KEGG   REACTION: R01213
Entry
R01213                      Reaction                               

Name
acetyl-CoA:3-methyl-2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming);
3-Carboxy-3-hydroxy-4-methylpentanoate 3-methyl-2-oxobutanoate-lyase (CoA-acetylating)
Definition
alpha-Isopropylmalate + CoA <=> Acetyl-CoA + 3-Methyl-2-oxobutanoic acid + H2O
Equation
Reaction class
RC00004  C00010_C00024
RC00470  C00141_C02504
RC02754  C00024_C02504
Enzyme
Pathway
rn00290  Valine, leucine and isoleucine biosynthesis
rn00620  Pyruvate metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01210  2-Oxocarboxylic acid metabolism
rn01230  Biosynthesis of amino acids
Module
M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate
Orthology
K01649  2-isopropylmalate synthase [EC:2.3.3.13]
Other DBs
RHEA: 21527

KEGG   RCLASS: RC02754
Entry
RC02754                     RClass                                 

Definition
C1a-C1b:*-C1d:C5a-C6a
C5a-C6a:S2a+*-*+O6a:C1a+O5a-C1b+O6a
Reactant pair
Related class
Reaction
Enzyme
2.3.3.6         2.3.3.13        2.3.3.14        4.1.3.-
Pathway
rn00300  Lysine biosynthesis
rn00620  Pyruvate metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
Orthology
K01649  2-isopropylmalate synthase [EC:2.3.3.13]
K01655  homocitrate synthase [EC:2.3.3.14]
K02594  homocitrate synthase NifV [EC:2.3.3.14]
K10977  methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-]

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