KEGG   MODULE: M00898
Entry
M00898            Pathway   Module                                 
Name
Thiamine biosynthesis, pyridoxal-5P => TMP/thiamine/TPP
Definition
K03146
K18278 K00877 K14154 -- K00949
Diagram
M00898

Orthology
K03146  
THI4; cysteine-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.60] [RN:R10685]
K18278  
THI5; pyrimidine precursor biosynthesis enzyme [RN:R10686]
K00877  
THI20; phosphomethylpyrimidine kinase [EC:2.7.4.7] [RN:R04509]
K14154  
THI6; thiamine-phosphate diphosphorylase [EC:2.5.1.3] [RN:R10712]
K00949  
THI80; thiamine pyrophosphokinase [EC:2.7.6.2] [RN:R00619]
Class
Pathway modules; Metabolism of cofactors and vitamins; Cofactor and vitamin metabolism
Pathway
map00730  Thiamine metabolism
map01240  Biosynthesis of cofactors
map01100  Metabolic pathways
Reaction
R10685  
R10711  
R10686  
R04509  
R10712  
R02135  
R00619  
Compound
C00037  Glycine
C00003  NAD+
C20784  ADP-5-ethyl-4-methylthiazole-2-carboxylate
C20247  2-(2-Carboxy-4-methylthiazol-5-yl)ethyl phosphate
C00018  Pyridoxal phosphate
C04556  4-Amino-2-methyl-5-(phosphooxymethyl)pyrimidine
C04752  4-Amino-5-hydroxymethyl-2-methylpyrimidine diphosphate
C01081  Thiamin monophosphate
C00378  Thiamine
C00068  Thiamin diphosphate
Reference
PMID:18161008
  Authors
Kowalska E, Kozik A
  Title
The genes and enzymes involved in the biosynthesis of thiamin and thiamin diphosphate in yeasts.
  Journal
Cell Mol Biol Lett 13:271-82 (2008)
DOI:10.2478/s11658-007-0055-5

  All links  
Pathway (3)   
   KEGG PATHWAY (3)   
Chemical substance (10)   
   KEGG COMPOUND (10)   
Chemical reaction (14)   
   KEGG ENZYME (7)   
   KEGG REACTION (7)   
Gene (5)   
   KEGG ORTHOLOGY (5)   
Literature (1)   
   PubMed (1)   
All databases (33)   

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