KEGG   REACTION: R00209
Entry
R00209                      Reaction                               

Name
pyruvate:NAD+ 2-oxidoreductase (CoA-acetylating);
pyruvate dehydrogenase complex
Definition
Pyruvate + CoA + NAD+ <=> Acetyl-CoA + CO2 + NADH + H+
Equation
Comment
multienzyme system
multi-step reaction (see R01699+R02569+R07618)
Reaction class
RC00001  C00003_C00004
RC00004  C00010_C00024
RC02742  C00022_C00024
Enzyme
Pathway
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
Module
M00307  Pyruvate oxidation, pyruvate => acetyl-CoA
Orthology
K00161  pyruvate dehydrogenase E1 component alpha subunit [EC:1.2.4.1]
K00162  pyruvate dehydrogenase E1 component beta subunit [EC:1.2.4.1]
K00163  pyruvate dehydrogenase E1 component [EC:1.2.4.1]
K00382  dihydrolipoamide dehydrogenase [EC:1.8.1.4]
K00627  pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase) [EC:2.3.1.12]
Other DBs
RHEA: 28045

KEGG   REACTION: R01196
Entry
R01196                      Reaction                               

Name
pyruvate:ferredoxin 2-oxidoreductase (CoA-acetylating)
Definition
2 Reduced ferredoxin + Acetyl-CoA + CO2 + 2 H+ <=> 2 Oxidized ferredoxin + Pyruvate + CoA
Equation
Reaction class
RC00004  C00010_C00024
RC02742  C00022_C00024
Enzyme
1.2.7.1         1.2.7.11
Pathway
rn00010  Glycolysis / Gluconeogenesis
rn00020  Citrate cycle (TCA cycle)
rn00620  Pyruvate metabolism
rn00650  Butanoate metabolism
rn00680  Methane metabolism
rn00720  Carbon fixation pathways in prokaryotes
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
Module
M00173  Reductive citrate cycle (Arnon-Buchanan cycle)
M00307  Pyruvate oxidation, pyruvate => acetyl-CoA
M00374  Dicarboxylate-hydroxybutyrate cycle
M00620  Incomplete reductive citrate cycle, acetyl-CoA => oxoglutarate
Orthology
K00169  pyruvate ferredoxin oxidoreductase alpha subunit [EC:1.2.7.1]
K00170  pyruvate ferredoxin oxidoreductase beta subunit [EC:1.2.7.1]
K00171  pyruvate ferredoxin oxidoreductase delta subunit [EC:1.2.7.1]
K00172  pyruvate ferredoxin oxidoreductase gamma subunit [EC:1.2.7.1]
K00174  2-oxoglutarate/2-oxoacid ferredoxin oxidoreductase subunit alpha [EC:1.2.7.3 1.2.7.11]
K00175  2-oxoglutarate/2-oxoacid ferredoxin oxidoreductase subunit beta [EC:1.2.7.3 1.2.7.11]
K00189  2-oxoisovalerate/pyruvate ferredoxin oxidoreductase gamma subunit [EC:1.2.7.7 1.2.7.1]
K03737  pyruvate-ferredoxin/flavodoxin oxidoreductase [EC:1.2.7.1 1.2.7.-]
Other DBs
RHEA: 44143

KEGG   REACTION: R10866
Entry
R10866                      Reaction                               

Name
pyruvate:flavodoxin 2-oxidoreductase (CoA-acetylating)
Definition
Pyruvate + CoA + Oxidized flavodoxin <=> Acetyl-CoA + CO2 + Reduced flavodoxin
Equation
Comment
nifJ
Reaction class
RC00004  C00010_C00024
RC02742  C00022_C00024
Enzyme
1.2.7.-
Pathway
rn00620  Pyruvate metabolism
rn00720  Carbon fixation pathways in prokaryotes
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
Module
M00173  Reductive citrate cycle (Arnon-Buchanan cycle)
Orthology
K03737  pyruvate-ferredoxin/flavodoxin oxidoreductase [EC:1.2.7.1 1.2.7.-]

KEGG   REACTION: R00212
Entry
R00212                      Reaction                               

Name
Acetyl-CoA:formate C-acetyltransferase
Definition
Acetyl-CoA + Formate <=> CoA + Pyruvate
Equation
Reaction class
RC00004  C00010_C00024
RC01181  C00022_C00058
RC02742  C00022_C00024
Enzyme
Pathway
rn00620  Pyruvate metabolism
rn00650  Butanoate metabolism
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
Orthology
K00656  formate C-acetyltransferase [EC:2.3.1.54]
Other DBs
RHEA: 11847

KEGG   RCLASS: RC02742
Entry
RC02742                     RClass                                 

Definition
C5a-C5a:C6a+*-*+S2a:C1a+O5a-C1a+O5a
Reactant pair
Related class
Reaction
Enzyme
1.2.1.104       1.2.3.6         1.2.7.1         1.2.7.11        
1.2.7.-         2.3.1.54
Pathway
rn00010  Glycolysis / Gluconeogenesis
rn00020  Citrate cycle (TCA cycle)
rn00620  Pyruvate metabolism
rn00650  Butanoate metabolism
rn00680  Methane metabolism
rn00720  Carbon fixation pathways in prokaryotes
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
RModule
RM903  Oxidative decarboxylation of 2-oxoacid to form its CoA derivative
Orthology
K00161  pyruvate dehydrogenase E1 component alpha subunit [EC:1.2.4.1]
K00162  pyruvate dehydrogenase E1 component beta subunit [EC:1.2.4.1]
K00163  pyruvate dehydrogenase E1 component [EC:1.2.4.1]
K00169  pyruvate ferredoxin oxidoreductase alpha subunit [EC:1.2.7.1]
K00170  pyruvate ferredoxin oxidoreductase beta subunit [EC:1.2.7.1]
K00171  pyruvate ferredoxin oxidoreductase delta subunit [EC:1.2.7.1]
K00172  pyruvate ferredoxin oxidoreductase gamma subunit [EC:1.2.7.1]
K00174  2-oxoglutarate/2-oxoacid ferredoxin oxidoreductase subunit alpha [EC:1.2.7.3 1.2.7.11]
K00175  2-oxoglutarate/2-oxoacid ferredoxin oxidoreductase subunit beta [EC:1.2.7.3 1.2.7.11]
K00189  2-oxoisovalerate/pyruvate ferredoxin oxidoreductase gamma subunit [EC:1.2.7.7 1.2.7.1]
K00382  dihydrolipoamide dehydrogenase [EC:1.8.1.4]
K00627  pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase) [EC:2.3.1.12]
K00656  formate C-acetyltransferase [EC:2.3.1.54]
K03737  pyruvate-ferredoxin/flavodoxin oxidoreductase [EC:1.2.7.1 1.2.7.-]

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