KEGG   MODULE: M00780Help
Entry
M00780            Pathway   Module                                 

Name
Tetracycline/oxytetracycline biosynthesis, pretetramide => tetracycline/oxytetracycline
Definition
K14251 K14252 K14253 K14254 K14255 K14256 K21301
Module map
M00780

Orthology
K14251  
oxyF; C-methyltransferase [EC:2.1.1.-] [RN:R09189]
K14252  
oxyL; 6-methylpretetramide 4-monooxygenase / 4-hydroxy-6-methylpretetramide 12a-monooxygenase [EC:1.14.13.232 1.14.13.233] [RN:R09190 R05462]
K14253  
oxyE; 6-methylpretetramide 4-monooxygenase [EC:1.14.13.232] [RN:R05463]
K14254  
oxyQ; aminotransferase [RN:R09197]
K14255  
oxyT, ctcO, cts6; 4-amino-anhydrotetracycline N4-methyltransferase [EC:2.1.1.335] [RN:R09191]
K14256  
oxyS, cts8; anhydrotetracycline 6-monooxygenase / 5a,11a-dehydrotetracycline 5-monooxygenase [EC:1.14.13.38 1.14.13.234] [RN:R04060 R09198]
K21301  
oxyR; 5a,11a-dehydrotetracycline reductase [EC:1.3.98.4] [RN:R09192 R05459]
Ortholog tableTaxonomy
Class
Pathway modules; Biosynthesis of terpenoids and polyketides; Type II polyketide biosynthesis
BRITE hierarchy
Pathway
map00253  Tetracycline biosynthesis
map01057  Biosynthesis of type II polyketide products
map01100  Metabolic pathways
map01130  Biosynthesis of antibiotics
Reaction
Compound
C18295  Pretetramid
C06629  6-Methylpretetramide
C06628  4-Hydroxy-6-methylpretetramide
C06627  4-Keto-anhydrotetracycline
C06654  4-Amino-anhydrotetracycline
C02811  Anhydrotetracycline
C03206  5a,11a-Dehydrotetracycline
C06570  Tetracycline
C18296  5a,11a-Dehydrooxytetracycline
C06624  Oxytetracycline
RModule
RM035  Transamination and N,N-dimethylation in polyketide biosynthesis

DBGET integrated database retrieval system