KEGG   REACTION: R00271
Entry
R00271                      Reaction                               

Name
acetyl-CoA:2-oxoglutarate C-acetyltransferase (thioester-hydrolysing, carboxymethyl forming)
Definition
Acetyl-CoA + H2O + 2-Oxoglutarate <=> (R)-2-Hydroxybutane-1,2,4-tricarboxylate + CoA
Equation
Reaction class
RC00004  C00010_C00024
RC00067  C00026_C01251
RC02754  C00024_C01251
Enzyme
Pathway
rn00300  Lysine biosynthesis
rn00620  Pyruvate metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01210  2-Oxocarboxylic acid metabolism
rn01230  Biosynthesis of amino acids
rn01240  Biosynthesis of cofactors
Module
M00030  Lysine biosynthesis, AAA pathway, 2-oxoglutarate => 2-aminoadipate => lysine
M00433  Lysine biosynthesis, 2-oxoglutarate => 2-oxoadipate
M00608  2-Oxocarboxylic acid chain extension, 2-oxoglutarate => 2-oxoadipate => 2-oxopimelate => 2-oxosuberate
Orthology
K01655  homocitrate synthase [EC:2.3.3.14]
K02594  homocitrate synthase NifV [EC:2.3.3.14]
K10977  methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-]
Other DBs
RHEA: 12932

KEGG   RCLASS: RC00067
Entry
RC00067                     RClass                                 

Definition
C1d-C5a:C1b-*:C1b+C6a+O1a-C1b+C6a+O5a
Reactant pair
Related class
Reaction
Enzyme
2.3.3.1         2.3.3.3         2.3.3.6         2.3.3.8         
2.3.3.14        2.3.3.16        2.3.3.17        2.3.3.18        
2.3.3.19        2.3.3.-         4.1.3.6         4.1.3.17        
4.1.3.34        4.1.3.-
Pathway
rn00020  Citrate cycle (TCA cycle)
rn00300  Lysine biosynthesis
rn00362  Benzoate degradation
rn00400  Phenylalanine, tyrosine and tryptophan biosynthesis
rn00440  Phosphonate and phosphinate metabolism
rn00630  Glyoxylate and dicarboxylate metabolism
rn00680  Methane metabolism
rn00720  Carbon fixation pathways in prokaryotes
rn00966  Glucosinolate biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
rn01210  2-Oxocarboxylic acid metabolism
rn01230  Biosynthesis of amino acids
rn01240  Biosynthesis of cofactors
RModule
RM001  2-Oxocarboxylic acid chain extension by tricarboxylic acid pathway
Orthology
K01643  citrate lyase subunit alpha / citrate CoA-transferase [EC:2.8.3.10]
K01644  citrate lyase subunit beta / citryl-CoA lyase [EC:4.1.3.34]
K01646  citrate lyase subunit gamma (acyl carrier protein)
K01647  citrate synthase [EC:2.3.3.1]
K01648  ATP citrate (pro-S)-lyase [EC:2.3.3.8]
K01655  homocitrate synthase [EC:2.3.3.14]
K02594  homocitrate synthase NifV [EC:2.3.3.14]
K05942  citrate (Re)-synthase [EC:2.3.3.3]
K10218  4-hydroxy-4-methyl-2-oxoglutarate aldolase [EC:4.1.3.17]
K10977  methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-]
K12910  2-phosphinomethylmalate synthase [EC:2.3.3.18]
K15230  ATP-citrate lyase alpha-subunit [EC:2.3.3.8]
K15231  ATP-citrate lyase beta-subunit [EC:2.3.3.8]
K15234  citryl-CoA lyase [EC:4.1.3.34]
K15741  methylthioalkylmalate synthase 1 [EC:2.3.3.17]
K15742  methylthioalkylmalate synthase 3 [EC:2.3.3.17]
K17748  benzylmalate synthase [EC:2.3.3.-]
K21934  2-phosphonomethylmalate synthase [EC:2.3.3.19]

KEGG   RCLASS: RC02754
Entry
RC02754                     RClass                                 

Definition
C1a-C1b:*-C1d:C5a-C6a
C5a-C6a:S2a+*-*+O6a:C1a+O5a-C1b+O6a
Reactant pair
Related class
Reaction
Enzyme
2.3.3.6         2.3.3.13        2.3.3.14        4.1.3.-
Pathway
rn00300  Lysine biosynthesis
rn00620  Pyruvate metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
Orthology
K01649  2-isopropylmalate synthase [EC:2.3.3.13]
K01655  homocitrate synthase [EC:2.3.3.14]
K02594  homocitrate synthase NifV [EC:2.3.3.14]
K10977  methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-]

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