KEGG   REACTION: R05463
Entry
R05463                      Reaction                               

Name
6-methylpretetramide,NADPH:oxygen oxidoreductase (4-hydroxylating)
Definition
6-Methylpretetramide + NADPH + Oxygen + H+ <=> 4-Hydroxy-6-methylpretetramide + NADP+ + H2O
Equation
Comment
subsequently R05462
Reaction class
RC00001  C00005_C00006
RC00236  C06628_C06629
Enzyme
Pathway
rn00253  Tetracycline biosynthesis
rn01057  Biosynthesis of type II polyketide products
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00780  Tetracycline/oxytetracycline biosynthesis, pretetramide => tetracycline/oxytetracycline
M00823  Chlortetracycline biosynthesis, pretetramide => chlortetracycline
Orthology
K14253  6-methylpretetramide 4-monooxygenase [EC:1.14.13.232]
Other DBs
RHEA: 50011

KEGG   RCLASS: RC00236
Entry
RC00236                     RClass                                 

Definition
C8x-C8y:*-O1a:C8y+C8y-C8y+C8y
Reactant pair
Related class
Reaction
Enzyme
1.14.11.60      1.14.13.6       1.14.13.7       1.14.13.19      
1.14.13.50      1.14.13.127     1.14.13.180     1.14.13.182     
1.14.13.232     1.14.14.12      1.14.14.60      1.14.14.164     
1.14.14.166     1.14.99.23      1.14.99.60      1.14.-.-        
1.97.1.2
Pathway
rn00253  Tetracycline biosynthesis
rn00360  Phenylalanine metabolism
rn00362  Benzoate degradation
rn00405  Phenazine biosynthesis
rn00623  Toluene degradation
rn00626  Naphthalene degradation
rn00904  Diterpenoid biosynthesis
rn00950  Isoquinoline alkaloid biosynthesis
rn00980  Metabolism of xenobiotics by cytochrome P450
rn00984  Steroid degradation
rn01057  Biosynthesis of type II polyketide products
rn01059  Biosynthesis of enediyne antibiotics
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01220  Degradation of aromatic compounds
RModule
RM006  Dihydroxylation of aromatic ring, type 2 (two monooxygenase reactions)
Orthology
K03380  phenol 2-monooxygenase (NADPH) [EC:1.14.13.7]
K05712  3-(3-hydroxy-phenyl)propionate hydroxylase [EC:1.14.13.127]
K14253  6-methylpretetramide 4-monooxygenase [EC:1.14.13.232]
K14586  2-naphthoate monooxygenase
K15950  aklavinone 12-hydroxylase [EC:1.14.13.180]
K16047  3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase [EC:1.14.14.12]
K16048  3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase reductase component [EC:1.5.1.-]
K17940  2-heptyl-3-hydroxy-4(1H)-quinolone synthase [EC:1.14.13.182]
K20621  (S)-N-methylcanadine 1-hydroxylase [EC:1.14.14.166]
K21222  cytochrome P450 monooxygenase [EC:1.14.-.-]
K21257  orsellenic acid P450 oxidase [EC:1.14.-.-]
K22635  ferruginol monooxygenase / sugiol synthase [EC:1.14.14.60 1.14.14.65]
K22636  ferruginol synthase / ferruginol monooxygenase [EC:1.14.13.190 1.14.14.60]

DBGET integrated database retrieval system