KEGG ORTHOLOGY: K15680

ORTHOLOGY: K15680

Entry

K15680 KO

Name

HSD11B1

Definition

corticosteroid 11-beta-dehydrogenase isozyme 1 [EC:1.1.1.146]

Pathway

ko00140

Steroid hormone biosynthesis

ko00980

Metabolism of xenobiotics by cytochrome P450

ko01100

Metabolic pathways

ko05204

Chemical carcinogenesis

Module

M00109

C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone

Disease

H01111

Cortisone reductase deficiency

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K15680  HSD11B1; corticosteroid 11-beta-dehydrogenase isozyme 1
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    K15680  HSD11B1; corticosteroid 11-beta-dehydrogenase isozyme 1
09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis
    K15680  HSD11B1; corticosteroid 11-beta-dehydrogenase isozyme 1
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.146  11beta-hydroxysteroid dehydrogenase
     K15680  HSD11B1; corticosteroid 11-beta-dehydrogenase isozyme 1

Other DBs

RN:	R02836 R03848 R04758 R04840 R09420

GO:

0070524

Genes

HSA:	3290(HSD11B1)

PTR:	457698(HSD11B1)

PPS:	100981291(HSD11B1)

GGO:	101147766(HSD11B1)

PON:	100453076(HSD11B1)

NLE:	100593811(HSD11B1)

MCC:	574322(HSD11B1)

MCF:	101867467(HSD11B1)

CSAB:

103230154(HSD11B1)

RRO:	104664165(HSD11B1)

RBB:	108539553(HSD11B1)

CJC:	100401212(HSD11B1)

SBQ:	101040472(HSD11B1)

MMU:	15483(Hsd11b1)

MCAL:

110305040(Hsd11b1)

MPAH:

110322100(Hsd11b1)

RNO:	25116(Hsd11b1)

MUN:	110553509(Hsd11b1)

CGE:	100762502(Hsd11b1)

NGI:	103727028(Hsd11b1)

HGL:	101716800(Hsd11b1)

CCAN:

109681612(Hsd11b1)

OCU:	100342395(HSD11B1)

TUP:	102502602(HSD11B1)

CFA:	449023(HSD11B1)

VVP:	112907163(HSD11B1)

AML:	100466840(HSD11B1)

UMR:	103672488(HSD11B1)

UAH:	113262645(HSD11B1)

ORO:	101369340(HSD11B1)

ELK:

111162366

FCA:	100529248(HSD11B1)

PTG:	102967279(HSD11B1)

PPAD:

109255094(HSD11B1)

AJU:	106981789(HSD11B1)

BTA:	282589(HSD11B1)

BOM:	102275244(HSD11B1)

BIU:	109570467(HSD11B1)

BBUB:

102409054(HSD11B1)

CHX:	102168375(HSD11B1)

OAS:	443409(HSD11B1)

SSC:	397480(HSD11B1)

CFR:	102503994(HSD11B1)

CDK:	105099329(HSD11B1)

BACU:

103004239(HSD11B1)

LVE:	103086619(HSD11B1)

OOR:	101284098(HSD11B1)

DLE:	111184723(HSD11B1)

PCAD:

102992666(HSD11B1)

ECB:	100056429(HSD11B1)

EPZ:	103548673(HSD11B1)

EAI:	106827175(HSD11B1)

MYB:	102260050(HSD11B1)

MYD:	102771648(HSD11B1)

MNA:	107532934(HSD11B1)

DRO:	112297497(HSD11B1)

PALE:

102882377(HSD11B1)

RAY:	107517624(HSD11B1)

MJV:	108396749(HSD11B1)

LAV:	100667019(HSD11B1)

TMU:

101361858

SHR:	100923255(HSD11B1)

PCW:	110222669(HSD11B1)

OAA:	100079059(HSD11B1)

GGA:	419861(HSD11B1b) 771930(HSD11B1a)

MGP:	100550364(HSD11B1) 100550517

CJO:	107324848 107324849

NMEL:

