KEGG   NETWORK: N00065
Entry
N00065                      Network                                
Name
Mutation-inactivated SMAD2 to TGF-beta signaling pathway
Definition
(TGFBR2+TGFBR1) // (SMAD2*,SMAD3)
  Expanded
(7048+7046) // (4087v1,4088)
Class
nt06260 Colorectal cancer
nt06218 TGFB signaling (cancer)
Type
Variant
Pathway
hsa05210  Colorectal cancer
Disease
H00020  Colorectal cancer
Gene
7048  TGFBR2; transforming growth factor beta receptor 2
7046  TGFBR1; transforming growth factor beta receptor 1
4087  SMAD2; SMAD family member 2
4088  SMAD3; SMAD family member 3
Variant
4087v1 (SMAD2*)  SMAD2 mutation
Reference
PMID:11170304
  Authors
Roman C, Saha D, Beauchamp R.
  Title
TGF-beta and colorectal carcinogenesis.
  Journal
Microsc Res Tech 52:450-7 (2001)
DOI:10.1002/1097-0029(20010215)52:4<450::AID-JEMT1030>3.0.CO;2-O
Reference
PMID:15711891
  Authors
Li F, Cao Y, Townsend CM Jr, Ko TC.
  Title
TGF-beta signaling in colon cancer cells.
  Journal
World J Surg 29:306-11 (2005)
DOI:10.1007/s00268-004-7813-6
Reference
PMID:10793168
  Authors
Blobe GC, Schiemann WP, Lodish HF
  Title
Role of transforming growth factor beta in human disease.
  Journal
N Engl J Med 342:1350-8 (2000)
DOI:10.1056/NEJM200005043421807

  All links  
Pathway (1)   
   KEGG PATHWAY (1)   
Network (1)   
   KEGG VARIANT (1)   
Gene (4)   
   KEGG GENES (4)   
Literature (3)   
   PubMed (3)   
All databases (9)   

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