KEGG   REACTION: R04825
Entry
R04825                      Reaction                               
Name
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestane:NADP+ oxidoreductase (B-specific)
Definition
3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane + NADP+ <=> 7alpha,12alpha-Dihydroxy-5beta-cholestan-3-one + NADPH + H+
Equation
C05454 + C00006 <=> C05453 + C00005 + C00080
Reaction class
RC00001  C00005_C00006
RC00144  C05453_C05454
Enzyme
1.1.1.50
Pathway
rn00120  Primary bile acid biosynthesis
rn01100  Metabolic pathways
Module
M00104  Bile acid biosynthesis, cholesterol => cholate/chenodeoxycholate
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.50
     R04825  3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane + NADP+ <=> 7alpha,12alpha-Dihydroxy-5beta-cholestan-3-one + NADPH + H+
IUBMB reaction hierarchy [BR:br08202]
 1. Oxidoreductase reactions
  1.1.1.50
   R10423  3alpha-Hydroxysteroid <=> 3-Oxosteroid
    R04825  3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane <=> 7alpha,12alpha-Dihydroxy-5beta-cholestan-3-one
Orthology
K00037  3alpha-hydroxysteroid 3-dehydrogenase / chlordecone reductase [EC:1.1.1.50 1.1.1.357 1.1.1.225]

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (5)   
   KEGG PATHWAY (4)   
   KEGG MODULE (1)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG RCLASS (2)   
   SABIO-RK (1)   
Gene (45)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (44)   
All databases (61)   

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