KEGG   MODULE: M00814
Entry
M00814            Pathway   Module                                 

Name
Acarbose biosynthesis, sedoheptulopyranose-7P => acarbose
Definition
K19969 K19979 K19974 K20424 K20425 K20426 K20427 K20430 -- --
Diagram
M00814

Orthology
K19969  
acbC; 2-epi-5-epi-valiolone synthase [EC:4.2.3.152] [RN:R10937]
K19979  
acbM; 2-epi-5-epi-valiolone 7-kinase [EC:2.7.1.188] [RN:R11185]
K19974  
acbO; 2-epi-5-epi-valiolone 7-phosphate 2-epimerase [EC:5.1.3.35] [RN:R11081]
K20424  
acbL; 2-epi-valiolone-7-phosphate 1-reductase [EC:1.1.1.-]  [RN:R11243]
K20425  
acbN; cyclitol oxidoreductase [RN:R11244]
K20426  
acbU; 1-epi-valienol-7-phosphate kinase [EC:2.7.-.-] [RN:R11245]
K20427  
acbR; 1-epi-valienol 1,7-diphosphate adenylyltransferases [EC:2.7.7.-]  [RN:R11246]
K20430  
acbS; glycosyltransferase AcbS [EC:2.4.-.-] [RN:R11247]
Class
Pathway modules; Biosynthesis of other secondary metabolites; Biosynthesis of other bacterial compounds
Pathway
map00525  Acarbose and validamycin biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Reaction
Compound
C20956  alpha-D-Sedoheptulopyranose 7-phosphate
C17691  2-epi-5-epi-Valiolone
C17692  2-epi-5-epi-Valiolone 7-phosphate
C17693  5-epi-Valiolone 7-phosphate
C21204  5-epi-Valiolol 7-phosphate
C21205  1-epi-Valienol 7-phosphate
C21206  1,7-diphospho-1-epi-valienol
C21207  NDP-1-epi-valienol 7-phosphate
C04268  dTDP-4-amino-4,6-dideoxy-D-glucose
C21208  dTDP-acarviose-7-phosphate
C21156  Acarbose 7IV-phosphate
C06802  Acarbose
Reference
  Authors
Wendler S, Hurtgen D, Kalinowski J, Klein A, Niehaus K, Schulte F, Schwientek P, Wehlmann H, Wehmeier UF, Puhler A
  Title
The cytosolic and extracellular proteomes of Actinoplanes sp. SE50/110 led to the identification of gene products involved in acarbose metabolism.
  Journal
J Biotechnol 167:178-89 (2013)
DOI:10.1016/j.jbiotec.2012.08.011
Reference
  Authors
Rockser Y, Wehmeier UF
  Title
The gac-gene cluster for the production of acarbose from Streptomyces glaucescens GLA.O: identification, isolation and characterization.
  Journal
J Biotechnol 140:114-23 (2009)
DOI:10.1016/j.jbiotec.2008.10.016

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