Entry |
|
Name |
Escherichia EspJ/Tir to Actin signaling pathway
|
Definition |
EspJ -| (FYN,ABL) -> Tir -> NCK |
Expanded |
K23648 -| (2534,25) -> K12784 -> (4690,8440) |
Class |
nt06180 Pathogenic Escherichia coli
|
Type |
Pathogen
|
Pathway |
hsa05130 | Pathogenic Escherichia coli infection |
|
Disease |
H00277 | Enterohemorrhagic Escherichia coli (EHEC) infection |
H00278 | Enteropathogenic Escherichia coli (EPEC) infection |
|
Gene |
2534 | FYN; FYN proto-oncogene, Src family tyrosine kinase |
25 | ABL1; ABL proto-oncogene 1, non-receptor tyrosine kinase |
4690 | NCK1; NCK adaptor protein 1 |
8440 | NCK2; NCK adaptor protein 2 |
|
Perturbant |
K23648 (EspJ) | espJ; T3SS secreted effector ADP-ribosyltransferase EspJ |
K12784 (Tir) | tir; translocated intimin receptor |
|
Reference |
|
Authors |
Young JC, Clements A, Lang AE, Garnett JA, Munera D, Arbeloa A, Pearson J, Hartland EL, Matthews SJ, Mousnier A, Barry DJ, Way M, Schlosser A, Aktories K, Frankel G |
Title |
The Escherichia coli effector EspJ blocks Src kinase activity via amidation and ADP ribosylation. |
Journal |
|
Reference |
|
Authors |
Lai Y, Rosenshine I, Leong JM, Frankel G |
Title |
Intimate host attachment: enteropathogenic and enterohaemorrhagic Escherichia coli. |
Journal |
|