Entry |
|
Name |
Amplified MYC to p27-cell cycle G1/S
|
Definition |
(MYC*+MAX) => CKS1B -> (SCF+SKP2) -| CDKN1B -| (CCNE+CDK2) -> RB1 // E2F |
Expanded |
(4609v1+4149) => 1163 -> (6500+8454+9978+6502) -| 1027 -| ((898,9134)+1017) -> 5925 // (1869,1870,1871) |
Class |
|
Type |
Variant
|
Pathway |
|
Disease |
|
Gene |
4609 | MYC; MYC proto-oncogene, bHLH transcription factor |
4149 | MAX; MYC associated factor X |
1163 | CKS1B; CDC28 protein kinase regulatory subunit 1B |
6500 | SKP1; S-phase kinase associated protein 1 |
6502 | SKP2; S-phase kinase associated protein 2 |
1027 | CDKN1B; cyclin dependent kinase inhibitor 1B |
1017 | CDK2; cyclin dependent kinase 2 |
5925 | RB1; RB transcriptional corepressor 1 |
1869 | E2F1; E2F transcription factor 1 |
1870 | E2F2; E2F transcription factor 2 |
1871 | E2F3; E2F transcription factor 3 |
|
Variant |
4609v1 (MYC*) MYC amplification
|
Reference |
|
Authors |
Osada H, Takahashi T. |
Title |
Genetic alterations of multiple tumor suppressors and oncogenes in the carcinogenesis and progression of lung cancer. |
Journal |
|
Reference |
|
Authors |
Spruck C, Strohmaier H, Watson M, Smith AP, Ryan A, Krek TW, Reed SI. |
Title |
A CDK-independent function of mammalian Cks1: targeting of SCF(Skp2) to the CDK inhibitor p27Kip1. |
Journal |
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