Entry |
|
Name |
HPV E6 to Notch signaling pathway
|
Definition |
E6 -> JAG1 -> NOTCH -> (NICD+RBPJ+MAML) => (HES1,HEY1) |
Expanded |
K21807 -> 182 -> (4851,4853,4854,4855) -> (C22528+(3516,11317)+(9794,84441,55534)) => (3280,23462) |
Class |
|
Type |
Pathogen
|
Pathway |
|
Disease |
|
Gene |
3516 | RBPJ; recombination signal binding protein for immunoglobulin kappa J region |
11317 | RBPJL; recombination signal binding protein for immunoglobulin kappa J region like |
9794 | MAML1; mastermind like transcriptional coactivator 1 |
84441 | MAML2; mastermind like transcriptional coactivator 2 |
55534 | MAML3; mastermind like transcriptional coactivator 3 |
3280 | HES1; hes family bHLH transcription factor 1 |
23462 | HEY1; hes related family bHLH transcription factor with YRPW motif 1 |
|
Perturbant |
K21807 (E6) | E6; HPV protein E6 |
|
Metabolite |
C22528 | Notch intracellular domain |
|
Reference |
|
Authors |
Chen J |
Title |
Signaling pathways in HPV-associated cancers and therapeutic implications. |
Journal |
|
Reference |
|
Authors |
Veeraraghavalu K, Pett M, Kumar RV, Nair P, Rangarajan A, Stanley MA, Krishna S |
Title |
Papillomavirus-mediated neoplastic progression is associated with reciprocal changes in JAGGED1 and manic fringe expression linked to notch activation. |
Journal |
|