369340(HSD11B1)
ELK: 111162366
FCA: 100529248(HSD11B1)
PTG: 102967279(HSD11B1)
PPAD: 109255094(HSD11B1)
AJU: 106981789(HSD11B1)
BTA: 282589(HSD11B1)
BOM: 102275244(HSD11B1)
BIU: 109570467(HSD11B1)
BBUB: 102409054(HSD11B1)
CHX: 102168375(HSD11B1)
OAS: 443409(HSD11B1)
SSC: 397480(HSD11B1)
CFR: 102503994(HSD11B1)
CDK: 105099329(HSD11B1)
BACU: 103004239(HSD11B1)
LVE: 103086619(HSD11B1)
OOR: 101284098(HSD11B1)
DLE: 111184723(HSD11B1)
PCAD: 102992666(HSD11B1)
ECB: 100056429(HSD11B1)
EPZ: 103548673(HSD11B1)
EAI: 106827175(HSD11B1)
MYB: 102260050(HSD11B1)
MYD: 102771648(HSD11B1)
MNA: 107532934(HSD11B1)
DRO: 112297497(HSD11B1)
PALE: 102882377(HSD11B1)
RAY: 107517624(HSD11B1)
MJV: 108396749(HSD11B1)
LAV: 100667019(HSD11B1)
TMU: 101361858
SHR: 100923255(HSD11B1)
PCW: 110222669(HSD11B1)
OAA: 100079059(HSD11B1)
GGA: 419861(HSD11B1b) 771930(HSD11B1a)
MGP: 100550364(HSD11B1) 100550517
NMEL: 110388207 110388337(HSD11B1)
APLA: 101803228(HSD11B1) 101804020
PMAJ: 107214842 107214843(HSD11B1)
CCAE: 111922428 111939805(HSD11B1)
ETL: 114063124(HSD11B1) 114063139
FCH: 102051959 102053319(HSD11B1)
CLV: 102086357(HSD11B1) 102090135
AMJ: 102559578 102568341(HSD11B1)
ACS: 100555338(hsd11b1) 100555943
PVT: 110072366(HSD11B1) 110081926
PBI: 103052790 103059600(HSD11B1)
PMUR: 107292272(HSD11B1) 107301624 107301720
TSR: 106539582(HSD11B1)
PMUA: 114586681 114587149 114599353(HSD11B1)
GJA: 107126071(HSD11B1) 107126084
XLA: 108709376(hsd11b1.S) 379494(hsd11b1l.2.L) 379497(hsd11b1.L) 399012(hsd11b1l.L)
XTR: 100038278(hsd11b1l.2) 100489345(hsd11b1)
NPR: 108789677(HSD11B1) 108800094
DRE: 100333777(hsd11b1lb)
SRX: 107750927
CCAR: 109048452
LCM: 102345616(HSD11B1)
CMK: 103182506(hsd11b1)
SPU: 764876
PCAN: 112558142
CRG: 105339932
OBI: 106874424
EPA: 110252440
ADF: 107340777
PDAM: 113664253
SPIS: 111336520
AQU: 100631443
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2808402
  Authors
Agarwal AK, Monder C, Eckstein B, White PC
  Title
Cloning and expression of rat cDNA encoding corticosteroid 11 beta-dehydrogenase.
  Journal
J Biol Chem 264:18939-43 (1989)
  Sequence
[rno:25116]
Reference
  Authors
Tomlinson JW, Walker EA, Bujalska IJ, Draper N, Lavery GG, Cooper MS, Hewison M, Stewart PM
  Title
11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response.
  Journal
Endocr Rev 25:831-66 (2004)
DOI:10.1210/er.2003-0031

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