KEGG   MODULE: M00114
Entry
M00114            Pathway   Module                                 

Name
Ascorbate biosynthesis, plants, fructose-6P => ascorbate
Definition
K01809 K17497 K00966 K10046 K14190 K10047 K17744 K00225
Diagram
M00114

Orthology
K01809  
mannose-6-phosphate isomerase [EC:5.3.1.8] [RN:R01819]
K17497  
phosphomannomutase [EC:5.4.2.8] [RN:R01818]
K00966  
mannose-1-phosphate guanylyltransferase [EC:2.7.7.13] [RN:R00885]
K10046  
GDP-D-mannose 3', 5'-epimerase [EC:5.1.3.18] [RN:R00889]
K14190  
GDP-L-galactose phosphorylase [EC:2.7.7.69] [RN:R07678]
K10047  
L-galactose 1-phosphate phosphatase [EC:3.1.3.93] [RN:R07674]
K17744  
L-galactose dehydrogenase [EC:1.1.1.316] [RN:R07675]
K00225  
L-galactono-1,4-lactone dehydorogenase [EC:1.3.2.3] [RN:R00640]
Class
Pathway modules; Carbohydrate metabolism; Other carbohydrate metabolism
Pathway
map00051  Fructose and mannose metabolism
map00053  Ascorbate and aldarate metabolism
map01240  Biosynthesis of cofactors
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Reaction
Compound
C05345  beta-D-Fructose 6-phosphate
C00275  D-Mannose 6-phosphate
C00636  D-Mannose 1-phosphate
C00096  GDP-mannose
C02280  GDP-L-galactose
C15926  beta-L-Galactose 1-phosphate
C01825  L-Galactose
C01115  L-Galactono-1,4-lactone
C00072  Ascorbate
Reference
  Authors
Linster CL, Gomez TA, Christensen KC, Adler LN, Young BD, Brenner C, Clarke SG.
  Title
Arabidopsis VTC2 Encodes a GDP-L-Galactose Phosphorylase, the Last Unknown Enzyme in the Smirnoff-Wheeler Pathway to Ascorbic Acid in Plants.
  Journal
J Biol Chem 282:18879-85 (2007)
DOI:10.1074/jbc.M702094200

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