KEGG   MODULE: M00921
Entry
M00921            Pathway   Module                                 

Name
Cyclooctatin biosynthesis, dimethylallyl-PP + isopentenyl-PP => cyclooctatin
Definition
K13787 K18686 K22997 K22998
Diagram
M00921

Orthology
K13787  
cotB1; geranylgeranyl diphosphate synthase [EC:2.5.1.1 2.5.1.10 2.5.1.29] [RN:R01658 R02003 R02061]
K18686  
cotB2; cyclooctat-9-en-7-ol synthase [EC:4.2.3.146] [RN:R10763]
K22997  
cotB3; cyclooctat-9-en-7-ol 5-monooxygenase [EC:1.14.99.61] [RN:R12177]
K22998  
cotB4; cyclooctatin synthase [EC:1.14.99.62] [RN:R12178]
Class
Pathway modules; Biosynthesis of other secondary metabolites; Biosynthesis of other bacterial compounds
Pathway
map00900  Terpenoid backbone biosynthesis
map00999  Biosynthesis of various secondary metabolites - part 1
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Reaction
Compound
C00235  Dimethylallyl diphosphate
C00129  Isopentenyl diphosphate
C00341  Geranyl diphosphate
C00448  trans,trans-Farnesyl diphosphate
C00353  Geranylgeranyl diphosphate
C20834  Cyclooctat-9-en-7-ol
C21978  Cyclooctat-9-ene-5,7-diol
C21979  Cyclooctatin
Reference
  Authors
Kim SY, Zhao P, Igarashi M, Sawa R, Tomita T, Nishiyama M, Kuzuyama T
  Title
Cloning and heterologous expression of the cyclooctatin biosynthetic gene cluster afford a diterpene cyclase and two p450 hydroxylases.
  Journal
Chem Biol 16:736-43 (2009)
DOI:10.1016/j.chembiol.2009.06.007

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