KEGG   MODULE: M00835
Entry
M00835            Pathway   Module                                 

Name
Pyocyanine biosynthesis, chorismate => pyocyanine
Definition
K13063 K20261 K06998 K20260 K20262 K21103 K20940
Diagram
M00835

Orthology
K13063  
phzE; 2-amino-4-deoxychorismate synthase [EC:2.6.1.86] [RN:R08956]
K20261  
phzD; trans-2,3-dihydro-3-hydroxyanthranilic acid synthase [EC:3.3.2.15][RN:R11463]
K06998  
phzF; trans-2,3-dihydro-3-hydroxyanthranilate isomerase [EC:5.3.3.17] [RN:R09707]
K20260  
phzA_B; phenazine biosynthesis protein [RN:R11568 R11569]
K20262  
phzG; dihydrophenazinedicarboxylate synthase [EC:1.10.3.16][RN:R11491]
K21103  
phzM; phenazine-1-carboxylate N-methyltransferase [EC:2.1.1.327][RN:R11533]
K20940  
phzS; 5-methylphenazine-1-carboxylate 1-monooxygenase [EC:1.14.13.218][RN:R11346]
Class
Pathway modules; Biosynthesis of other secondary metabolites; Biosynthesis of other bacterial compounds
Pathway
map00405  Phenazine biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Reaction
Compound
C00251  Chorismate
C18054  2-Amino-2-deoxyisochorismate
C19830  (5S,6S)-6-Amino-5-hydroxycyclohexa-1,3-diene-1-carboxylate
C19831  (1R,6S)-6-Amino-5-oxocyclohex-2-ene-1-carboxylate
C21473  (1R,5aS,6R)-4a-Hydroxy-1,4,4a,5,5a,6,9,10a-octahydrophenazine-1,6-dicarboxylate
C21408  (1R,6R)-1,4,5,5a,6,9-Hexahydrophenazine-1,6-dicarboxylate
C21411  (1R,10aS)-1,4,10,10a-Tetrahydrophenazine-1-carboxylate
C21412  (10aS)-10,10a-Dihydrophenazine-1-carboxylate
C20981  5,10-Dihydrophenazine-1-carboxylate
C21442  Phenazine-1-carboxylate
C21295  5-Methylphenazine-1-carboxylate
C01748  Pyocyanine
Reference
  Authors
Xu N, Ahuja EG, Janning P, Mavrodi DV, Thomashow LS, Blankenfeldt W
  Title
Trapped intermediates in crystals of the FMN-dependent oxidase PhzG provide insight into the final steps of phenazine biosynthesis.
  Journal
Acta Crystallogr D Biol Crystallogr 69:1403-13 (2013)
DOI:10.1107/S0907444913008354
Reference
  Authors
Parsons JF, Greenhagen BT, Shi K, Calabrese K, Robinson H, Ladner JE
  Title
Structural and functional analysis of the pyocyanin biosynthetic protein PhzM from Pseudomonas aeruginosa.
  Journal
Biochemistry 46:1821-8 (2007)
DOI:10.1021/bi6024403

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