110388207 110388337(HSD11B1)

APLA:

101803228(HSD11B1) 101804020

ACYG:

106041293 106041294

TGU:	100222111 100225021

LSR:	110475377 110475385

SCAN:

103823273 103823329

GFR:	102037915 102038088

FAB:	101815030 101815431

PHI:	102101549 102113769

PMAJ:

107214842 107214843(HSD11B1)

CCAE:

111922428 111939805(HSD11B1)

CCW:	104692327 104692500

ETL:	114063124(HSD11B1) 114063139

FPG:	101918372 101924921

FCH:	102051959 102053319(HSD11B1)

CLV:	102086357(HSD11B1) 102090135

EGZ:	104126798 104126829

NNI:	104010310 104010345

ACUN:

113488855 113488908 113489317

PADL:

103923566 103923602

AAM:	106486285 106490983 106490984

ASN:	102370220 102370459 102376675 102378118 102382863 102383966(HSD11B1)

AMJ:	102559578 102568341(HSD11B1)

PSS:	102459148 102459410 102459465

CMY:	102943559 102946690 102946915

CPIC:

101932631 101940528 101941697

ACS:	100555338(hsd11b1) 100555943

PVT:	110072366(HSD11B1) 110081926

PBI:	103052790 103059600(HSD11B1)

PMUR:

107292272(HSD11B1) 107301624 107301720

TSR:	106539582(HSD11B1)

PMUA:

114586681 114587149 114599353(HSD11B1)

GJA:	107126071(HSD11B1) 107126084

XLA:	108709376(hsd11b1.S) 379494(hsd11b1l.2.L) 379497(hsd11b1.L) 399012(hsd11b1l.L)

XTR:	100038278(hsd11b1l.2) 100489345(hsd11b1)

NPR:	108789677(HSD11B1) 108800094

DRE:	100333777(hsd11b1lb)

SRX:

107750927

CCAR:

109048452

LCM:	102345616(HSD11B1)

CMK:	103182506(hsd11b1)

BFO:

BRAFLDRAFT_121462 BRAFLDRAFT_210861 BRAFLDRAFT_210890 BRAFLDRAFT_210965 BRAFLDRAFT_216418 BRAFLDRAFT_232530 BRAFLDRAFT_264124(Hsd11b1D) BRAFLDRAFT_291087 BRAFLDRAFT_291098 BRAFLDRAFT_73210 BRAFLDRAFT_73306(Hsd11b1M) BRAFLDRAFT_73307 BRAFLDRAFT_84745 BRAFLDRAFT_84746 BRAFLDRAFT_84747 BRAFLDRAFT_86986 BRAFLDRAFT_92730 BRAFLDRAFT_96945 BRAFLDRAFT_96948

SPU:

764876

APLC:

110975185 110975957 110984537

SKO:	100371026 100373877 100374032 100374183 100374331 100374485 100374638 100374683 100374787

HRO:	HELRODRAFT_108742 HELRODRAFT_185224

LGI:	LOTGIDRAFT_138116

PCAN:

112558142

CRG:

105339932

MYI:	110457323 110463419

OBI:

106874424

LAK:	106155319 106155813 106174180 106174574 106174848 106176797 106176813 106176814 106178333 106179027

EPA:

ADF:

AMIL:

PDAM:

SPIS:

DGT:	114518992 114531929

AQU:

100631443

SRE:	PTSG_01197

» show all

Reference

PMID:2808402

Authors

Agarwal AK, Monder C, Eckstein B, White PC

Title

Cloning and expression of rat cDNA encoding corticosteroid 11 beta-dehydrogenase.

Journal

J Biol Chem 264:18939-43 (1989)

Sequence

[rno:25116]

Reference

PMID:15466942

Authors

Tomlinson JW, Walker EA, Bujalska IJ, Draper N, Lavery GG, Cooper MS, Hewison M, Stewart PM

Title

11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response.

Journal

Endocr Rev 25:831-66 (2004)
DOI:10.1210/er.2003-0031

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