KEGG   MODULE: M00126
Entry
M00126            Pathway   Module                                 

Name
Tetrahydrofolate biosynthesis, GTP => THF
Definition
(K01495,K09007,K22391) (K01077,K01113,(K08310,K19965)) ((K13939,(K13940,K01633 K00950) K00796),(K01633 K13941)) (K11754,K20457) (K00287,K13998)
Diagram
M00126

Orthology
GTP cyclohydrolase I [EC:3.5.4.16] [RN:R00428 R05046 R05048 R04639]
alkaline phosphatase [EC:3.1.3.1] [RN:R04620]
dihydroneopterin triphosphate diphosphatase [EC:3.6.1.67] [RN:R04638]
dihydroneopterin aldolase [EC:4.1.2.25] [RN:R03504]
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase [EC:2.7.6.3] [RN:R03503]
dihydropteroate synthase [EC:2.5.1.15] [RN:R03066 R03067]
dihydrofolate synthase [EC:6.3.2.12] [RN:R02237]
dihydrofolate reductase [EC:1.5.1.3] [RN:R00936 R00939]
Class
Pathway modules; Metabolism of cofactors and vitamins; Cofactor and vitamin metabolism
Pathway
map00790  Folate biosynthesis
map00670  One carbon pool by folate
map01240  Biosynthesis of cofactors
map01100  Metabolic pathways
Reaction
Compound
C00044  GTP
C05922  Formamidopyrimidine nucleoside triphosphate
C05923  2,5-Diaminopyrimidine nucleoside triphosphate
C06148  2,5-Diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine
C04895  7,8-Dihydroneopterin 3'-triphosphate
C04874  7,8-Dihydroneopterin
C05925  Dihydroneopterin phosphate
C01300  6-(Hydroxymethyl)-7,8-dihydropterin
C04807  6-Hydroxymethyl-7,8-dihydropterin diphosphate
C00921  Dihydropteroate
C00415  Dihydrofolate
C00101  Tetrahydrofolate

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