Entry |
|
Name |
Amplified PDGFR to RAS-ERK signaling pathway
|
Definition |
PDGFR* -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK |
Expanded |
5156v1 -> 2885 -> (6654,6655) -> (3265,3845,4893) -> (369,673,5894) -> (5604,5605) -> (5594,5595) |
Class |
|
Type |
Variant
|
Pathway |
|
Disease |
|
Gene |
5156 | PDGFRA; platelet derived growth factor receptor alpha |
2885 | GRB2; growth factor receptor bound protein 2 |
6654 | SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 |
6655 | SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 |
3265 | HRAS; HRas proto-oncogene, GTPase |
3845 | KRAS; KRAS proto-oncogene, GTPase |
4893 | NRAS; NRAS proto-oncogene, GTPase |
369 | ARAF; A-Raf proto-oncogene, serine/threonine kinase |
673 | BRAF; B-Raf proto-oncogene, serine/threonine kinase |
5894 | RAF1; Raf-1 proto-oncogene, serine/threonine kinase |
5604 | MAP2K1; mitogen-activated protein kinase kinase 1 |
5605 | MAP2K2; mitogen-activated protein kinase kinase 2 |
5594 | MAPK1; mitogen-activated protein kinase 1 |
5595 | MAPK3; mitogen-activated protein kinase 3 |
|
Variant |
5156v1 (PDGFR*) PDGFRA amplification
|
Reference |
|
Authors |
Westermark B |
Title |
Platelet-derived growth factor in glioblastoma-driver or biomarker? |
Journal |
|
Reference |
|
Authors |
Soni D, King JA, Kaye AH, Hovens CM. |
Title |
Genetics of glioblastoma multiforme: mitogenic signaling and cell cycle pathways converge. |
Journal |
|
Reference |
|
Authors |
Bansal K, Liang ML, Rutka JT. |
Title |
Molecular biology of human gliomas. |
Journal |
|