KEGG   REACTION: R06453
Entry
R06453                      Reaction                               
Definition
Malonyl-CoA + 6 Methylmalonyl-CoA + 6 NADPH + 6 H+ <=> 8,8a-Deoxyoleandolide + 7 CoA + 7 CO2 + H2O + 6 NADP+
Equation
C00083 + 6 C02557 + 6 C00005 + 6 C00080 <=> C11989 + 7 C00010 + 7 C00011 + C00001 + 6 C00006
Comment
8,8a-deoxyoleandolide synthase,OleA1-3
Reaction class
RC00001  C00005_C00006
RC00004  C00010_C00083  C00010_C02557
RC02826  C02557_C11989
RC02828  C02557_C11989
RC02829  C02557_C11989
RC02830  C02557_C11989
RC02831  C02557_C11989
RC02918  C00083_C11989
Pathway
rn00522  Biosynthesis of 12-, 14- and 16-membered macrolides
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00775  Oleandomycin biosynthesis, malonyl-CoA + methylmalonyl-CoA => 8,8a-deoxyoleandolide => oleandomycin
Orthology
K16007  8,8a-deoxyoleandolide synthase 1
K24565  8,8a-deoxyoleandolide synthase 2
K24566  8,8a-deoxyoleandolide synthase 3

  All links  
Pathway (7)   
   KEGG PATHWAY (6)   
   KEGG MODULE (1)   
Chemical substance (9)   
   KEGG COMPOUND (9)   
Chemical reaction (8)   
   KEGG RCLASS (8)   
Gene (9)   
   KEGG ORTHOLOGY (3)   
   KEGG GENES (6)   
All databases (33)   

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