KEGG   MODULE: M00810
Entry
M00810            Pathway   Module                                 

Name
Nicotine degradation, pyridine pathway, nicotine => 2,6-dihydroxypyridine/succinate semialdehyde
Definition
K19818+K19819+K19820 (K19826,K19890) K19185+K19186+K19187 K19188 -K20155
Diagram
M00810

Orthology
nicotine dehydrogenase [EC:1.5.99.4] [RN:R02860 R07946]
K19826  
(S)-6-hydroxynicotine oxidase [EC:1.5.3.5] [RN:R11048]
K19890  
(R)-6-hydroxynicotine oxidase [EC:1.5.3.6] [RN:R11050]
6-hydroxypseudooxynicotine dehydrogenase [EC:1.5.99.14] [RN:R07514]
K19188  
2,6-dihydroxypseudooxynicotine hydrolase [EC:3.7.1.19] [RN:R07515]
K20155  
4-methylaminobutanoate oxidase (methylamine-forming) [EC:1.5.3.21] [RN:R10101]
Class
Pathway modules; Metabolism of cofactors and vitamins; Cofactor and vitamin metabolism
Pathway
map00760  Nicotinate and nicotinamide metabolism
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
Reaction
Compound
C16150  (R,S)-Nicotine
C01056  (S)-6-Hydroxynicotine
C21075  5-(N-Methyl-4,5-dihydro-1H-pyrrol-2-yl)pyridin-2-ol
C03043  (R)-6-Hydroxynicotine
C01297  6-Hydroxypseudooxynicotine
C15986  2,6-Dihydroxypseudooxynicotine
C03056  2,6-Dihydroxypyridine
C15987  4-Methylaminobutyrate
C00232  Succinate semialdehyde
Reference
  Authors
Qiu J, Ma Y, Wen Y, Chen L, Wu L, Liu W
  Title
Functional identification of two novel genes from Pseudomonas sp. strain HZN6 involved in the catabolism of nicotine.
  Journal
Appl Environ Microbiol 78:2154-60 (2012)
DOI:10.1128/AEM.07025-11

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