KEGG   NETWORK: N00487
Entry
N00487                      Network                                
Name
BCR-PLCG-Calcineurin signaling pathway
Definition
IGH -> (LYN,SYK) -> (BTK,BLNK) -> PLCG2 -> IP3 -> Ca2+ -> CALM == CN -> NFAT
  Expanded
102723407 -> (4067,6850) -> (695,29760) -> 5336 -> C01245 -> C00076 -> (801,805,808) == (5530,5532,5533,5534,5535) -> (4772,4773,4775,4776)
Class
nt06537 TCR/BCR signaling
nt06220 Calcium signaling (cancer)
nt06160 Human T-cell leukemia virus 1 (HTLV-1)
nt06165 Epstein-Barr virus (EBV)
Type
Reference
Pathway
hsa04662  B cell receptor signaling pathway
Gene
102723407  IGH; immunoglobulin heavy variable 4-38-2-like
4067  LYN; LYN proto-oncogene, Src family tyrosine kinase
6850  SYK; spleen associated tyrosine kinase
695  BTK; Bruton tyrosine kinase
29760  BLNK; B cell linker
5336  PLCG2; phospholipase C gamma 2
801  CALM1; calmodulin 1
805  CALM2; calmodulin 2
808  CALM3; calmodulin 3
5530  PPP3CA; protein phosphatase 3 catalytic subunit alpha
5532  PPP3CB; protein phosphatase 3 catalytic subunit beta
5533  PPP3CC; protein phosphatase 3 catalytic subunit gamma
5534  PPP3R1; protein phosphatase 3 regulatory subunit B, alpha
5535  PPP3R2; protein phosphatase 3 regulatory subunit B, beta
4772  NFATC1; nuclear factor of activated T cells 1
4773  NFATC2; nuclear factor of activated T cells 2
4775  NFATC3; nuclear factor of activated T cells 3
4776  NFATC4; nuclear factor of activated T cells 4
Metabolite
C01245  D-myo-Inositol 1,4,5-trisphosphate
C00076  Calcium cation
Reference
PMID:27101923
  Authors
Moens L, Kane A, Tangye SG
  Title
Naive and memory B cells exhibit distinct biochemical responses following BCR engagement.
  Journal
Immunol Cell Biol 94:774-86 (2016)
DOI:10.1038/icb.2016.41
Reference
PMID:26227856
  Authors
Bojarczuk K, Bobrowicz M, Dwojak M, Miazek N, Zapala P, Bunes A, Siernicka M, Rozanska M, Winiarska M
  Title
B-cell receptor signaling in the pathogenesis of lymphoid malignancies.
  Journal
Blood Cells Mol Dis 55:255-65 (2015)
DOI:10.1016/j.bcmd.2015.06.016
Reference
PMID:23886342
  Authors
Puri KD, Di Paolo JA, Gold MR
  Title
B-cell receptor signaling inhibitors for treatment of autoimmune inflammatory diseases and B-cell malignancies.
  Journal
Int Rev Immunol 32:397-427 (2013)
DOI:10.3109/08830185.2013.818140
Reference
PMID:22000665
  Authors
Baba Y, Kurosaki T
  Title
Impact of Ca2+ signaling on B cell function.
  Journal
Trends Immunol 32:589-94 (2011)
DOI:10.1016/j.it.2011.09.004

  All links  
Pathway (1)   
   KEGG PATHWAY (1)   
Chemical substance (2)   
   KEGG COMPOUND (2)   
Gene (18)   
   KEGG GENES (18)   
Literature (4)   
   PubMed (4)   
All databases (25)   

Download RDF
DBGET integrated database retrieval system