KEGG   REACTION: R03270
Entry
R03270                      Reaction                               

Definition
2-(alpha-Hydroxyethyl)thiamine diphosphate + Enzyme N6-(lipoyl)lysine <=> [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + Thiamin diphosphate
Equation
Comment
2-oxoglutarate dehydrogenase complex: pyruvate dehydrogenase (see R01699)
second step of two-step reaction (R01699 or R00014+R03270)
following after R00014
Reaction class
RC00027  C00068_C05125
RC00627  C15972_C16255
RC02882  C05125_C16255
Enzyme
Pathway
rn00010  Glycolysis / Gluconeogenesis
rn00020  Citrate cycle (TCA cycle)
rn00620  Pyruvate metabolism
Module
M00307  Pyruvate oxidation, pyruvate => acetyl-CoA
Orthology
K00161  pyruvate dehydrogenase E1 component alpha subunit [EC:1.2.4.1]
K00162  pyruvate dehydrogenase E1 component beta subunit [EC:1.2.4.1]
K00163  pyruvate dehydrogenase E1 component [EC:1.2.4.1]

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Ontology (1)   
   KEGG BRITE (1)   
Pathway (7)   
   KEGG PATHWAY (6)   
   KEGG MODULE (1)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG RCLASS (3)   
Gene (13591)   
   KEGG ORTHOLOGY (3)   
   KEGG GENES (13588)   
All databases (13607)   

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KEGG   RCLASS: RC00027
Entry
RC00027                     RClass                                 

Definition
C8x-C8y:*-C1c:N5y+S2x-N5y+S2x
Reactant pair
Related class
Reaction
Enzyme
1.2.4.1         1.2.4.2         1.2.4.4         2.2.1.1         
2.2.1.3         2.2.1.6         4.1.1.1
Pathway
rn00010  Glycolysis / Gluconeogenesis
rn00020  Citrate cycle (TCA cycle)
rn00280  Valine, leucine and isoleucine degradation
rn00620  Pyruvate metabolism
rn00640  Propanoate metabolism
Orthology
K00161  pyruvate dehydrogenase E1 component alpha subunit [EC:1.2.4.1]
K00162  pyruvate dehydrogenase E1 component beta subunit [EC:1.2.4.1]
K00163  pyruvate dehydrogenase E1 component [EC:1.2.4.1]
K00164  2-oxoglutarate dehydrogenase E1 component [EC:1.2.4.2]
K00166  2-oxoisovalerate dehydrogenase E1 component alpha subunit [EC:1.2.4.4]
K00167  2-oxoisovalerate dehydrogenase E1 component beta subunit [EC:1.2.4.4]
K01568  pyruvate decarboxylase [EC:4.1.1.1]
K01652  acetolactate synthase I/II/III large subunit [EC:2.2.1.6]
K01653  acetolactate synthase I/III small subunit [EC:2.2.1.6]
K11258  acetolactate synthase II small subunit [EC:2.2.1.6]
K11381  2-oxoisovalerate dehydrogenase E1 component [EC:1.2.4.4]

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Ontology (1)   
   KEGG BRITE (1)   
Pathway (5)   
   KEGG PATHWAY (5)   
Chemical reaction (26)   
   KEGG ENZYME (7)   
   KEGG REACTION (19)   
Gene (11)   
   KEGG ORTHOLOGY (11)   
All databases (43)   

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KEGG   RCLASS: RC02882
Entry
RC02882                     RClass                                 

Definition
C1c-C5a:C8y+*-*+S2a:C1a+O1a-C1a+O5a
Reactant pair
Related class
Reaction
Enzyme
Pathway
rn00010  Glycolysis / Gluconeogenesis
rn00020  Citrate cycle (TCA cycle)
rn00620  Pyruvate metabolism
Orthology
K00161  pyruvate dehydrogenase E1 component alpha subunit [EC:1.2.4.1]
K00162  pyruvate dehydrogenase E1 component beta subunit [EC:1.2.4.1]
K00163  pyruvate dehydrogenase E1 component [EC:1.2.4.1]

  All links  
Ontology (1)   
   KEGG BRITE (1)   
Pathway (3)   
   KEGG PATHWAY (3)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Gene (3)   
   KEGG ORTHOLOGY (3)   
All databases (9)   

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KEGG   RCLASS: RC00627
Entry
RC00627                     RClass                                 

Definition
S1a-S3x:*-S3x:C1c-C1y
S2a-S3x:C5a+*-*+S3x:C1b-C1x
Reactant pair
Related class
Reaction
Enzyme
1.2.4.1         1.2.4.2         1.2.4.4
Pathway
rn00010  Glycolysis / Gluconeogenesis
rn00020  Citrate cycle (TCA cycle)
rn00280  Valine, leucine and isoleucine degradation
rn00620  Pyruvate metabolism
rn00640  Propanoate metabolism
Orthology
K00161  pyruvate dehydrogenase E1 component alpha subunit [EC:1.2.4.1]
K00162  pyruvate dehydrogenase E1 component beta subunit [EC:1.2.4.1]
K00163  pyruvate dehydrogenase E1 component [EC:1.2.4.1]
K00164  2-oxoglutarate dehydrogenase E1 component [EC:1.2.4.2]
K00166  2-oxoisovalerate dehydrogenase E1 component alpha subunit [EC:1.2.4.4]
K00167  2-oxoisovalerate dehydrogenase E1 component beta subunit [EC:1.2.4.4]
K11381  2-oxoisovalerate dehydrogenase E1 component [EC:1.2.4.4]
K15791  probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 [EC:1.2.4.2]

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Ontology (1)   
   KEGG BRITE (1)   
Pathway (5)   
   KEGG PATHWAY (5)   
Chemical reaction (15)   
   KEGG ENZYME (3)   
   KEGG REACTION (12)   
Gene (8)   
   KEGG ORTHOLOGY (8)   
All databases (29)   

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