KEGG   MODULE: M00840
Entry
M00840            Pathway   Module                                 

Name
Tetrahydrofolate biosynthesis, mediated by ribA and trpF, GTP => THF
Definition
K14652 K22100 -- K01633 K13941 K22099 K00287
Diagram
M00840

Orthology
K14652  
GTP cyclohydrolase II [EC:3.5.4.25] [RN:R00425]
K22100  
2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one isomerase/dehydratase [EC:4.2.1.160] [RN:R11072]
K01633  
7,8-dihydroneopterin aldolase [EC:4.1.2.25] [RN:R03504]
K13941  
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase / dihydropteroate synthase [EC:2.7.6.3 2.5.1.15] [RN:R03503 R03066 R03067]
K22099  
dihydrofolate synthase [EC:6.3.2.12] [RN:R02237]
K00287  
dihydrofolate reductase [EC:1.5.1.3] [RN:R00936 R00939]
Class
Pathway modules; Metabolism of cofactors and vitamins; Cofactor and vitamin metabolism
Pathway
map00790  Folate biosynthesis
map01240  Biosynthesis of cofactors
map01100  Metabolic pathways
Reaction
Compound
C00044  GTP
C01304  2,5-Diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one
C05925  Dihydroneopterin phosphate
C04874  7,8-Dihydroneopterin
C01300  6-(Hydroxymethyl)-7,8-dihydropterin
C04807  6-Hydroxymethyl-7,8-dihydropterin diphosphate
C00921  Dihydropteroate
C00415  Dihydrofolate
C00101  Tetrahydrofolate
Reference
  Authors
Adams NE, Thiaville JJ, Proestos J, Juarez-Vazquez AL, McCoy AJ, Barona-Gomez F, Iwata-Reuyl D, de Crecy-Lagard V, Maurelli AT
  Title
Promiscuous and adaptable enzymes fill "holes" in the tetrahydrofolate pathway in Chlamydia species.
  Journal
MBio 5:e01378-14 (2014)
DOI:10.1128/mBio.01378-14

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