| Entry |
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| Name |
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate:NAD+ oxidoreductase (decarboxylating);
homoisocitrate:NAD+ oxidoreductase (decarboxylating)
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| Definition |
Homoisocitrate + NAD+ <=> 2-Oxoadipate + CO2 + NADH + H+
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| Equation |
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| Comment |
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| Reaction class |
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| Enzyme |
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| Pathway |
| rn01110 | Biosynthesis of secondary metabolites |
| rn01120 | Microbial metabolism in diverse environments |
| rn01210 | 2-Oxocarboxylic acid metabolism |
| rn01230 | Biosynthesis of amino acids |
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| Module |
| M00030 | Lysine biosynthesis, AAA pathway, 2-oxoglutarate => 2-aminoadipate => lysine |
| M00433 | Lysine biosynthesis, 2-oxoglutarate => 2-oxoadipate |
| M00608 | 2-Oxocarboxylic acid chain extension, 2-oxoglutarate => 2-oxoadipate => 2-oxopimelate => 2-oxosuberate |
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| Orthology |
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| Reference |
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| Authors |
Rowley B, Tucci AF |
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| Title |
Homoisocitric dehydrogenase from yeast. |
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| Journal |
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| Reference |
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| Authors |
Chilina K, Thomas U, Tucci AF, McMichael KD, Stevens CM. |
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| Title |
Synthesis and absolute configuration of the isomers of homoisocitric acid (1-hydroxy-1,2,4-butanetricarboxylic acid) and the stereochemistry of lysine biosynthesis. |
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| Journal |
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| Other DBs |
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