KEGG   REACTION: R05469
Entry
R05469                      Reaction                               

Name
dihydroclavaminate,2-oxoglutarate:oxygen oxidoreductase (desaturating)
Definition
Dihydroclavaminic acid + Oxygen + 2-Oxoglutarate <=> Clavaminic acid + Succinate + CO2 + H2O
Equation
Comment
Reaction class
RC01391  C06659_C06660
Enzyme
Pathway
rn00331  Clavulanic acid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00674  Clavaminate biosynthesis, arginine + glyceraldehyde-3P => clavaminate
Orthology
K12675  clavaminate synthase [EC:1.14.11.21]
Reference
1  [PMID:9614345]
  Authors
McGowan SJ, Bycroft BW, Salmond GP.
  Title
Bacterial production of carbapenems and clavams: evolution of beta-lactam antibiotic pathways.
  Journal
Trends Microbiol 6:203-8 (1998)
DOI:10.1016/S0966-842X(98)01251-7

KEGG   RCLASS: RC01391
Entry
RC01391                     RClass                                 

Definition
C1b-C2b:*-*:C1b+C1y-C1b+C2y
C1y-C2y:*-*:C1b+C1y+O2x-C2b+C1y+O2x
Reactant pair
Related class
Reaction
Enzyme
Pathway
rn00331  Clavulanic acid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K12675  clavaminate synthase [EC:1.14.11.21]

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