KEGG   MODULE: M00848
Entry
M00848            Pathway   Module                                 

Name
Aurachin biosynthesis, anthranilate => aurachin A
Definition
K09460 K02078+K14245+K14246+K22798 K22799 K22800 K21272 K21271 K22801 K22802
Diagram
M00848

Orthology
K09460  
auaEII; anthranilate-CoA ligase [EC:6.2.1.32] [RN:R00982]
K02078  
auaB; acyl carrier protein [RN:R12049]
K14245  
auaC; PKS ketosynthase (KS/KS alpha) [EC:2.3.1.-] [RN:R12049]
K14246  
auaD; PKS chain-length factor (CLF/KS beta) [EC:2.3.1.-] [RN:R12049]
K22798  
auaE; anthranilate-CoA-ACP transferase [EC:6.2.1.-] [RN:R12049]
K22799  
auaA; 2-methyl-4-hydroxyquinoline prenyltransferase [EC:2.5.1.-] [RN:R12050]
K22800  
auaF; aurachin D monooxygenase [EC:1.14.13.-] [RN:R12051]
K21272  
auaG; aurachin C monooxygenase/isomerase [EC:1.14.13.222] [RN:R11382 R11383]
K21271  
auaH; aurachin B dehydrogenase [EC:1.1.1.394] [RN:R11149]
K22801  
auaJ; aurachin B monooxygenase [EC:1.14.13.-] [RN:R12052 R12053]
K22802  
auaI; aurichin B epoxide hydrolase [RN:R12054]
Class
Pathway modules; Biosynthesis of other secondary metabolites; Biosynthesis of other antibiotics
Pathway
map00998  Biosynthesis of various secondary metabolites - part 2
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Reaction
Compound
C00108  Anthranilate
C02247  Anthraniloyl-CoA
C21873  2-Methylquinolin-4-ol
C10641  Aurachin D
C21330  Aurachin C
C21141  4-Hydroxy-2-methyl-3-oxo-4-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide
C21140  Aurachin B
C21874  Aurachin B epoxide
C21875  Aurachin A
Reference
  Authors
Pistorius D, Li Y, Mann S, Muller R
  Title
Unprecedented anthranilate priming involving two enzymes of the acyl adenylating superfamily in aurachin biosynthesis.
  Journal
J Am Chem Soc 133:12362-5 (2011)
DOI:10.1021/ja203653w
Reference
  Authors
Sandmann A, Dickschat J, Jenke-Kodama H, Kunze B, Dittmann E, Muller R
  Title
A Type II polyketide synthase from the gram-negative Bacterium Stigmatella aurantiaca is involved in Aurachin alkaloid biosynthesis.
  Journal
Angew Chem Int Ed Engl 46:2712-6 (2007)
DOI:10.1002/anie.200603513
Reference
  Authors
Kitagawa W, Ozaki T, Nishioka T, Yasutake Y, Hata M, Nishiyama M, Kuzuyama T, Tamura T
  Title
Cloning and heterologous expression of the aurachin RE biosynthesis gene cluster afford a new cytochrome P450 for quinoline N-hydroxylation.
  Journal
Chembiochem 14:1085-93 (2013)
DOI:10.1002/cbic.201300167

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