KEGG   MODULE: M00776
Entry
M00776            Pathway   Module                                 
Name
Pikromycin/methymycin biosynthesis, methylmalonyl-CoA + malonyl-CoA => narbonolide/10-deoxymethynolide => pikromycin/methymycin
Definition
K16000+K16001+K16002-K16003 K16004 K16005 K16006
Diagram
M00776

Orthology
K16000  
pikAI; narbonolide/10-deoxymethynolide synthase [EC:2.3.1.240 2.3.1.239] [RN:R06459 R06458]
K16001  
pikAII; narbonolide/10-deoxymethynolide synthase [EC:2.3.1.240 2.3.1.239] [RN:R06459 R06458]
K16002  
pikAIII; narbonolide/10-deoxymethynolide synthase [EC:2.3.1.240 2.3.1.239] [RN:R06459 R06458]
K16003  
pikAIV; narbonolide synthase [EC:2.3.1.240] [RN:R06459]
K16004  
desVII; narbonolide/10-deoxymethynolide desosaminyltransferase [EC:2.4.1.277] [RN:R06461 R06460]
K16005  
desVIII; narbonolide/10-deoxymethynolide desosaminyltransferase auxiliary protein [RN:R06461 R06460]
K16006  
pikC; pikromycin synthase [EC:1.14.15.33] [RN:R06464 R06463]
Class
Pathway modules; Biosynthesis of terpenoids and polyketides; Macrolide biosynthesis
Pathway
map00522  Biosynthesis of 12-, 14- and 16-membered macrolides
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Reaction
R06459  
R06461  
R06464  
R06458  
R06460  
R06463  
Compound
C00683  (S)-Methylmalonyl-CoA
C00083  Malonyl-CoA
C11997  Narbonolide
C11998  Narbomycin
C11999  Pikromycin
C11993  10-Deoxymethynolide
C11994  10-Deoxymethymycin
C11996  Methymycin
Reference
PMID:19027305
  Authors
Kittendorf JD, Sherman DH
  Title
The methymycin/pikromycin pathway: a model for metabolic diversity in natural product biosynthesis.
  Journal
Bioorg Med Chem 17:2137-46 (2009)
DOI:10.1016/j.bmc.2008.10.082

  All links  
Pathway (3)   
   KEGG PATHWAY (3)   
Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (10)   
   KEGG ENZYME (4)   
   KEGG REACTION (6)   
Gene (7)   
   KEGG ORTHOLOGY (7)   
Literature (1)   
   PubMed (1)   
All databases (29)   

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