KEGG   MODULE: M00823
Entry
M00823            Pathway   Module                                 
Name
Chlortetracycline biosynthesis, pretetramide => chlortetracycline
Definition
K14251 K14252 K14253 K14254 K14255 K14256 K21301 K14257+K21297
Diagram
M00823

Orthology
K14251  
oxyF; C-methyltransferase [EC:2.1.1.-] [RN:R09189]
K14252  
oxyL; 6-methylpretetramide 4-monooxygenase / 4-hydroxy-6-methylpretetramide 12a-monooxygenase [EC:1.14.13.232 1.14.13.233] [RN:R09190 R05462]
K14253  
oxyE; 6-methylpretetramide 4-monooxygenase [EC:1.14.13.232] [RN:R05463]
K14254  
oxyQ; aminotransferase [RN:R09197]
K14255  
oxyT, ctcO, cts6; 4-amino-anhydrotetracycline N4-methyltransferase [EC:2.1.1.335] [RN:R09191]
K14256  
oxyS, cts8; anhydrotetracycline 6-monooxygenase / 5a,11a-dehydrotetracycline 5-monooxygenase [EC:1.14.13.38 1.14.13.234] [RN:R04060 R09198]
K21301  
oxyR; 5a,11a-dehydrotetracycline reductase [EC:1.3.98.4] [RN:R09192 R05459]
K14257  
ctcP; tetracycline 7-halogenase [EC:1.14.19.49] [RN:R11478]
K21297  
ctcQ; flavin reductase (NADH) [EC:1.5.1.36]
Class
Pathway modules; Biosynthesis of terpenoids and polyketides; Type II polyketide biosynthesis
Pathway
map00253  Tetracycline biosynthesis
map01057  Biosynthesis of type II polyketide products
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Reaction
R09189  
R05463  
R05462  
R09190  
R09197  
R09191  
R04060  
R05459  
R11478  
Compound
C18295  Pretetramid
C06629  6-Methylpretetramide
C06628  4-Hydroxy-6-methylpretetramide
C06627  4-Keto-anhydrotetracycline
C06654  4-Amino-anhydrotetracycline
C02811  Anhydrotetracycline
C03206  5a,11a-Dehydrotetracycline
C06570  Tetracycline
C06571  Chlortetracycline
RModule
RM035  Transamination and N,N-dimethylation in polyketide biosynthesis

  All links  
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (9)   
   KEGG COMPOUND (9)   
Chemical reaction (17)   
   KEGG ENZYME (8)   
   KEGG REACTION (9)   
Gene (9)   
   KEGG ORTHOLOGY (9)   
All databases (39)   

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