KEGG   MODULE: M00909
Entry
M00909            Pathway   Module                                 

Name
UDP-N-acetyl-D-glucosamine biosynthesis, prokaryotes, glucose => UDP-GlcNAc
Definition
K00845 (K01810,K13810,K15916) K00820 K03431 K04042
Diagram
M00909

Orthology
K00845  
glk; glucokinase [EC:2.7.1.2] [RN:R01786]
pgi; glucose-6-phosphate isomerase [EC:5.3.1.9] [RN:R02740]
K00820  
glmS; glutamine---fructose-6-phosphate transaminase (isomerizing) [EC:2.6.1.16] [RN:R00768]
K03431  
glmM; phosphoglucosamine mutase [EC:5.4.2.10] [RN:R02060]
K04042  
glmU; bifunctional UDP-N-acetylglucosamine pyrophosphorylase / Glucosamine-1-phosphate N-acetyltransferase [EC:2.7.7.23 2.3.1.157] [RN:R05332 R00416]
Class
Pathway modules; Carbohydrate metabolism; Other carbohydrate metabolism
Pathway
map00520  Amino sugar and nucleotide sugar metabolism
map01100  Metabolic pathways
Reaction
Compound
C00267  alpha-D-Glucose
C00668  alpha-D-Glucose 6-phosphate
C05345  beta-D-Fructose 6-phosphate
C00352  D-Glucosamine 6-phosphate
C06156  alpha-D-Glucosamine 1-phosphate
C04501  N-Acetyl-alpha-D-glucosamine 1-phosphate
C00043  UDP-N-acetyl-alpha-D-glucosamine
Reference
PMID:8083170
  Authors
Mengin-Lecreulx D, van Heijenoort J
  Title
Copurification of glucosamine-1-phosphate acetyltransferase and N-acetylglucosamine-1-phosphate uridyltransferase activities of Escherichia coli: characterization of the glmU gene product as a bifunctional enzyme catalyzing two subsequent steps in the pathway for UDP-N-acetylglucosamine synthesis.
  Journal
J Bacteriol 176:5788-95 (1994)
DOI:10.1128/jb.176.18.5788-5795.1994
Reference
  Authors
Teplyakov A, Obmolova G, Badet-Denisot MA, Badet B
  Title
The mechanism of sugar phosphate isomerization by glucosamine 6-phosphate synthase.
  Journal
Protein Sci 8:596-602 (1999)
DOI:10.1110/ps.8.3.596

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