KEGG   MODULE: M00661
Entry
M00661            Pathway   Module                                 

Name
Paspaline biosynthesis, geranylgeranyl-PP + indoleglycerol phosphate => paspaline
Definition
K18385 K18386 K18387
Diagram
M00661

Orthology
K18385  
geranylgeranyldiphosphate transferase [RN:R10349]
K18386  
FAD dependent monooxygenase [EC:1.14.13.-] [RN:R10350 R10351]
K18387  
paspaline synthase [RN:R10352 R10353]
Class
Pathway modules; Biosynthesis of other secondary metabolites; Biosynthesis of other fungal compounds
Pathway
map00403  Indole diterpene alkaloid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Reaction
Compound
C00353  Geranylgeranyl diphosphate
C03506  Indoleglycerol phosphate
C20525  3-Geranylgeranylindole
C20526  10,11-Epoxy-3-geranylgeranylindole
C20527  Emindole SB
C20529  14,15-Epoxyemindole SB
C20530  Paspaline
Reference
  Authors
Tagami K, Liu C, Minami A, Noike M, Isaka T, Fueki S, Shichijo Y, Toshima H, Gomi K, Dairi T, Oikawa H
  Title
Reconstitution of biosynthetic machinery for indole-diterpene paxilline in Aspergillus oryzae.
  Journal
J Am Chem Soc 135:1260-3 (2013)
DOI:10.1021/ja3116636

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