Entry |
|
Name |
LPA-GNA12/13-RhoA signaling pathway
|
Definition |
LPA -> LPAR -> GNA12/13 -> (ARHGEF12,ARHGEF1,ARHGEF11) -> RHOA -> ROCK1/2 |
Expanded |
C00681 -> (1902,9170,23566,2846,57121) -> (2768,10672) -> (23365,9138,9826) -> 387 -> (6093,9475) |
Class |
nt06180 Pathogenic Escherichia coli
|
Type |
Reference
|
Pathway |
hsa04810 | Regulation of actin cytoskeleton |
|
Gene |
1902 | LPAR1; lysophosphatidic acid receptor 1 |
9170 | LPAR2; lysophosphatidic acid receptor 2 |
23566 | LPAR3; lysophosphatidic acid receptor 3 |
2846 | LPAR4; lysophosphatidic acid receptor 4 |
57121 | LPAR5; lysophosphatidic acid receptor 5 |
2768 | GNA12; G protein subunit alpha 12 |
10672 | GNA13; G protein subunit alpha 13 |
23365 | ARHGEF12; Rho guanine nucleotide exchange factor 12 |
9138 | ARHGEF1; Rho guanine nucleotide exchange factor 1 |
9826 | ARHGEF11; Rho guanine nucleotide exchange factor 11 |
387 | RHOA; ras homolog family member A |
6093 | ROCK1; Rho associated coiled-coil containing protein kinase 1 |
9475 | ROCK2; Rho associated coiled-coil containing protein kinase 2 |
|
Metabolite |
C00681 | 1-Acyl-sn-glycerol 3-phosphate |
|
Reference |
|
Authors |
Kozasa T, Hajicek N, Chow CR, Suzuki N |
Title |
Signalling mechanisms of RhoGTPase regulation by the heterotrimeric G proteins G12 and G13. |
Journal |
|
Reference |
|
Authors |
O'Connor K, Chen M |
Title |
Dynamic functions of RhoA in tumor cell migration and invasion. |
Journal |
|
Reference |
|
Authors |
Riaz A, Huang Y, Johansson S |
Title |
G-Protein-Coupled Lysophosphatidic Acid Receptors and Their Regulation of AKT Signaling. |
Journal |
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