KEGG   REACTION: R06453
Entry
R06453                      Reaction                               

Definition
Malonyl-CoA + 6 Methylmalonyl-CoA + 6 NADPH + 6 H+ <=> 8,8a-Deoxyoleandolide + 7 CoA + 7 CO2 + H2O + 6 NADP+
Equation
C00083 + 6 C02557 + 6 C00005 + 6 C00080 <=> C11989 + 7 C00010 + 7 C00011 + C00001 + 6 C00006
Comment
8,8a-deoxyoleandolide synthase,OleA1-3
Reaction class
RC00001  C00005_C00006
RC00004  C00010_C00083  C00010_C02557
RC02826  C02557_C11989
RC02828  C02557_C11989
RC02829  C02557_C11989
RC02830  C02557_C11989
RC02831  C02557_C11989
RC02918  C00083_C11989
Pathway
rn00522  Biosynthesis of 12-, 14- and 16-membered macrolides
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00775  Oleandomycin biosynthesis, malonyl-CoA + methylmalonyl-CoA => 8,8a-deoxyoleandolide => oleandomycin
Orthology
K16007  8,8a-deoxyoleandolide synthase 1
K24565  8,8a-deoxyoleandolide synthase 2
K24566  8,8a-deoxyoleandolide synthase 3

KEGG   RCLASS: RC02831
Entry
RC02831                     RClass                                 

Definition
C1c-C1y:C6a+*-*+C1y:C1a+C5a-C1a+C7x
C5a-C7x:S2a+*-*+O7x:C1c+O5a-C1y+O6a
Reactant pair
Related class
Reaction
Enzyme
2.3.1.94        2.3.1.239
Pathway
rn00522  Biosynthesis of 12-, 14- and 16-membered macrolides
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K10817  6-deoxyerythronolide-B synthase EryAI [EC:2.3.1.94]
K16000  narbonolide/10-deoxymethynolide synthase [EC:2.3.1.240 2.3.1.239]
K16001  narbonolide/10-deoxymethynolide synthase [EC:2.3.1.240 2.3.1.239]
K16002  narbonolide/10-deoxymethynolide synthase [EC:2.3.1.240 2.3.1.239]
K16007  8,8a-deoxyoleandolide synthase 1
K24563  6-deoxyerythronolide B synthase EryAII [EC:2.3.1.94]
K24564  6-deoxyerythronolide B synthase EryAIII [EC:2.3.1.94]
K24565  8,8a-deoxyoleandolide synthase 2
K24566  8,8a-deoxyoleandolide synthase 3

KEGG   RCLASS: RC02826
Entry
RC02826                     RClass                                 

Definition
C1c-C1y:C6a+*-*+C1y:C1a+C5a-C1a+C1y
C5a-C1y:S2a+*-*+C1y:C1c+O5a-C1y+O1a
Reactant pair
Related class
Reaction
Enzyme
Pathway
rn00522  Biosynthesis of 12-, 14- and 16-membered macrolides
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K10817  6-deoxyerythronolide-B synthase EryAI [EC:2.3.1.94]
K16007  8,8a-deoxyoleandolide synthase 1
K24563  6-deoxyerythronolide B synthase EryAII [EC:2.3.1.94]
K24564  6-deoxyerythronolide B synthase EryAIII [EC:2.3.1.94]
K24565  8,8a-deoxyoleandolide synthase 2
K24566  8,8a-deoxyoleandolide synthase 3

KEGG   RCLASS: RC02918
Entry
RC02918                     RClass                                 

Definition
C1a-C1b:*-C6a:C1y-C5a
C1y-C5a:C1y+*-*+S2a:C1a+O7x-C1b+O5a
O7x-O5a:C7x-*:C1y-C5a
Reactant pair
Related class
Reaction
Pathway
rn00522  Biosynthesis of 12-, 14- and 16-membered macrolides
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K16007  8,8a-deoxyoleandolide synthase 1
K24565  8,8a-deoxyoleandolide synthase 2
K24566  8,8a-deoxyoleandolide synthase 3

