KEGG   MODULE: M00622
Entry
M00622            Pathway   Module                                 

Name
Nicotinate degradation, nicotinate => fumarate
Definition
K18029+K18030 K14974 K18028 K15357 K13995 K01799
Diagram
M00622

Orthology
nicotinate dehydrogenase  [EC:1.17.2.1] [RN:R09473]
K14974  
6-hydroxynicotinate 3-monooxygenase [EC:1.14.13.114] [RN:R08764]
K18028  
2,5-dihydroxypyridine 5,6-dioxygenase [EC:1.13.11.9] [RN:R09125]
K15357  
N-formylmaleamate deformylase [EC:3.5.1.106] [RN:R09126]
K13995  
maleamate amidohydrolase [EC:3.5.1.107] [RN:R03540]
K01799  
maleate isomerase [EC:5.2.1.1] [RN:R01087]
Class
Pathway modules; Metabolism of cofactors and vitamins; Cofactor and vitamin metabolism
Pathway
map00760  Nicotinate and nicotinamide metabolism
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
Reaction
Compound
C00253  Nicotinate
C01020  6-Hydroxynicotinate
C01059  2,5-Dihydroxypyridine
C18232  N-Formylmaleamic acid
C01596  Maleamate
C01384  Maleic acid
C00122  Fumarate
Reference
  Authors
Jimenez JI, Canales A, Jimenez-Barbero J, Ginalski K, Rychlewski L, Garcia JL, Diaz E
  Title
Deciphering the genetic determinants for aerobic nicotinic acid degradation: the nic cluster from Pseudomonas putida KT2440.
  Journal
Proc Natl Acad Sci U S A 105:11329-34 (2008)
DOI:10.1073/pnas.0802273105

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