KEGG   RCLASS: RC02828
Entry
RC02828                     RClass                                 

Definition
C1c-C1y:C6a+*-*+C1y:C1a+C5a-C1a+C5x
C5a-C5x:S2a+*-*+C1y:C1c+O5a-C1y+O5x
Reactant pair
Related class
Reaction
Enzyme
2.3.1.94        2.3.1.240
Pathway
rn00522  Biosynthesis of 12-, 14- and 16-membered macrolides
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K10817  6-deoxyerythronolide-B synthase EryAI [EC:2.3.1.94]
K16000  narbonolide/10-deoxymethynolide synthase [EC:2.3.1.240 2.3.1.239]
K16001  narbonolide/10-deoxymethynolide synthase [EC:2.3.1.240 2.3.1.239]
K16002  narbonolide/10-deoxymethynolide synthase [EC:2.3.1.240 2.3.1.239]
K16003  narbonolide synthase [EC:2.3.1.240]
K16007  8,8a-deoxyoleandolide synthase 1
K24563  6-deoxyerythronolide B synthase EryAII [EC:2.3.1.94]
K24564  6-deoxyerythronolide B synthase EryAIII [EC:2.3.1.94]
K24565  8,8a-deoxyoleandolide synthase 2
K24566  8,8a-deoxyoleandolide synthase 3

KEGG   RCLASS: RC02829
Entry
RC02829                     RClass                                 

Definition
C1c-C1y:C6a+*-*+C5x:C1a+C5a-C1a+C1x
C5a-C1x:O5a+S2a+*-*+*+C1y:C1c-C1y
Reactant pair
Related class
Reaction
Enzyme
2.3.1.94        2.3.1.239       2.3.1.240
Pathway
rn00522  Biosynthesis of 12-, 14- and 16-membered macrolides
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K10817  6-deoxyerythronolide-B synthase EryAI [EC:2.3.1.94]
K15988  tylactone synthase 1
K16000  narbonolide/10-deoxymethynolide synthase [EC:2.3.1.240 2.3.1.239]
K16001  narbonolide/10-deoxymethynolide synthase [EC:2.3.1.240 2.3.1.239]
K16002  narbonolide/10-deoxymethynolide synthase [EC:2.3.1.240 2.3.1.239]
K16003  narbonolide synthase [EC:2.3.1.240]
K16007  8,8a-deoxyoleandolide synthase 1
K24555  tylactone synthase 2
K24556  tylactone synthase 3
K24557  tylactone synthase 4
K24558  tylactone synthase 5
K24563  6-deoxyerythronolide B synthase EryAII [EC:2.3.1.94]
K24564  6-deoxyerythronolide B synthase EryAIII [EC:2.3.1.94]
K24565  8,8a-deoxyoleandolide synthase 2
K24566  8,8a-deoxyoleandolide synthase 3

KEGG   RCLASS: RC02830
Entry
RC02830                     RClass                                 

Definition
C1c-C1y:C6a+*-*+C1x:C1a+C5a-C1a+C1y
C5a-C1y:S2a+*-*+C1y:C1c+O5a-C1y+O1a
Reactant pair
Related class
Reaction
Enzyme
2.3.1.94        2.3.1.239       2.3.1.240
Pathway
rn00522  Biosynthesis of 12-, 14- and 16-membered macrolides
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K10817  6-deoxyerythronolide-B synthase EryAI [EC:2.3.1.94]
K16000  narbonolide/10-deoxymethynolide synthase [EC:2.3.1.240 2.3.1.239]
K16001  narbonolide/10-deoxymethynolide synthase [EC:2.3.1.240 2.3.1.239]
K16002  narbonolide/10-deoxymethynolide synthase [EC:2.3.1.240 2.3.1.239]
K16003  narbonolide synthase [EC:2.3.1.240]
K16007  8,8a-deoxyoleandolide synthase 1
K24563  6-deoxyerythronolide B synthase EryAII [EC:2.3.1.94]
K24564  6-deoxyerythronolide B synthase EryAIII [EC:2.3.1.94]
K24565  8,8a-deoxyoleandolide synthase 2
K24566  8,8a-deoxyoleandolide synthase 3

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